Biomedical subjects
Publications and source records attributed to G Schwesinger.
Report on a 83-year-old woman with perforation of the ventricular septum by an electrode catheter as complication of a transvenous endocardial stimulation. Discussion of the various complications as well as of the diagnostics and therapy.
Report on a 69-year-old male with spontaneous atraumatic rupture of the oesophagus (Boerhaave's syndrome) in clinically mentioned chronic abuse of alcohol and massive vomiting which preceded the event. Discussion of causes, differential diagnosis, therapy as well as of forensic aspects of this syndrome.
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Case report about a carcinoma of the appendix, recognized by obduction of an 58-years old man. Discussion of rarity, difficult clinical diagnostic, histological classification, metastasis and problems of differential diagnosis and therapy.
Report on a massive gastric haemorrhage from an exulceratio simplex Dieulafoy in a 54-year-old male. Discussion of the possible causes, differential diagnosis and prognosis of the haemorrhage.
Melorheostosis was diagnosed in a 13 year old female. Two years later an x-ray of the skull showed an calcified intracerebral mass. At the age of 18 years the patient died. The autopsy confirmed the diagnosis of melorheostosis and revealed a meningioma of falx cerebri in close proximity to predominantly intraventricular calcified tissue. A neurinoma of the left acoustic nerve was also found. In the literature melorheostosis has been anecdotally described in combination with nevi, hemangiomas, pelvic lipoma, lipoma of the spinal cord, chondrofibromas of the median nerve, tuberous sclerosis and neurofibromatosis. The nature of the relationship between melorheostosis and neoplasms has not been clarified. Those observations as well as the present report indicate an increased frequency of tumors (particularly of the nervous system) in patients with melorheostosis.
Intrathecal methotrexate-overdosage in the meningosis therapy leads to CNS damages dependent on dose. It was given a own case report and a literature review with clinical symptoms and the therapy in this complication. Neuropathologic findings included demyelinisation und necrosis of the white matter.
Report on a 45-year-old man with massive haematogenic metastasation of a bronchial carcinoma into the penis. Reference to the rarity of the findings, ways of metastasation, tumorous spectre of the metastases, differential diagnosis and clinical symptoms.
On the basis of a generalized primary amyloidosis with massive affection of the gastro-intestinal tract in a 58-year-old male form and localization, methods of pathologo-morphological proof, complications of the gastrointestinal tract as well as therapy of the disease are discussed.
Report on a 40-year-old male with manifest alcoholic cardiomyopathy during massive chronic misuse of alcohol lasting many years. Discussion of the morphologic findings, clinical symptoms as well as of the results of animal-experimental studies concerning this clinical picture.
Report on an extremely thin-walled, not ruptured spurious aneurysm (pseudoaneurysm) in the apical region of the left ventricle in a 82-year-old woman. Discussion of the causal and formal pathogenesis of the disinvagination with reference to complications, diagnostics and therapy.
By means of a special procedure of preparing and colouring blood smears of adult male Wistar rats the plasma protein film (PPF) on erythrocytes was investigated before and after injecting 3 mg of 20-methylcholanthren per animal. It was as early as on the 14th day post injection that a significant alteration of PPF towards initial and control values could be found. Causes and possible consequences are discussed.
Immunohistochemical and histological investigations were undertaken on 24 surgically-removed pituitary adenomas. By histology (haemalu-eosin staining), 7 chromophobe, 12 acidophil and 5 basophil pituitary adenomas were revealed. For immunohistochemical purposes the peroxidase-antiperoxidase technique was applied. Primary antisera against 10 hormones were used. By immunohistochemistry, 7 prolactin-containing, 2 TSH-containing, 2 GH-containing and 1 beta-endorphin-containing pituitary adenomas were identified. Furthermore, 1 mixed thyrotropic-prolactin human pituitary adenoma was detected. A possible connection between histological and immunocytochemical findings is discussed.
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Report on a splenic cyst in a 48-year-old female. On the basis of the post-mortem findings as well as of the survey of literature discussion of etiology, differential diagnosis and diagnostics. It is referred to the significance of the OSPI syndrome as possible sequela of splenectomy.
Report on a paraganglioma of the left division place of the carotid and the common occurrence with adenomas in other endocrine organs (hypophysis, thyroid gland, adrenal gland and pancrease) in the sense of an MEA-syndrome (multiple endocrine adenopathy) in a 75-year-old woman. Discussion of the morphologic findings as well as reference to the multiple occurrence of adenopathies from the APUD cell system.
Report on 9 primary tumours of the heart as well as of pericardium (3 sarcomas, 3 myxomas, 1 rhabdomyoma as well as 1 mesothelioma and 1 lipoma). Discussion of histology, complications, diagnostics and therapy of these neoplasias on the basis of own material as well as of literature.