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Biomedical subjects

G Schaeg

Publications and source records attributed to G Schaeg.

At least 19 recordsLinked to original sources
PubMed1991

[Primary cutaneous leiomyosarcoma].

Primary leiomyosarcomas of the superficial soft tissues are very rare neoplasms. Because of the different biological behaviour, they should be divided into cutaneous and subcutaneous tumours. Differential diagnosis includes leiomyomas, skin metastases from extracutaneous leiomyosarcomas, and other spindle-cell tumours of the skin. Ultrastructural and immunohistochemical investigations are useful when light microscopic features do not allow an unequivocal diagnosis. Although local recurrences develop in almost half the patients with cutaneous leiomyosarcomas, the prognosis is predominantly good. In contrast, metastatic spread is more common in patients with subcutaneous leiomyosarcomas. Treatment for superficial leiomyosarcomas consists in wide excision. We report on a 76-year-old women with a local recurrence of a primary cutaneous leiomyosarcoma.

Aged↗
PubMed1990

[Electron microscopy studies of the collagen fiber structure of the human tympanic membrane in an adhesive process].

In an EM study, the collagen fiber arrangement of the lamina propria in adhesive otitis media was investigated. Nine biopsies of the tympanic membrane were taken intraoperatively, and compared with two normal ones. The physiological specimens showed a regular arrangement of collagen fibrils and fibers, the typical network of the lamina propria. This confirmed results reported previously. In all adhesive otitis media samples the regular structure of the fiber arrangement was disturbed. Degenerative processes were to be found in the form of hyaline changes, with the network character of the fibers no longer in evidence. In one specimen a mass of microfibrils was observed, which was possibly a sign of reparative processes. The pathohistological findings in adhesive otitis media may be due to mechanical stresses (tubal function). Aside from that, they may also be caused by the biochemical influence of specific collagenases, which have been found by several authors in secretory otitis was well as in cholesteatoma.

Biopsy↗
PubMed1989

[Primary neuroendocrine Merkel cell carcinoma of the skin].

A 78-year-old woman noticed a nodule on the dorsal aspect of the left lower leg which caused no symptoms but gradually increased in size. The raised, brown-red nodule, about 1.5 cm in diameter, was widely excised because malignancy was suspected. Light and electronmicroscopy revealed changes typical of Merkel-cell carcinoma. Immunohistochemistry demonstrated neuron-specific enolase and cytokeratin. No metastases were found. Together with Langerhans cells and melanocytes, Merkel cells belong to the three non-keratinocyte cell types of the epidermis.

Aged↗
PubMed1989

[Functional morphology of pulp tissue].

As compared with mesenchyme no genuine defense cells are developed in the tissue of the dental pulp and the nervous tissue. This is a further hint for the common development from ectoderm. The three dimensional meshwork of pulpa fibroblasts ("mesectoderm") is structured by elongated cell processes connected with each other by a variety of special cell junctions ("electronic cell coupling"). Metabolites from the microcirculation and neuropeptides from vegetative axons influence the activity of fibroblasts synthetizing groundsubstance. The meshwork of the groundsubstance has exclusion effects concerning molecules with a distinct molecular weight and charge. Thus a primitive defense system is established. With this the role of a newly described cell type of the dental pulp, the "lymphocytic pericyte" is discussed. Because of the poor capacity of the pulpa tissue for immunological reactions pathologically disorders may easily become chronically spreading their antigenic components throughout the body.

Adult↗
PubMed1987

[Cowpox virus infection in a young girl].

An genuine cowpox virus was isolated in a 6-year-old girl with a circumscribed skin lesion between the thumb and forefinger. In the beginning, the lesion was a proliferating skin change, which later became ulcerative with central hemorrhagic necrosis (umbilicated pock). Electron microscopy as well as histological, biological (cell and host range) and serological methods were used to characterize the virus. Cats and rodents are discussed as potential virus carriers. Voluntary vaccination against orthopox should be provided for persons at risk of infection.

Child↗
PubMed1986

[Jadassohn type anetoderma--case report].

A 19-year-old patient suffering from Jadassohn's anetoderma with progressive dermatrophia showed positive reaction to treatment with chloroquin diphosphate.

Actin Cytoskeleton↗
PubMed1986

[Oral hairy leukoplakia--early symptom of HTLV-III/LAV infection].

Epstein-Barr virus was demonstrated electronmicroscopically in a leucoplakic area of the tongue of a man infected with HTLV-III/LAV. Oral "hairy" leucoplakia, diagnosed from the clinical findings, histology and by electronmicroscopy, in this patients is to be interpreted as the initial sign of an HTLV-III/LAV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1986

[Dowling-Meara Epidermolysis bullosa herpetiformis].

A new born girl perinatally suffered from a generalized blistering disease of the skin. By means of histological, in particular ultrastructural methods the diagnosis of Epidermolysis bullosa herpetiformis Dowling Meara could be confirmed in the first weeks of life. The Dowling Meara type is one of the epidermal variants of this group of inherited blistering diseases with a relative benign course. The early diagnosis is helpful in the prognostic assessment of the disease and in the medical and genetic advice for the parents.

Basement Membrane↗
PubMed1985

[Heck's disease].

The clinical, microbiological, histological and electron microscopical findings in cases of oral papillomatosis (Heck's disease, focal epithelial hyperplasia), as well as differential diagnosis and therapy are presented. Electron microscopic investigations confirmed the presence of human papilloma virus (HPV) in the lesions of Heck's disease.

Child↗
PubMed1984

[Groenblad-Strandberg syndrome].

On the basis of medical history and clinical findings of two affected soldiers, we discuss Strandberg syndrome with regard to clinical symptomatology, pathogenesis, hereditary behaviour, differential diagnosis and prognosis. Electron optical as well as histological studies and HLA-type are presented.

Adult↗
PubMed1984

[Clinical variability of polyvinylpyrrolidone dermatosis].

Several pharmaceutics on the market contain polyvinylpyrrolidone (PVP). As the high-polymeric parts of the PVP molecules cannot be eliminated after parenteral or subcutaneous application, they accumulate in the organism. PVP residues in the dermis cause a considerable variability of skin changes, ranging from deposits nearly without reactions up to swelling, papules, granulomas and pseudotumors.

Dermatitis, Contact↗
PubMed1984

'Composites'--an aberrant structure of the collagen fibril.

Ultrastructural investigations are presented concerning the 'composite'-like collagen changes in different kinds of connective tissue diseases. Most impressing findings were observed in processes causing an extensive elastotic degeneration. The morphology of the 'composite'-like collagen changes is described, and some hypotheses are discussed with regard to the pathomechanism of their generation.

Collagen↗
PubMed1983

[Congenital bullous erythroderma ichthyosiforme in 4 generations. Histological, electronmicroscopy findings and HLA typing].

Epidermolytic hyperkeratosis is a rare hereditary disease characterized by change of the dermatological signs with advancing age of the patients. At birth as well as during childhood, epidermolysis and blister formation are found; later the general picture of the disease presents horny hystrix-like lesions especially on the flexor parts of the extremities. Bullae become rare in adult life, vulnerability, however, remains. Here we report on 21 patients out of a 38-member family showing the above mentioned clinical findings. Electron-optical as well as histological studies are presented. For the first time HLA-type is reported.

Adult↗
PubMed1983

[Gottron's erythrokeratodermia congenitalis progressiva symmetrica with atypical involvement of nails in the sense of pachyonychia].

Erythrokeratodermia congenitalis progressiva symmetrica Gottron (ECPSG) is a rare hereditary disorder characterized by plaques of hyperkeratosis on an erythematous basis. The onset of the disease occurs predominantly in early childhood. Morphological and histological findings give hint for the diagnosis. Ultrastructural findings as well as HLA type (A2, A9, B18) are reported. ECPSG connected with pachyonychia has been observed for the first time.

Adolescent↗
PubMed1983

[Cytidine monophosphatase (CMPase), a transport hydrolase of membrane-bound glycoconjugates].

Membrane bound glycoconjugates (glycoproteins, -lipids and proteoglycans) of the plasmalemmaa and of the cytoplasmic membrane tube system are responsible for essential cell function. Accordingly it is necessary to keep them in a proper functional state. Our results indicate a possible involvement of cytidine monophosphatase (CMPase) in these events. Study is published by Novikoff (1967) and Clermont et al. (1981) the CMPase being a hydrolase which participates to a major part in the sequestration process and vesicular packaging from the GERL system. The enzyme is carried on towards the cell surface bound to the membrane of transport vesicles. Our observations suggest a possible incorporation of glycoconjugates in the plasmalemm by involvement of CMPase. In addition, the enzyme takes part in the endocytotic reuptake of glycoconjugates having lost their complete function with recycling and rebuilding in the GERL and Golgi apparatus. By using antigen provoked mononuclear and neutrophilic leucocytes the membrane bound response of CMPase is seen to be very distinct. The same is true for enterocytes exposed for a short-time ischemia. A strictly localized appearance of the CMPase in close vicinity to the couplings of short-time ischaemic muscle fibres in apparently of relevancy fr restructuring and availability of membrane bound glycoconjugates. This suggest a direct influence on the mechanism of excitation-contraction couplings of skeletal muscle fibres.

Animals↗