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Biomedical subjects

G Salvi

Publications and source records attributed to G Salvi.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Ophthalmological aspects in allogenic bone marrow transplantation: Sjögren-like syndrome in graft-versus-host disease.

PURPOSE: A major complication of allogenic bone marrow transplantation (BMT) is graft-versus-host disease (GVHD), characterized principally by involvement of the eyes, producing a Sjögren-like syndrome (SLS). This study assessed the predictive role of the eye involvement in the onset of GVHD. METHODS: Thirty-five patients transplanted for hematological malignancies were routinely examined for ocular manifestation of dry eye. Examination includes the Schirmer I test, break-up time, Lissamine Green staining, fluorescein test, lactoferrin test and impression cytology. A threshold was established for quantitative analysis of SLS. RESULTS: Fifteen of 35 patients (40%) developed SLS during long-term follow-up. Ten of these (77%) developed acute or chronic GVHD. CONCLUSIONS: The possible etiology of SLS includes three factors: total body irradiation, ocular toxicity of chemotherapy and GVHD. A correlation was found between poor-prognosis GVHD and the occurrence of SLS.

Adult↗
PubMedDate not supplied

[Gastroduodenal stress ulcer. A pediatric case report].

The Authors describe a case of a post rubella encephalitis in a six year old child complicated by severe haemorrhagic episodes due to a duodenal stress ulcer. Despite H2 receptors antagonist therapy, surgery has been required to control the repeated bleeding episodes.

Child↗
PubMedDate not supplied

New trends in the radiotherapy of brain neoplasms.

Improved local control and survival within an acceptable toxicity represents a difficult goal in the treatment of brain neoplasms. There are numerous staging problems and alternative therapies, therefore comparisons are difficult. Treatment planning optimization, especially with dedicated software in stereotactic radiotherapy and the use of sophisticated systems of dose delivery as multi-leaf collimator, micro-multi leaf collimator, intensity-modulated tomotherapy etc. suggests a broad range of therapeutic options with the predominant use of: a) computers; b) different strategies as high dose gradient and combination with chemotherapy; c) higher costs for specialist equipment and activity.

Brain Neoplasms↗
PubMedDate not supplied

Head and neck cancer: new trends in research and clinical practice.

Head and neck cancer represents an interesting subject of research in the third millennium. Apart from basic research (molecular biology, genic therapies etc.) which it shares with other neoplasms, a number of studies are in progress in the field of clinical research. In particular trials of combined radiation and chemotherapy with one or several drugs are being carried out and they will certainly provide definitive results in the field of clinical application. Further acquisitions will be provided by the studies on non conventional dose fractionation and the application of intensity modulated radiotherapy. Finally, the first studies on chemoprevention in patients with malignant or precancerous lesions of the head and neck will be soon concluded.

Head and Neck Neoplasms↗
PubMedDate not supplied

[A case of human dirofilariasis (D. repens) of the spermatic cord].

A 52 year old man, living in the province of Trapani (Sicily), presented with right hydrocele and slight orchialgia. The patient underwent epididymectomy and resection of T. vaginalis. The "tunica" was involved by a granulomatous process, containing a parasite of genus Dirofilaria (D. repens). Dirofilaria repens is a filarial nematode. Dogs, foxes and cats are the definitive hosts and principal reservoirs of the parasite. In humans the parasite dies before reaching sexual maturity and the result is an inconspicuous granulomatous reaction in the subcutaneous tissue. S. Pampiglione et al. (Cattedra di Parassitologia Veterinaria dell'Università di Bologna-Italy) reported from 1971 more than 30 cases of human Dirofilariasis in Italy, suggesting that the parasite is able to migrate from the inoculation site to other districts (lung, eye etc.). The case is exceptional for the localization of the parasite (never reported) and can contribute to a better knowledge of the disease.

Animals↗
PubMedDate not supplied

[Indications for esophagogastroduodenoscopy (EGD) in the octogenarian: a first-step investigation?].

Esophagogastroduodenoscopy (EGD) is the most reliable diagnostic method to evaluate the upper digestive tract. It is conceivable that a rising number of very aged patients with dyspeptic symptoms will come to observation as a consequence of the increasing mean age of the population; however there is not yet a complete agreement to submit patients with extremely advanced age to an EGD. The aim of this study is to evaluate the indications and the tolerance of the upper digestive endoscopy in patients more than 80 yrs old. EGD. Two hundred sixteen patients (mean age 84.5 yrs) were submitted to an EGD without any sedation and pharyngeal anesthesia in one-third of cases. Indications were specific symptoms in 52.3% and aspecific in 47.7%. Tolerance was very good with only one case requiring heavy sedation. We do not report complications. As expected, a high percentage of proliferative lesions were found, but also phlogistic and peptic lesions were very common. X-Rays were performed in 20% of cases but false negatives were observed in 11.6% and false positive in 23.2%. Moreover radiological procedures were poorly tolerated in a relatively high percentage of cases. Our experience showed that: 1) EGD is a very well tolerated and safe procedure in patients with very advanced age; 2) unsuspected lesions are found even in patients with aspecific symptoms; 3) EGD should be proposed as a first study in dyspeptic very aged patients being more tolerated and more reliable than X-Rays in these cases.

Aged↗
PubMedDate not supplied

[Hypertrophy of the pigment epithelium in familial intestinal polyposis].

Recently a few cases of pigment epithelium hypertrophy associated with Gardner's syndrome and familial polyposis have been described. The authors report the results of an ophthalmoscopic investigation on patients affected by Gardner's syndrome and familial polyposis. The importance of the ophthalmoscopic finding associated with this type of intestinal pathology is discussed.

Adenomatous Polyposis Coli↗