Study of red blood cell (RBC) deformability in hemodialysis (HD) patients.
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Biomedical subjects
Publications and source records attributed to G Salvi.
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To evaluate the role, if any, of alpha-1-ag in the pathogenesis of dislipidemia in hemodialysis patients, serum alpha-1-ag levels were measured in 31 patients during maintenance hemodialysis. The mean serum alpha-1-ag concentration was higher in the dialysis patients (117.58 +/- 36.65) than in controls (98.32 +/- 19.5) (p greater than 0.05), with an unexplained significant difference between males and females (p less than 0.01). Serum alpha-1-ag levels were above normal in 6 patients (19.3%) and below normal in no one. A further significant increase in the mean alpha-1-ag concentration was observed following a single dialysis (132.19 +/- 37.12) (p less than 0.001). No correlation with dialytic age or underlying nephropathy was noted. Serum alpha-1-ag levels did not correlate with serum triglycerides, nor was there any difference between normotriglyceridemic and hypertriglyceridemic patients. Therefore it seems unlikely that a deficit in alpha-1-ag due to uremia per se or secondary to dialysis may have a role in pathogenesis of dislipidemia in uremic patients during maintenance hemodyalysis.
Serum ferritin, measured by radioimmunoassay in 65 dialysis patients (mean time of dialysis 38.9 months), was significantly higher (247.9 +/- 224.5 ng/ml) than in controls (p less than 0.001), inversely correlated with dialytic age (p less than 0.05), and had no difference as far as sex or underlying nephropathy were concerned. With regard to the other hematological parameters, serum ferritin correlated inversely with total transferrin and directly with percentage of total transferrin only. In 28 patients, an intravenous iron load (0.6 g in one month) induced a further increase in serum ferritin (p less than 0.001), rather disomogenous and not clearly correlated with initial levels. The change in hemoglobin concentration after iron administration was in close relationship with initial serum ferritin levels (r = -0,72, p less than 0.001). A significant increase in hemoglobin could be detected in all the patients with serum ferritin less than 65 ng/ml and in most patients with serum ferritin less than 160 ng/ml, while hemoglobin change was negligible when serum ferritin levels in dialysis exceeded this value. Thus, although serum ferritin levels in dialysis patients may reflect not only iron overload but also an abnormal metabolism, serum ferritin measurement remains a reliable guide to iron requirement. We suggest maintaining serum ferritin levels between 65 and 160 ng/ml, to avoid iron stores depletion and on the contrary, iron overload.
114 subjects with esotropia and blockage syndrome were observed. Diagnosis was based upon clinical and EOGraphical data. Tendon lengthening with fascia lata was performed mono or bilaterally on medical recti, with or without associated resection of the external recti. The residual angle of strabismus and the effect on the blockage were measured to evaluate the results. Those seemed to be generally favourable. The AA. discuss upon the action of this kind of surgery on the muscular dynamic.
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Competitive hybridization of ribosomal RNAs was used to estimate similarities of nucleotide sequences between species of Angiospermae and Gymnospermae. Similarities have been measured with respect to Cucumis sativus. In Angiospermae the nucleotide sequences are highly conserved except in the species of the family of Compositae, where the percentages of similarity are clearly lower. In the Gymnospermae the lowest similarity has been observed with Torreya californica. A relationship is hypothesized between conservation of rRNA nucleotide sequences and evolutionary position of the species.
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