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G Sakamoto

Publications and source records attributed to G Sakamoto.

At least 109 records · Page 6Linked to original sources
PubMed1984

[So-called carcinosarcoma of the breast--report of 4 cases].

Four cases of so-called carcinosarcoma of the breast were studied histopathologically. The patients were females aged 44, 37, 44 and 77 who were admitted to the Cancer Institute Hospital for breast tumors. Histologically, the tumors showed proliferation of sarcomatous cells with relatively small amounts of papillotubular carcinoma or scirrhous carcinoma. There were transitions between the sarcomatous portion and carcinoma. Two cases showed squamous metaplasia merging into the sarcomatous component, whereas the other 2 showed transition from adenocarcinoma to sarcomatous element. Lymph nodal metastases in 2 cases were papillotubular carcinoma. One patient died of lung and brain metastases, and autopsy revealed only sarcomatous element.

Adult↗
PubMed1984

[Effect of pre-operative biopsy for breast cancer on survival rate].

To study the effect of pre-operative biopsy for breast cancer on the 10-year-survival rate, 1123 cases with single cancer radically operated at the Cancer Institute Hospital between Jan. 1960 and Dec. 1969 were analyzed. The survival rate in 292 biopsied and non-biopsied patients with cancers less than 2 cm in diameter and no lymph node metastasis was not significantly different. There was no difference between incisional- and excisional-biopsied patients. However, the survival rates tended to decrease as the interval between biopsy and radical surgery increased. We conclude that pre-operative biopsy does not worsen the prognosis in patients with breast cancer. Early detection and treatment are of great importance.

Biopsy↗
PubMed1984

[Squamous cell carcinoma of the breast--case report].

A rare case of squamous cell carcinoma of the breast is presented. A 50 year-old female patient suffered from a painful tumor of the right breast 8 years prior to death. The histology of the resected mammary tumour revealed squamous cell carcinoma with an adenocarcinomatous feature in the minority. Malignancy developed in the left lung 5 years after the surgery and formed a huge mass including the pectoral muscle and esophagus. At autopsy, metastases were found in the pericardial sac and liver. Histologically, a prominent well-differentiated squamous cell carcinoma element was identified in the lung, whereas an adenocarcinomatous figure was predominant in the other sites.

Adenocarcinoma↗
PubMed1984

[Breast cancer in Japan--past trend and future prospect].

Breast cancer among Japanese females was characterized by a relatively low incidence and good prognosis. But recently its morbidity is increasing and its biological behavior is changing. The chronological changes and prospective features of breast cancer among Japanese females are follows: 1. Increase of morbidity and mortality 2. Increase of the ratio of poorly differentiated carcinoma and decrease of well differentiated carcinoma 3. Increase of the incidence of lobular carcinoma 4. Increase of the case of the aged females Above items show that breast cancer among Japanese females is becoming westernizing. The case-control study on "breast cancer occurrence and obesity" shows that an obesity of the aged is a significant high risk factor for breast cancer occurrence. There fore, it would be effective that the prevention of overweight at the postmenopausal women to reduce the breast cancer occurrence. The chronological rise of overall 10-year survival rate of operated breast cancer is caused by increasing the ratio of early stage cases. Suggesting an importance of regular self-examination of the breast. Furthermore, it is important to establish an adjuvant therapy without causing side effect for curatively operated cases. Concerning the cancer of the uterus among Japanese females, the chronological occurrence rate of endometrial cancer is increasing, while the death rate of cervical cancer is decreasing.

Adult↗
PubMed1984

[A case report of mastopathy with cartilagenous and osseous metaplasia].

A case of mastopathy with cartilagenous and osseous metaplasia is reported. The patient is a 57-year-old Japanese woman complaining of a tumor measuring around 1.2 cm in diameter near the nipple of the left breast. The xeromammographic diagnosis was adenosis with calcification. Histological examination identified an intracystic tumor composed of papilloma and adenosis with cartilagenous and osseous metaplasia. This is the first Japanese case of its kind.

Breast Neoplasms↗
PubMed1984

[Previous abortions exert favourable effects on the prognosis of breast cancer patients].

The effect of previous abortions, both induced and spontaneous, on the prognosis of breast cancer patients was analysed, applying the hazard regression model of 1190 radically mastectomized Japanese women. The 10-year disease-free survival rate of 800 patients without abortion, 312 with one or two abortions and 78 with 3 or more abortions was 64.8%, 69.8% and 77.3%, respectively. Previous abortions had a significantly favourable effect on the prognosis when the effects of 8 other co-variants were taken into account (p = 0.008). Histologic findings on resected materials showed that patients with previous abortions had a higher incidence of well-differentiated breast cancer (25%) than those without abortions (19%) (p = 0.026). The former group had significantly less metastasis to visceral organs (11.8%) than the latter (17.5%) (p = 0.011) when the first recurrence site was investigated.

Abortion, Induced↗
PubMed1983

[Case of carcinoid tumor of the breast].

A 74-year-old female with a left breast mass was admitted to the Cancer Institute Hospital and underwent mastectomy. Upon study of a frozen section, a diagnosis of breast carcinoma was made. Histopathological examination revealed a non-invasive tumor whose slightly eosinophilic rich cytoplasm was positive for PAS and Alcian-green staining and argyrophilic staining. The tumor showed medullary arrangement, partly with glandular and rosette-like structures. Electron microscopically, many dense core granules (170 +/- 30 nm in diameter) were diffusely distributed in almost all the tumor cytoplasm, they were thought to be neurosecretory granules. A diagnosis of mucocarcinoid of the breast was made. The patient experienced no dyshormonal disorder during the course of the disease and is alive and well without recurrence.

Aged↗
PubMed1983

[Visceral metastasis in 135 cases of breast cancer: evaluation at autopsy].

We examined the distribution and frequency of metastasis in 135 breast carcinoma cases autopsied between 1946 and 1981 at the Cancer Institute, Tokyo, and studied the relationship between the results and various factors such as histological type, patient age, therapy and clinical course. Breast carcinoma metastasizes more widely and more frequently than other malignant tumors; there is a high rate of metastasis to the bone, adrenals, opposite breast, and thyroid. Medullary tubular carcinoma metastasizes more highly than other histological types. The frequency of metastasis is higher in the younger age group and in patients irradiated to the primary sites. There is little correlation between the frequency of metastasis and total duration.

Adult↗
PubMed1982

Epidemiology of familial predisposition for breast cancer in Japan.

The physical and reproductive traits known to be risk factors for breast cancer were correlated with familial predisposition for this disease by the use of hospital records of 3,867 patients with breast cancer, of whom 186 had one or more relatives with breast cancer and were called "familial patients." Various characteristics in the total series of patients were compared with familial patients matched for year of birth. The mean age at menarche was significantly less in familial compared with the total series of patients, especially for premenopausal patients; however, no difference was observed in the mean age at marriage between the two groups. Familial patients were slightly taller as compared to the total series of patients, but no difference was detected in body weight between the two groups. Because age at menarche and the stature are highly correlated, they may be influenced by an underlying common hormone effect that may influence the familial nature of breast cancer.

Adult↗
PubMed1978

Primary malignant melanoma of the vagina: study of four autopsy cases with ultrastructural findings.

Four cases of primary malignant melanoma of the vagina in women aged 23, 44, 51 and 65 years are presented. In these 4 cases, thorough clinical and postmortem examinations ruled out the possibility of a primary melanoma elsewhere. The primary tumors showed exophytic growth with superficial ulceration. Three of the melanomas arose from the middle third of the vagina and one from the upper third. Melanin was visible in sections stained with hematoxylin and eosin in 3 of the tumors. In the other one, the first biopsy failed to reveal melanin. However, the second biopsy performed following irradiation showed abundant melanin pigment. Electron microscopic examination of 3 tumors revealed premelanosomes and melanosomes in the tumor cells, thus confirming the diagnosis. Two neoplasms showed atypical histologic features, and only the presence of melanin enabled us to make diagnosis of malignant melanoma. One melanoma was associated with an adjacent widespread intraepithelial component of superficial spreading type indicating its probable mode of origin. All 4 patients died of widespread metastases within 13 months after initial treatment. These 4 cases, in which clinical diagnosis was confirmed by thorough autopsy, strongly indicate that malignant melanoma can arise directly from the vagina.

Adult↗
PubMed1978

Histopathological types of nasopharyngeal carcinoma in a low-risk area: Japan.

NPC in Japan was studied histopathologically by examining 816 NPCs from among 3 338 biopsies from patients with tumours of the nasopharynx and other parts of the upper respiratory system. In addition, a comparative study on NPC among Taiwanese and an immunoserological study were carried out. When comparing histological types of malignant tumours of the upper respiratory tract, poorly-differentiated squamous-cell carcinoma predominated only in those of the nasopharynx. Malignant nasopharyngeal tumours in Japanese patients were characterized by two histological features: predominance of squamous-cell carcinoma, especially of the poorly-differentiated type, and a relatively high frequenty of malignant lymphoma. An analysis of 731 cases of NPC showed that a vast majority (86.7%) were poorly-differentiated and a minority (13.3%) well-differentiated squamous-cell carcinomas. The former included 45.8% spindle-polygonal-cell carcinomas, 26.6% transitional-cell carcinomas ana 14.3% lymphoepitheliomas. Although the transitional-cell carcinomas and lymphoepitheliomas showed a peculiar morphology, it was confirmed that they are of a squamous nature. A comparative study of the histology of NPCs in a high-risk area, Taiwan, and in a low-risk area, Japan, revealed considerable differences between the two groups. Well-differentiated carcinomas were infrequent in both groups but were more frequent in Japanese than in Taiwanese, while the frequency of poorly-differentiated carcinomas, especially transitional-cell carcinomas and lymphoepitheliomas, was much higher among Taiwanese. A seroepidemiological study on the relation of anti-VCA antibody titres to histological type of tumour in 84 Japanese NPC patients revealed that the rate of positivity and the geometric mean of the titres were considerably higher in patients with lymphoepitheliomas. Althougropathological study along this line would appear to be important, since the results obtained in Japanese NPC cases may suggest that EBV genomes in NPC cells vary with the grade of differentiation of NPC.

Age Factors↗
PubMed1977

Circumscribed carcinoma of the uterine cervix, with marked lymphocytic infiltration.

The present study was carried out to investigate a distinctive type of carcinoma of the uterine cervix categorized under the designation as circumscribed carcinoma with lymphocytic infiltration. Grossly this carcinoma is characterized by defined circumscription with a superficial ulceration. A microscropic feature characteristic of this tumor is the presence of a loose fibrillary stroma infiltrated densely and uniformly by lymphocytes throughout the tumor mass. The tumor is arranged in solid cords separated by a lymphoid stroma with evidence of minimal squamous differentiation. The authors picked up 709 patients with carcinoma of the uterine cervix who underwent radical hysterectomy and pelvic lymphadenectomy at the Cancer Institute Hospital, Tokyo, between 1956-1967, without preoperative radio- or chemotherapy. Among them, 39 or 5.5% were identified as this type of carcinoma. Patients with this types of carcinoma had a significantly better prognosis than those with other types of cervical carcinoma of the same stage (p less than 0.05). This favorable prognosis is probably due to the less regional node metastases found in the group. A proposal was made to segregate this particular type of carcinoma from other types of cervical carcinoma on the basis of its morphologic and prognostic distinctiveness.

Adult↗