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Biomedical subjects

G Russell

Publications and source records attributed to G Russell.

At least 199 records · Page 11Linked to original sources
PubMed1981

Direct immunofluorescence in the diagnosis of Legionnaires' disease.

Over a 2 1/2 year period, 61 clinical specimens from 41 patients with pneumonia of uncertain etiology were evaluated for the presence of Legionella pneumophila (serogroups 1 to 4) by immunofluorescent antibody techniques. In 13 of 19 patients with Legionnaires' disease, the diagnosis was established by fluorescent antibody (FA) staining of lung biopsies, pleural fluids, or respiratory tract secretions. In the 19 patients with Legionnaires' disease, the diagnosis was confirmed by isolation of L pneumophila by in vitro culture techniques in five or by measurement of serum antibody titers in 17. Although the FA staining technique was of limited sensitivity (68 percent), it was highly specific: no patients with non-Legionnaires' pneumonia had a false-positive fluorescent stain. In addition, the FA staining of lung tissue was positive only when performed during the first nine days of antimicrobial therapy and when an acute bronchopneumonia was noted histologically. In cases of a nonspecific interstitial pneumonitis, FA stain was always negative, and the diagnosis could be confirmed only by serum antibody measurements. Tests for serogroups 1 to 4 with a polyvalent conjugate showed that L. pneumophila serogroup 1 was the predominant strain detected in pneumonia of uncertain etiology in the Detroit area.

Biopsy↗
PubMed1981

Particle size and concentration adjustments of tomato products for Howard mold count.

The present AOAC method for mold counts of tomato products (44.096) provides no inter-product standardization of concentration among juice, sauce, paste, puree, and catsup; no intra-product standardization of concentration for juice, sauce, and catsup; and no adjustment for degree of comminution. Use of the official method, therefore, could result in an artificially increased mold count for products which have undergone extreme comminution. A new method was developed to adjust all products to the same concentration and grind them to a uniform particle size, thereby ensuring comparable mold counts on products produced by different processes. Collaborative study results showed equal repeatability for both the official and the proposed methods and a lower coefficient of variation for the proposed method.

Food Microbiology↗
PubMed1980

Gastric emptying of Caloreen meals in the newborn.

The gastric emptying of 10% solutions of glucose and of Caloreen, a glucose polymer, was compared in 16 newborn infants. Caloreen left the stomach more rapidly than glucose on all but one occasion. This has potential advantages to infant feeding.

Dietary Carbohydrates↗
PubMed1980

Oral tolerance of Caloreen in babies.

Serial plasma glucose concentrations were compared in 20 infants of low birthweights (< 2500 g) after test meals of 10% solutions of Caloreen and glucose. After Caloreen, the rise in plasma glucose concentration occurred more slowly but was better sustained, and hyperglycaemia was seen less often than after glucose. Caloreen may be preferable to glucose as a carbohydrate source in the prophylaxis and treatment of neonatal hypoglycaemia.

Blood Glucose↗
PubMed1980

Glucose tolerance in the heavy-for-date neonate: a pilot study.

Intravenous glucose tolerance tests were performed on 12 infants with birth-weights above the 95th centile (corrected for maternal height, weight and social class and for the gestation, sex and birth rank of the infant). In 4 infants the glucose disappearance rate (kt) was abnormally high (> 2.05), but glucose tolerance and birth weight were not correlated. However, enhanced glucose tolerance was significantly and positively correlated with obesity in the infant. Although these infants are biochemically abnormal, there is no evidence that this abnormality constitutes a clinical hazard.

Birth Weight↗
PubMed1979

Bulimia nervosa: an ominous variant of anorexia nervosa.

Thirty patients were selected for a prospective study according to two criteria: (i) an irresistible urge to overeat (bulimia nervosa), followed by self-induced vomiting or purging; (ii) a morbid fear of becoming fat. The majority of the patients had a previous history of true or cryptic anorexia nervosa. Self-induced vomiting and purging are secondary devices used by the patients to counteract the effects of overeating and prevent a gain in weight. These devices are dangerous for they are habit-forming and lead to potassium loss and other physical complications. In common with true anorexia nervosa, the patients were determined to keep their weight below a self-imposed threshold. Its level was set below the patient's healthy weight, defined as the weight reached before the onset of the eating disorder. In contrast with true anorexia nervosa, the patients tended to be heavier, more active sexually, and more likely to menstruate regularly and remain fertile. Depressive symptoms were often severe and distressing and led to a high risk of suicide. A theoretical model is described to emphasize the interdependence of the various symptoms and the role of self-perpetuating mechanisms in the maintenance of the disorder. The main aims of treatment are (i) to interrupt the vicious circle of overeating and self-induced vomiting (or purging), (ii) to persuade the patients to accept a higher weight. Prognosis appears less favourable than in uncomplicated anorexia nervosa.

Adolescent↗
PubMed1979

The effect of posture on ventilation and lung mechanics in preterm and light-for-date infants.

The effect of right lateral, supine, and prone postures on ventilation and lung mechanics was studied in 23 healthy newborn infants, ten preterm and 13 term, "light-for-date," In the preterm group, tidal volume, minute volume, elastic work, inspiratory viscous work, total viscous work, and the total work of breathing were significantly greater in the prone position than in the supine position. Results obtained in the lateral position did not differ significantly from those in the prone or supine positions. Posture did not significantly affect tidal volume or lung mechanics in the light-for-date infants. The prone position is suggested to be the optimum nursing posture for healthy preterm infants.

Female↗
PubMed1977

Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor.

Human peripheral blood lymphocytes incubated in culture for 1 to 3 days at 37 degree C, but not at 4 degree C, release a soluble factor which can stimulate, up to 400-fold, collagenase production by isolated, adherent, rheumatoid synovial cells. Production of lymphocyte factor is enhanced by phytohemagglutinin or concanavalin A. By gel filtration the factor has an apparent molecular weight of about 12,000.

Arthritis, Rheumatoid↗
PubMed1977

Vater syndrome: hypothesis and report of two further cases.

Two cases are reported of the association of a group of abnormalities defined as the Vater syndrome, together with a hypothesis, based on the presence of normal cell death during embryogenesis, on how they occur together so frequently. Although the mechanism of normal cell death is unknown, adjacent cells are probably affected sublethally and subsequently recover. A teratogenic situation introduced simultaneously with the occurrence of normal cell death may further diminish the viability of those adjacent cells, causing increase in the necrotic zone and loss of both normal tissue and growth potential.

Abnormalities, Multiple↗
PubMed1977

Quality of survival after severe birth asphyxia.

Thirty-one children who survived severe birth asphyxia defined by a 1-minute Apgar score of 0, or a 5-minute Apgar score of less than 4, have been seen at age 5 to 10 years for neurological and psychological assessment. Their progress has been compared with that of controls matched for sex, birthweight, gestational age, and social class. 29(93%) of the 31 asphyxiated group and all the controls had no serious neurological or mental handicap. 2 were severely disabled and mentally retarded. Detailed studies of psychological function showed no significant differences between the two groups. 2 apparently stillborn infants have made normal progress. It was not possible to identify any perinatal factor which predicted the occurrence of serious handicap with certainty. We considered that the quality of life enjoyed by the large majority of the survivors was such as to justify a positive approach to the resuscitation of very severely asphyxiated neonates.

Asphyxia Neonatorum↗