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Biomedical subjects

G Russell

Publications and source records attributed to G Russell.

At least 181 records · Page 10Linked to original sources
PubMed1984

Effects of jaundice and phototherapy on gastric emptying in the newborn.

Gastric emptying rate was measured in term infants without jaundice, with mild jaundice, and with moderate jaundice before and after phototherapy. Gastric emptying was significantly delayed in the moderately jaundiced infants (serum unconjugated bilirubin 233-332 mumol/l) but returned to normal following phototherapy. Mild jaundice (serum unconjugated bilirubin 170-204 mumol/l) had no effect on gastric emptying. Jaundice appears to inhibit gastric emptying, and phototherapy influences emptying indirectly by lowering serum bilirubin concentration. This effect is likely to be of clinical significance in a small minority of jaundiced infants.

Bilirubin↗
PubMed1983

Acute renal failure due to continuous rifampicin.

We describe the clinical and pathological features of acute renal failure which occurred in a patient receiving a first course of antituberculous therapy, including daily rifampicin. Renal biopsy specimens demonstrated an interstitial nephritis. The renal lesion resolved three weeks after the cessation of rifampicin, as evidenced by improvement in renal function and the return of nuclear magnetic resonance tomographic studies to normal. This is only the fifth reported instance of renal impairment following continuous rifampicin therapy, despite widespread use of the drug in a daily dose. The possible toxic interaction of rifampicin and antituberculous drugs which are excreted predominantly by the kidneys is also described.

Acute Kidney Injury↗
PubMed1982

Writing and dyslexia--an historical analysis.

Writing was devised by man, and an historical survey shows that is gradually became perfected over 3500 yr towards increasing phonetisation and simplification. It is postulated that this development and the characteristics of the perfected alphabetical scripts indicate a process adaptive to man's linguistic faculties. The exceptional forms of writing, such as Chinese, remained out of reach of the masses of the people. The hypothesis is put forward that the same process might be maladaptive to a minority of children deficient in the requisite linguistic abilities: in a literate society they would suffer from disorders of reading.

Child↗
PubMed1982

Impairment of phonetic reading in dyslexia and its persistence beyond childhood--research note.

A previous analysis of the historical development of writing towards progressive phonetisation gave rise to the hypothesis that disorders of reading arise from a defective processing of spoken sounds. Sixteen adolescent and adult dyslexic patients were studied, 10 of whom had been followed up from childhood. A newly devised test of phonetic reading proved superior to the Schonell reading test in distinguishing dyslexics from normals, and mirrored the original severity of the disorder. A phonetic writing test was less useful. The findings support the view that dyslexia is due to a defect of verbal processing which may persist beyond childhood.

Adolescent↗
PubMed1982

Unexplained diarrhoea and failure to thrive in 2 siblings with unusual facies and abnormal scalp hair shafts: a new syndrome.

A family is described in which 2 siblings born to healthy parents presented with abnormal facies, persistent diarrhoea, and early death. Exhaustive pathological and biochemical investigations failed to find a cause. The scalp hair of both babies had an abnormal amino-acid composition, and presented an appearance that was unique on scanning electron microscopical examination; this fact and the clinical picture probably represents a new syndrome.

Amino Acids↗
PubMed1982

Fat as an energy supplement for preterm infants.

The absorption and utilisation of dietary fat as an energy supplement was studied in 15 healthy preterm infants. They were given two formulae for periods of one week. The standard low solute feed supplied 6 g fat and 476 kJ (114 cal) per kg. The high energy feed supplied 10 g of the same fat and 623 kJ (149 cal) per kg. Fat supplementation resulted in increased absorption (significantly higher chylomicron levels) without steatorrhoea or metabolic disturbance, apparently unchanged differential absorption of fatty acids, and a significantly higher rate of weight gain (mean 25.9 +/- 4.6 compared with 20.3 +/- 4.4 g/24 h). A high energy formula prepared with supplements of complex dietary fat is therefore of potential value in ensuring the adequate nutrition and growth of preterm infants.

Animals↗
PubMed1981

Size exclusion chromatography of liposomes on different gel media.

Unchanged and negatively and positively charged liposomes of egg lecithin were prepared by sonication and chromatographed on three different gel media. The column effluent was investigated by turbidimetric measurements. The operational parameters were selected to obtain baseline separation of the liposomes. Liposome peaks were fractionated and identified by their Kav (distribution coefficient) values. Baseline separation into two fractions was obtained with cross-linked dextran gel, and three fractions were obtained with cross-linked agarose gel.

Chromatography, Gel↗
PubMed1981

Antiperinuclear factor and keratin antibodies in rheumatoid arthritis.

Tests for antiperinuclear factor (APF) demonstrable by indirect immunofluorescence (IF) on smears of human buccal mucosal cells and for antibodies to keratin (AKA) detected on cryostat sections of rat oesophagus were performed on serum from 102 cases of rheumatoid arthritis (RA) and 117 controls. APF was detected in 92% of the cases of RA; positive tests obtained with non-RA sera were generally weaker than those given by the RA group, and the antibody in both RA and non-RA serum was predominantly IgG class. The difficulty in obtaining suitable substrate material previously reported was confirmed, and only 2 satisfactory donors were identified among 27 individuals tested. The incidence of keratin antibodies detected was found to be related to the site from which the tissue was taken; low oesophagus provided the best discrimination between RA and controls (51% and 5% positive respectively), and cardia of the stomach gave the highest incidence of staining in all groups. A laminar staining pattern was seen with most positive sera, but occasionally the keratinised layer was diffusely stained. The presence of AKA showed a marked correlation with both IgM rheumatoid factor and increased Clq binding in RA, but APF did not.

Antibodies↗