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Biomedical subjects

G Reuter

Publications and source records attributed to G Reuter.

At least 217 records · Page 12Linked to original sources

[Excretion of organic compounds bei microorganisms in presence of diphenylamine].

Diphenylamine (DPA) causes an increased leakage of organic compounds with resting cells of Candida guilliermondii, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus already after a treatment of 1 h. The leakage depends both on the concentration of DPA and the duration of the treatment. Moreover, DPA influences the composition of the leaked ninhydrine-positive compounds. After 20 h of treatment an increased release of mannan and ribose is observed in addition to the stronger leakage of ninhydrine positive compounds. With regard to the relation between structure and activity of DPA, the activity of 21 compounds was investigated. The two apolar phenyl groups as well as the secondary amino group being able to form ionic bounds are essential for maximal activity. A disturbance of the function of the cell membrane caused by DPA is discussed.

Acetates↗

[Physiology and biochemistry of streptomycetes. III. Incorporation of D-glucose-u-14C in paramomycin as indicator of antibiotic biosynthesis by Streptomyces albus var. metamycinus nov. var].

Paromomycin was isolated from culture filtrates of Streptomyces albus var. metamycinus nov. var. after feeding the growing cultures with D-glucose-u-14C. From the different incorporation rates conclusions concerning different features of the paromomycin biosynthesis (utilization of the carbon source, proportional and disproportional changes of the rates of synthesis) could be drawn. Uptake and metabolism of glucose are discussed.

Culture Media↗