A bioequivalence study on retarded formulations of carbamazepine tablets.
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Biomedical subjects
Publications and source records attributed to G Rabending.
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A classifier based on the linear regression model was developed to automatically detect sharp transients in EEG, matching the definition of spikes and sharp waves accepted by IFSECN. Practical applications proved the accuracy of the method which succeeded in detecting 84% of sharp transients previously found by an experienced electronencephalographer. Computerized search for sharp transients in EEG records will be particularly useful in long term EEG records obtained from epileptic patients.
Investigating the specific of psychic performance disorders in epileptics structural aspects in addition to quantitative performance differences are considerable. We compared psychometrically obtained performance structures of epileptic children and adults and of parallelised healthy control persons. It became evident, that the performance differentiation hypothesis is to corroborate also in epileptic patients. The psychic performance structure of epileptics is characterized by a lower differentiation level of the basis functions underlining the performances. Our factor analytic investigations emphasize the importance of deceleration of psychic/psychomotoric speed in epileptics as primary basic disorder.
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Case report of a 35 years old patient, who, without previous history of epilepsy, within two years experienced two long-lasting psychotic episodes due to non-convulsive status epilepticus with complex partial seizures. During the second psychotic episode she developed ictal vegetative phenomena such as profuse sweating, flush, apnoea, and, above all and most alarming, periods of severe bradycardia and asystolia with clinical signs of syncope. Ictal asystolia, though being an uncommon sing of epileptic seizures, may be one cause of sudden unexpected death in epileptics.
We examined 49 normal intelligent epileptic and parallelised in sex, age and intelligence just as much healthy and 14 minimal cerebral damaged children without seizures. Using a psychological test battery psychic/psychomotor speed, flexibility/preservation proneness, memory span and memory and concentration were registrated. Besides reduced memory performances we found a deceleration of psychic/psychomotor speed as primary basic disorder within the performance structure of epileptic children analogous to our previous examined adults. The tridimensional comparison suggests remarkable psychopathological differences among the two groups of patients.
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In a series of 74 experiments in a double blind study, 25 healthy test persons were medicated with a single dose of Clomipramin, Desipramin, Imipramin, Diazepam, Carbamazepin, Haloperidol, and a placebo. At the end of one hour, and again at the end of three hours, an EEG was made whose frequency analysis revealed significant changes in about half the test persons. The antidepressives induced an increase in the theta waves, the slow alpha waves, and the slow beta waves, and a decrease in the fast alpha waves. The factors influencing the EEG are discussed.
A single dose of Clomipramin, 50 mg; Amitriptylin, 50 mg; Desipramin, 50 mg; Imipramin, 50 mg; Diazepam, 10 mg; Carbamazepin, 200 mg; Haloperidol, 3 mg; were each administered orally, and Clomipramin, 25 mg was administered intravenously, and reaction times were measured and compared with those obtained after administering a placebo. The statistical examination was conducted using Wilcoxon's test. In the case of Amitriptylin, Diazepam, and Haloperidol, there was a statistically significant reduction in the reaction times.