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Biomedical subjects

G Raabe

Publications and source records attributed to G Raabe.

At least 37 records · Page 2Linked to original sources
PubMed1989

Pattern of oral cytokeratins. III. SDS-electrophoretic analysis and immunoblotting of cytokeratins in leukoplakias and squamous cell carcinomas of the oral mucosa.

The frequency of the occurrence of cytokeratins analyzed SDS-electrophoretically in 20 leukoplakic lesions and 14 squamous cell carcinomas of the oral mucosa has shown a picture of "restlessness" with some quantitative, some qualitative deviations from the locally normal pattern of cytokeratins. In most cases the basic pattern typical for the oral mucosa was still recognizable, except for three highly undifferentiated carcinomas. The variations of the cytokeratin pattern existed independently of the clinical form of leukoplakia and of its histological degree of dysplasia. The striking findings in some, but not all cases were: --the presence of cytokeratin no. 18 as a major component which normally appears rarely and faintly, and of cytokeratin no. 19, which is not normally detectable electrophoretically within the whole oral mucosa; --the absence of cytokeratins no. 1-3 despite of the cornification which was reliably proved by histology; --the appearance of the proteins having molecular mass values of 42 kDa and less which very probably may be the products of partial keratinolysis as evidenced by immunoblotting with monoclonal and polyclonal antibodies to cytokeratins. Among these proteins a proteolytically modified cytokeratin no. 19 of only 38 kDa was found.

Antibodies, Monoclonal↗
PubMed1989

Paracentric inversion 11.

A new familial case of paracentric inversion of chromosome 11 inv(11)(q21q23.3) ascertained by multiple abortions in a female carrier is presented. A review of the literature shows 19 further cases of paracentric inversion 11. According to the different breakpoints, the inversions of the long arm of chromosome 11 may be classified into three types.

Abortion, Habitual↗
PubMed1989

A new case of pericentric inversion 20.

A prenatal diagnosis from a chorionic villi biopsy revealed a pericentric inversion of chromosome 20. The child's father also carries the inverted chromosome. The breakpoints p13q11.2 differ for 4 of the 5 published cases of inversion 20.

Adult↗
PubMed1988

Action of chronic peracetic acid (wofasteril) administration on the rabbit oral mucosa, vaginal mucosa, and skin.

In a long-term experiment on rabbits 0.2% peracetic acid (0.5% Wofasteril) was distributed upon the dorsal skin, the oral and the vaginal mucosa 3 times per week for 12 months. Each type of tissue was applied 153 individual doses. The histological examinations did not yield dysplasias in the sense of a carcinogenic action of peracetic acid. Despite the very high dosage as it will never be demanded in therapeutical measures, the mucosal tissues under study neither showed inflammations nor scar formation after 12 months of administration. Merely in the dorsal skin a loss of minute accessory hairs in the animal fell was observed. From morphological points of view it seems justified to extend the indication of 0.2% peracetic acid (0.5% Wofasteril) to the mucosal membrane for preparatory arrangements of surgical interventions and for therapeutical measures in bacterially induced inflammatory processes. Clinical testing can be recommended. Before permanent use of peracetic acid for hand disinfection the possible hazards of depilation must be tested dermatologically.

Acetates↗
PubMed1988

Pattern of oral cytokeratins. II. SDS-electrophoretic analysis of cytokeratins in reactive hyperkeratoses and Lichen ruber planus of the oral mucosa.

In SDS-electrophoresis the hyperortho- and hyperparakeratoses showed cytokeratin patterns fairly similar to those in the normal masticatory mucosa in cases of reactive hyperkeratosis due to mechanical stimulatory action; however, in Lichen ruber planus they agreed only incompletely. The site-specific, normally stably expressed cytokeratins of the mucosa-type concerned were likewise regularly demonstrable in the pathologically changed tissue specimens under study, except cytokeratin no. 1 which is known to be a reliable indicator of keratinocyte cornification merely in orthological but not in pathological conditions. Deviating from the normal cytokeratin pattern in the oral mucosa, a more frequent and more expressed occurrence of cytokeratins no. 17 and 18 was observed in Lichen ruber planus. In 4 extraordinarily reactive hyperkeratoses, among these 2 papillomas the cytokeratins no. 7/13 were present.

Biopsy↗
PubMed1988

[Hyperplasiogenic polyps and risk of stomach cancer].

In 731 hyperplasiogenic polyps which have been removed by endoscopical polypectomy there were 9 polyps with an early cancer and 8 polyps with severe dysplasias (borderline lesions) as well as 1 polyp, in which an advanced carcinoma has been developed. This is the outstanding greatest number of hyperplasiogenic polyps with a malignant transformation. In addition in 9 patients with hyperplasiogenic polyps carcinomas could be discovered, i.e. a rate for malignant developments of 3.7%. It seems that stomachs with multiple polyps are endangered in particular. The recurrence rate of follow-up examinations covering a period of up to 8 years was 36.1%.

Cell Transformation, Neoplastic↗
PubMed1987

Structural rearrangements of chromosome Nr 8 involving 8q12--a primary event in pleomorphic ademona of the parotid gland.

Nine pleomorphic adenomas of the human parotid gland were investigated. Within this series the group of cases having clonal aberrations of chromosome Nr 8 predominates. The occurrence of cases with trisomy-8 and cases with structural rearrangements involving a breakpoint in 8q11-8q13 allows a further subdivision of this group of tumors. Our special interest in this paper is devoted to the latter group. The hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis, leading to activation of a so far unknown oncogene located most likely at 8q12. The translocations to different recipient chromosomes may serve as sign posts to transcriptionally active chromosomal domains in the salivary gland.

Adenoma↗
PubMed1983

Tissue damage in the rabbit oral mucosa by acute and chronic direct toxic action of different alcohol concentrations.

The direct effects of different alcohol concentrations (20%, 40%, 96%) upon the oral mucosa of rabbits were proved in short-term and long-term experiments. The direct toxic action of the alcohol in short-term experiments leads to a local damage of the mucous membrane which is proportional to the degree of alcohol concentration. The alcohol-toxic irritation in long-term studies produced in the course of 12 months a leukoplakia-like epithelial dysplasia (dyskeratosis, keratosis, increased density of the basal layer, slightly increased number of mitotic figures) but there was no loss of polarity of cells and the basement membrane was always intact. No animal developed a spontaneous tumour. The repeated local tissue damage by high local alcohol concentration is in connection with other etiologic factors (excessive tobacco usage) an important initiating factor of cancer of the mouth.

Alcoholic Intoxication↗
PubMed1983

[Histological classification of oral leukoplakia by a classification number].

From 1969 to 1980 the authors examined 587 histological specimens of oral leukoplakia obtained from 424 patients. The histological findings were assessed in classification numbers qualitatively and quantitatively characterizing the subepithelial inflammation, epithelial hyperplasia, keratosis, the grade of epithelial dysplasia an the degree of infiltration when carcinoma had already developed. From this histological classification a classification number resulted which allows conclusions on the prognosis of the leukoplakia under study. Besides the grade of dysplasia also the features of the subepithelial inflammation are important for the prognostic assessment of leukoplakia. The classification numbers are suitable for data processing. In the grading system reported, the most important morphological findings are represented with qualitative and quantitative objectiveness. The classification number leads to more reliable comparison and evaluation of the results obtained by different research groups.

Female↗
PubMed1982

[Results of coloscopic polypectomy in respect of the dignity (author's transl)].

The commonest type of polyps in the large intestine in our series of 506 polypectomies in 262 patients were adenomas (64%) especially tubular adenomas. Severe epithelial atypia being present in 11% of all adenomas and it was three times more discovered in villous adenomas than in tubular forms and with increasing adenomas size. Because severe epithelial atypia could be observed in polyps with diameters less than 5 mm it should be demanded to remove each polyp for an exact histological examination independent of his size. Single forceps biopsies of polyps do not allow the estimation of their further development in view of malignancy.

Adenocarcinoma↗
PubMed1980

Synovial membrane in rheumatoid arthritis: determination of glycosaminoglycans and age-dependent correlations.

From 16 synovial membranes patients with rheumatoid arthritis morphological parameters as well as the GAG distribution pattern have been determined using 2 methods each. The results were checked by discriminant and regression analysis: The total GAG concentration of the synovialis was significantly correlated with the sum of the parameters "fibrin in organization", "granulocytes" "nad "necroses" (acute activity). A highly significant correlation between the age of patients and the severity of chronic morphological alterations (basic activity, especially proliferation) was found. The percentage of CS plus DS was positively correlated with the age of patients as well as with the basic activity of the disease, especially with the proliferation. - Contrary to this, HA was significantly decreased when related to the "chronic" parameters. No correlation could be demonstrated between the GAG components and criteria of the acute activity. The evaluating system of STIEHL and GEILER is to be preferred for obtaining morphologic-biochemical correlations. Furthermore, a diagram is proposed demonstrating the cumulative progression of rheumatoid arthritis in the synovialis as related to the GAG pattern. Its combination with morphological data (scars, proliferation, exudation) may help to describe the development of the disease more acurately.

Adolescent↗