Biomedical subjects

G R Wilson

Publications and source records attributed to G R Wilson.

At least 73 records · Page 4Linked to original sources

PubMed1979

Treatment of luteal phase inadequacy with bromocriptine.

A group of 15 women diagnosed as having luteal phase inadequacy (LPI) and a history of 1--2 years of infertility were treated with bromocriptine continuously for 4 months. Plasma levels of prolactin, progesterone, 17 alpha-hydroxy-progesterone and estradiol were measured by radioimmunoassay in a control month and each of the treatment months. There was no significant improvement in the levels of the steroids over the 4-month period, although the prolactin levels were depressed, and 2 subjects became pregnant during the study.

Adult↗

PubMed1978

Changes in peripheral hormone levels after therapeutic abortion.

Plasma levels of progesterone, 17 alpha-OH progesterone, hPL and beta-subunit hCG were measured in a group of women for 24 h after therapeutic abortion. Progesterone, hCG and hPL levels fell more rapidly than 17 alpha-OH progesterone levels. This might suggest that the main site of synthesis of 17 alpha-OH progesterone is probably in the corpus luteum of pregnancy or that the prolonged half-life of hCG maintains the corpus luteum to secrete longer. Human placental lactogen fell dramatically within 4 h but the hCG level was maintained. This difference probably reflects only the differences in half-lives of these hormones.

17-alpha-Hydroxyprogesterone↗

PubMed1978

Norepinephrine stores in the hypertrophied bovine heart.

Influence of hypertrophy on the cardiac stores of norepinephrine (NE) and epinephrine in different chambers of the heart were studied in calves with experimental left or right ventricular enlargement. In the control calves, concentration of NE was markedly higher in the atrial than in the ventricles, the left atrial body had a lower concentration than the right atrial body. The same was true of the left ventricular tissue compared to the right ventricular tissue. Marked depression of the cardiac NE concentration was observed in all chambers in the groups with right and left ventricular enlargement. The magnitude of changes was roughly related to the severity of the stenosis. Depletions in the concentration of NE were not noticed in the operated nonresponsive calves. By contrast, epinephrine was in small concentrations in control calves, amounting on the average to less than 10% of the amount of NE concentration in the same cardiac tissues. However, alterations in cardiac epinephrine values were not observed in the cardiac tissues obtained from animals with cardiac hypertrophy.

Animals↗

PubMed1978

Haematology, weight and condition of captive red grouse (Lagopus lagopus scoticus) infected with caecal threadworm (Trichostrongylus tenuis).

Red grouse infected with the caecal threadworm Trichostrongylus tenuis developed a mild anaemia. Haemoglobin and albumin levels in the blood fell but there were no significant changes in the number of red blood cells or their size. In infected birds the numbers of circulating eosinophils and heterophils increase, as did the concentration of alpha, beta and gamma globulin. Body weights did not change but muscle masses shrank. Birds that subsequently died had the lowest concentration of haemoglobin and packed cell volumes and the highest counts of eosinophils. The survivors were affected little by worms and their haematology showed small deviations from normal.

Animals↗

PubMed1977

Maternal plasma estrogens after dehydroepiandrosterone-sulfate injection into the fetus.

To study the biogenesis of estrogens by the fetoplacental unit in late pregnancy, dehydroepiandrosterone sulfate was injected directly into the fetus and maternal blood sampled at intervals for 2 hours thereafter. There was no increase of estrone, estradiol, or estriol concentration in the maternal circulation.

Dehydroepiandrosterone↗

PubMed1977

Plasma estrogens and pregnancy-associated plasma proteins: a study of their variability in late pregnancy.

The plasma concentration of several estrogens (unconjugated estradiol and estriol, total estriol, and estriol sulfate) and of the placental proteins hPL and PAPP-C were measured daily for 8 days in 9 subjects. The steroids showed coefficients of variation ranging from 14 to 21%. The proteins were much less variable (PAPP-C 5% and hPL 6%).

Beta-Globulins↗

PubMed1977

Observations on the variability of plasma estriol.

Total plasma estriol and unconjugated plasma estriol were measured daily for 8 days in 9 women during the 38th week of pregnancy. The average coefficient of variation of total estriol concentration was 15.0%; that of unconjugated estriol was 16.5 per cent.

Estriol↗

PubMed1975

Haematology and blood chemistry of the red kangaroo Megaleia rufa in captivity.

Haematology and biochemistry was performed to establish base line values on not less than 30 samples of blood and serum from 10 red kangaroos Megaleia rufa held in captivity. The kangaroos were apparently healthy. Ranges for results were: Haemoglobin 16-18 gm/100 ml, PCV 46-51%, erythrocytes 4.9 - 5.7 times 10(6)/mm3. MCV 86-98 mum3, MCH 30-34 pg, MCHC 34-36%, leucocytes 3.8 - 7.1 times 10(3)/mm3, neutrophils 2.0 - 4.7 times 10(3)/mm3, lymphocytes 1.2 - 2.4 times 10(3)/mm3, monocytes 0.1 - 0.3 times 10(3)/mm3, eosinophils 0.06 - 0.013 times 10(3)/mm3, SGOT 36-43 u/l, SGPT 30-41 u/l, LDH 30-85 u/l, protein 6.0-6.8 g/100 ml, albumin 2.8 - 3.4 g/100 ml, alpha globulin 0.3 - 0.7 g/100 ml, beta globulin 0.7 - 0.9 g/100 ml, gamma globulin 1.7 - 2.3 g/100 ml, albumin/globulin 0.8 - 1.1, Na+ 146-152 mEq/l, K+ 4.6 - 5.6 mEq/l. Rectal temperature was 36.8 +/- 0.3. High haemoglobin may be characteristic of wild animals and of animals which have a high level of muscular activity and large erythrocytes may be representative of marsupials. Haematology as a tool of ecological investigation and its role in future research is briefly discussed. A modified staining technique for performing differential blood cell counts is described.

Alanine Transaminase↗

PubMed1975

Comparative response of castrate and intact male rats to diethylstilbestrol.

Treatment of castrate and intact male rats with DES in the feed was used to note its comparative effect on feed intake vesicle, testicle, spleen and liver weights, and DES similarly reduced gain and feed efficiently in both castrate and intact male rats. Thus, there appears to be a basic difference in the response of rats to DES, compared to cattle and sheep, that does not depend on whether they are intact or castrate males.

Animals↗

PubMed1974