Biomedical subjects
Publications and source records attributed to G R Wilson.
A case of reconstruction of a large mandibular defect is presented, in which a 17 cm free vascularised fibular bone graft was first anastomosed to a radial fasciocutaneous flap in situ in the forearm, and then the combined flap was transferred and revascularised in the neck.
Two cases of migration of silastic rods into the forearm after the first stage of flexor tendon grafting are reported. A CT scan shows the rods well if they are not visible on a plain X-ray. Possible factors involved in distal detachment of the rods are the composition of the tendon spacer, method of distal fixation, method of proximal fixation and the time between the stages of reconstruction.
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BACKGROUND: There is a growing consensus that an improved research environment is needed for family medicine to continue to evolve. At the same time, there is relatively little discussion about practical ways to implement such an environment. Many believe that our efforts in this area lag far behind our accomplishments in education, training, and the practice of family medicine. PROGRAM DESCRIPTION: This manuscript discusses one community-based academic department's experience in formulating and implementing a research program. By slowly involving faculty in research and by instructing and encouraging residents, a research environment can be incorporated into a residency program's routine. The approach described in this manuscript is evolutionary and relies on committing resources to research while slowly involving faculty and residents in the process. PROGRAM EVALUATION: Measures of research output (funding, publishing in refereed journals, and presenting at professional conferences) suggest that the program has achieved some momentum in the area of research. Although relatively modest by the standards of some university-based programs, the program's achievements demonstrate that a community-based, university-affiliated program can initiate a viable research effort. CONCLUSIONS: Our experience has taught us that implementing a research program is a relatively lengthy process comprised of multiple components. First, individual projects typically consist of a process of funding, presenting, and publishing. Sharing research results with colleagues locally and at professional meetings is an especially important socialization component of research and scholarship. Second, it is important to use refereed and nonrefereed journals as outlets for scholarship, since the process of writing is itself important, especially for family physicians who lack formal research training. Finally, funding proposals and publications almost always require revision and resubmission, a process which contributes to creating and further refining the skills needed by successful researchers.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Management of large or recurrent basal cell carcinomas (BCCs) on the face can be difficult, especially where radiotherapy has been the primary treatment. Free tissue transfer using microvascular surgery permits wide excision margins ensuring clearance of the tumour without being compromised by concern over closure, since the free flap can be designed after the excision of the tumour and its size and composition can thus be custom made. Age alone should not be a contraindication to this major procedure.
Bone turnover and calcium homeostasis in man can only be modelled validly in Old World nonhuman primates. In order to interpret the models it is necessary to establish endocrine and biochemical parameters of bone mineral metabolism. This report is probably the first description of acute phase parathyroid responses to manipulations of blood ionised calcium, and of reference values for potentially interacting variables, in vervet monkeys. Plasma parathyroid hormone concentrations were measured in vervets under defined conditions, and ranges reported as normal for other nonhuman primates and man are summarised.
A case of failure of a free radial forearm flap is presented. It is surmised that this was due to venous thrombosis in the cephalic vein which showed evidence of recanalization of an old thrombus. The patient had received intravenous erythromycin some months previously.
Tissue expansion of the scarred chest following burns results in a poor breast mound shape with little projection or inframammary fold, since the expander, like normal developing breast tissue, is kept flat by the scarred skin envelope. We present a case that demonstrates that adequate projection of the breast and formation of an inframammary fold can be achieved by expansion if extensive release and skin grafting of contractures over the breast mound are performed after expansion. Maintained expansion will act as a stent reducing secondary contracture of the grafted-areas.
Each year from 1979 through 1983, 35 Angus bull calves were selected from a herd at the Eastern Ohio Resource Development Center to be individually fed in a 140-d postweaning performance test. From these 35 individually fed bulls, the three highest and three lowest for feed conversion (feed:gain) were selected and randomly mated to approximately 20 cows each. A different set of high vs low feed conversion sires was used each year. Four replicates (403 progeny) from high vs low sires were evaluated by sire groups for subsequent postweaning and carcass performance. Progeny were slaughtered when estimated by ultrasonic measurement to have 8.9 mm or more of subcutaneous fat at the conclusion of a 140-d postweaning performance test. Progeny with less than 8.9 mm of subcutaneous fat were fed for additional 28-d periods until they reached the required minimum. No differences were found between high and low feed conversion progeny for 140-d feed intake (P less than .30) although high feed conversion progeny gained .09 kg/d more weight (P less than .01) during the 140-d postweaning test. Differences tended to exist between high and low feed conversion progeny for unadjusted (P less than .15) and maintenance-adjusted (P less than .15) feed:gain ratios. Progeny of the high feed conversion group had greater subcutaneous fat (P less than .05) at the end of the 140-d postweaning test and when slaughtered (P less than .05), indicating a genetic difference for composition of BW gain between high- and low-sired progeny. However, no significant differences existed for any other carcass traits evaluated. Bulls had more desirable unadjusted (P less than .001) and maintenance-adjusted (P less than .001) feed:gain ratios than heifers with increased 140-d ADG (P less than .001) and pen feed intakes (P less than .001).
A single generation divergent selection study, replicated four times (1983, 1984, 1985, and 1986), was conducted to assess genetic differences between progeny of high and low feed conversion sires in Angus beef cattle and to determine correlated response for weight gain (ADG140), feed intake (AVFD140), and BW (OFFTSTWT) in a time- (140-d) and fat-constant (8.9 mm) period. Realized heritability estimates for unadjusted (feed/gain; FEFF140; .26) and adjusted feed conversion (adjusted as recommended by the BIF, 1986; ADJFDEFF; .46) were obtained. The difference in heritability estimates reflects variation accounted for by adjustment for BW differences, and thus maintenance requirements, of individual progeny. Phenotypic and "pseudo" realized genetic correlations of FEFF140 with ADG140, AVFD 140, and OFFTSTWT were -.33 and -.66, .49 and -.26, and .15 and -.41, respectively. Phenotypic and "pseudo" realized genetic correlations of ADJFDEFF with ADG140, AVFD140, OFFTSTWT, and FEFF140 were -.54 and -.59, .30 and -.23, .27 and -.36, and .97 and .49, respectively. Subcutaneous fat (as estimated by ultrasonic measurement; BF140) had phenotypic and "pseudo" realized genetic correlations with FEFF140 of -.33 and .66, respectively, and with ADJFDEFF of -.44 and -.58, respectively.
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Incubation of Bacillus thuringiensis HD-1 spores in the larval gut fluid of Manduca sexta (tobacco hornworm) resulted in increased viable counts, conversion to phase-dark spores, and a loss of absorbance in spore suspensions, indicative of spore germination. Heat-activated and untreated spores incubated in water did not exhibit these changes. Only when spores were heat activated and incubated in germinants L-alanine and adenosine did changes in the spores approximate those observed in gut fluid. These data suggest that M. sexta larval gut fluid induces the activation and germination of B. thuringiensis spores.
Spores and vegetative cells of Bacillus thuringiensis were more sensitive to UV light than were spores or cells of plasmid-cured B. thuringiensis strains or of the closely related Bacillus cereus. Introduction of B. thuringiensis plasmids into B. cereus by cell mating increased the UV sensitivity of the cells and spores. Protoxins encoded by one or more B. thuringiensis plasmids were not involved in spore sensitivity, since a B. thuringiensis strain conditional for protoxin accumulation was equally sensitive at the permissive and nonpermissive temperatures. In addition, introduction of either a cloned protoxin gene, the cloning vector, or another plasmid not containing a protoxin gene into a plasmid-cured strain of B. thuringiensis all increased the UV sensitivity of the spores. Although the variety of small, acid-soluble proteins was the same in the spores of all strains examined, the quantity of dipicolinic acid was about twice as high in the plasmid-containing strains, and this may account for the differences in UV sensitivity of the spores. The cells of some strains harboring only B. thuringiensis plasmids were much more sensitive than cells of any of the other strains, and the differences were much greater than observed with spores.
A prospective study of 208 children has shown that a significant number of them have an illness before suffering a thermal injury. The authors suggest that an unwell child is more likely to suffer a burn, and that first aid programmes should stress to parents to be even more careful when their child is unwell.