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Biomedical subjects

G Prasad

Publications and source records attributed to G Prasad.

At least 37 records · Page 2Linked to original sources
PubMed1989

The role of the thymus in the pathogenesis of hind-limb paralysis induced by ts1, a mutant of Moloney murine leukemia virus-TB.

Newborn homozygous BALB/c nude (nu/nu) mice, their heterozygous (+/nu) littermates, and normal BALB/c (+/+) mice were infected with ts1, a paralytogenic mutant of Moloney murine leukemia virus-TB (MoMuLV-TB). Our results indicate that while infection of +/nu and +/+ mice with ts1 results in severe pathological changes in the central nervous system (CNS) and paralysis, infection of nu/nu mice results in only mild to moderate pathology within the CNS and no paralysis. On the other hand, 50% of nude mice reconstituted with T cells when infected with ts1 developed paralysis and showed more pronounced degeneration of nervous tissue than nude mice infected with ts1 alone. These observations strongly suggest that the thymus, the functional T lymphocytes, or both play an important role in the ts1-induced neurologic disorders in infected mice.

Animals↗
PubMed1989

ts1, a mutant of Moloney murine leukemia virus-TB, causes both immunodeficiency and neurologic disorders in BALB/c mice.

BALB/c mice infected with ts1, a mutant of Moloney murine leukemia virus-TB, develop generalized body wasting, profound neurologic disorders, severe thymic atrophy and lymphopenia due to destruction of T lymphocytes and drastic immunodeficiency. ts1 was found not only able to infect T lymphocytes but also to impair their function. In addition, ts1 also infects and induces syncyntia formation in macrophages. The genetic determinant(s) responsible for ts1's ability to induce immunodeficiency has been localized to the env gene.

Animals↗
PubMed1985

Histochemical alterations in the duodenum of goats experimentally infected with Paramphistomum cervi.

Certain histochemical alterations in the different tunics of duodenum in kids were studied 20, 40, 60 and 80 days post-infection (DPI) with Paramphistomum cervi and the results compared with those of uninfected kids. There was a general reduction of polysaccharide complex substances and glycogen at 20 DPI. A marked decrease in polysaccharide complex substances and glycogen at 20 DPI. A marked decrease in polysaccharide complex substances and glycogen was especially discernible in the Brunner's gland and muscularis mucosa 20 DPI. Thereafter, these substances gradually increased and at 80 DPI this decrease was fully replenished. A slight reduction in mucin and protein content of the infected duodenal goblet cells was noticed at 20 DPI. It is suggested that juvenile P. cervi utilize host-tissue polysaccharide complex substances and glycogen for their growth and development during duodenal migration.

Animals↗
PubMed1976

Relapse in pulmonary tuberculosis.

Five hundred forty-three patients with bacteriologically confirmed pulmonary tuberculosis who successfully completed treatment were followed for 5 years to determine relapse rates and to see whether any factors could be said to predispose to relapse. Practically the entire treatment of these patients had been carried out in their homes. The cumulative relapse rate during a 5-year period was 11.60 per cent. Relapse rates were low during the first 2 years of follow-up. Of the various factors considered in the analysis, age, sex, initial extent of disease or cavitation, and presence of initial or emergent drug-resistant bacilli did not influence the relapse rate. Patients who achieved complete radiographic clearing at the time treatment was stopped and those who were regular in treatment had comparatively low relapse rates. Cured patients included in the study were asked to report at least once annually for a checkup, and immediately if they developed any symptoms suggestive of relapse. Only one fourth of the cases of relapse were detected during routine annual checkup; in the remaining cases, the patients attended ahead of the next due visit because of symptoms. This casts doubt on the utility of keeping cured patients under prolonged routine surveillance.

Adult↗