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Biomedical subjects

G Plewig

Publications and source records attributed to G Plewig.

At least 271 records · Page 15Linked to original sources
PubMed1982

Inhibition of sebaceous gland activity by spironolactone in Syrian hamster.

In the animal model of the Syrian hamster the antiandrogenic action of spironolactone on the sebaceous glands of the ventral side of the pinna was examined. Spironolactone reduces both labeling index and cross-sectional surface area of sebaceous glands significantly in a dose-dependent manner. Equally there was a significant decrease in serum testosterone levels in spironolactone treated animals. Our results seem to justify clinical studies with spironolactone in patients with hirsutism, seborrhea, and possibly acne vulgaris.

Animals↗
PubMed1982

Protection against UV-B by UV-A-induced tan.

Suntan is known to be protective against sunburn resulting from medium-wavelength ultraviolet radiation. Protection against UV-B by UV-A-induced pigmentation was studied by the evaluation of the erythema produced and by histologic alterations in the epidermis, including sunburn cell counts. Six subjects were deeply tanned with UV-A (mean cumulative dose, 700 joules/sq cm). The minimal erythemal dose to UV-B (300 +/- 5 nm) was established for each subject in normal skin and in UV-A-tanned areas. The UV-A tan provided measurable protection against UV-B-induced erythema. Following UV-B irradiation, 36 to 93 sunburn cells were counted per 10 mm of epidermal surface length in histologic sections of untanned skin as compared with four to seven sunburn cells in UV-A-tanned skin.

Adolescent↗
PubMed1982

[Growth of finger nails in psoriasis patients undergoing PUVA therapy].

In 78 persons aged 13-78 years with and without psoriasis the daily growth rate of fingernails was measured on three nails each of the right and left hand. Untreated patients with psoriasis had an increased growth rate (112.7 +/- 25.5 micrometers) compared to control subjects (102.5 +/- 18.5 micrometers) without psoriasis (p less than or equal to 0.001). In patients with psoriatic nail involvement the growth rate was significantly increased (113.9 +/- 29.2 micrometers). Photochemotherapy (PUVA) slowed down the nail growth rate in patients without nail involvement (92.8 +/- 21.8 micrometers) vs. untreated psoriatics without nail involvement (p less than or equal to 0.05). In psoriatics with nail involvement, PUVA therapy had no measurable effect on the growth rate of fingernails.

Adolescent↗
PubMed1982

[Photoallergic contact dermatitis by benzophenone containing sunscreening preparations].

The case of a 42-year-old woman with sunlight-provoked eczematous eruptions recurrent over several years is reported. Photopatch-testing with cosmetic products and sunscreen preparations used by the patient as well as the active ingredient of the sunscreen formulations revealed photosensitivity to the UV-blocking agent 2-hydroxy-4-methoxybenzophenone. The active wavelengths were shown to be in the UV-A range.

Adult↗
PubMed1982

[Tumor prevention in xeroderma pigmentosum using aromatic retinoid (Ro 10-9359)].

Aromatic retinoid Ro 10-9359 1 mg/kg body weight was given to an 11-year-old girl with xeroderma pigmentosum. Therapy resulted in disappearance of actinic keratoses and basal cell carcinomas. The occurrence of new tumors could be prevented in this patient while she participated in this preventive therapy for 7 months. The reduction of the aromatic retinoid to 0.4 mg/kg body weight every other day resulted in the reappearance of four basal cell carcinomas an one keratoacanthoma within 6 weeks.

Child↗
PubMed1982

[Photoallergic eczema caused by musk ambrette].

This study reports a photoallergic contact dermatitis to musk ambrette in two male patients. Musk ambrette is a widely used perfume ingredient, but it is also included in food and drugs. Both patients reacted in the long ultraviolet light (UV-A) to musk ambrette and to the after shave lotions containing musk ambrette. The histopathologic finding in the photopatch test site revealed acute spongiotic dermatitis.

Adult↗
PubMed1982

[PUVA therapy in persistent light reaction].

The diagnostic procedure in two patients suffering from persistent light reaction is described. In addition a modification of standard 8-methoxypsoralen-UVA (PUVA) schedule is presented which is necessary because of the extreme sensitivity to UV electromagnetic wave lengths in this photodermatosis. Both patients were able, for the first time in 8 years, to resume normal outdoor activities.

Aged↗
PubMed1981

Anti-inflammatory effects of 13-Cis-retinoic acid. An in vivo study.

Sixteen patients with care acne conglobata, acne fulminans, acme tetrade were treated orally with 13-cis-retinoic acid, 1-2 mg/kg body weight for 12 weeks. A maintenance dose of 0.5 mg/kg in ten cases and the use of no further medication in six other cases for an additional 12 weeks followed. A 40% potassium iodide ointment was used on the upper back under occlusive dressing conditions to induce an inflammatory reaction. Four inflammatory parameters were assessed in all subjects before and during oral treatment: erythema (0-2+), edema (0-2+), papules (numbers), and pustules (numbers). All patients showed excellent improvement. Additionally, the inflammatory reaction in all patch-tests was significantly reduced: erythema from 1.13 to 0.34 (P less than or equal to 0.01); edema from 1.06 to 0.25 (P less than or equal 0.0005); papules from 6.75 to 1.86 (P less than or equal to 0.01); and pustules from 10.44 to 1.56 (P less than or equal to 0.0025). We suggest that 13-cis-retinoic acid acts as a strong anti-inflammatory agent in addition to its known function as a sebostaticum.

Acne Vulgaris↗
PubMed1981

A new apparatus with high radiation energy between 320-460 nm: physical description and dermatological applications.

A new apparatus (UVASUN 5000) is presented with high radiation energy between 320-460 nm. The measurable energy below 320 nm was shown to be many orders of magnitude too low to produce erythema. The radiator is a specially developed source for high UV-A intensity, housing a quartz bulb with a mixture of argon, mercury and metal-halides. At a skin-target distance of 0.2 m the size of the irradiated area is 0.35 X 0.35 m, and the measured mean UV-A intensity is about 1400 W . m-2 (140 mW . cm-2). The UV-A energy in the range of 320-400 nm is about 84% of the total radiation energy. Effects of very high doses of UV-A on human skin were studied. Following single UV-A applications the minimal tanning dose UV-A (MTD) and the immediate pigment darkening (IPD) dose of UV-A were established. The calculated IPD threshold time was 1.8 min at 0.2 m. Repeated exposure to this UV-A delivering system yields long lasting dark brown skin pigmentation without any clinical or histological signs of "sunburn" (UV-B) damage, epidermal hyperplasia or thickening of the stratum corneum. The instrument was also successfully used for photo-patch testing and reproduction of skin lesions of polymorphous light eruption. Minimal therapeutic results were seen in the phototherapy of vitiligo and inflammatory acne.

Acne Vulgaris↗
PubMed1981

[Oral treatment of rosacea with 13-cis-retinoic acid].

Thirteen patients with severe rosacea (rosacea papulopustolosa, rosacea conglobata, and rhinophyma) were treated orally with 0.05, 0.5, or 1.0 mg/kg body weight 13-cis-retinoic acid (isotretinoin, Ro 4-3780) for 12-28 weeks. All patients had been treated previously with high doses of tetracyclines, metronidazole, or dermabrasion, etc., with no or only limited success. The therapeutic effect following 13-cis-retinoic acid was excellent. Inflammatory lesions regressed by 50% within 2 weeks, and by over 95% within 8 weeks. 13-cis-retinoic acid acts as a potent anti-inflammatory and sebum-suppressive agent. Besides papulopustules, nodules, and hemorrhagic abscesses, the inflammatory plaques and facial edema, but to a lesser extent teleangiectasias and the chronic conjunctivitis disappeared. The severe seborrhea disappeared. Long-lasting remission, similar to patients with severe acne being treated with 13-cis-retinoic acid, can be expected, as the first patients are in full remission for over 12 months at the time of writing. Exfoliative cheilitis occurred in every patient. Serum lipids increased only slightly. For female patients a reliable contraception is mandatory as teratogenicity cannot be excluded in this drug (similar to all retinoids).

Adult↗
PubMed1981

[Acanthoma fissuratum cutis].

Acanthoma fissuratum cutis is a common, however not widely recognized cutaneous lesion induced by minor, constant mechanical traumas. Lesions occur typically on the side of the nose or behind the ear, as most cases are caused by poorly-fitting spectacle-frames. Clinical features of the benign reactive tumors, which occasionally may be mistaken for basal cell epitheliomas, are presented.

Aged↗
PubMed1981

[Trachyonychia: 20-nail dystrophy].

Trachyonychia (20-nail dystrophy) is described in four patients with clinical, histological, and scanning electron microscopy techniques. Trachyonychia is a polyetiological symptom: psoriasis vulgaris, lichen planus, alopecia areata, atopic dermatitis, 20-nail dystrophy of childhood, and severe nail dystrophy can all lead to trachyonychia-like nail changes. Nail bed biopsies are necessary for proper diagnosis. In our patients, lichen planus, or psoriasis were excluded clinically and histologically. Spongiotic dermatitis of nail matrix and nail bed with column-like parakeratosis within the nail plate are found in trachyonychia due to alopecia areata, atopic dermatitis, and in its idiopathic form.

Adolescent↗
PubMed1980

[Oral treatment of severe forms of acne with 13-cis-retinoic acid. Clinical results (author's transl)].

A new, very effective method of treating severe forms of acne (papuplopustular, conglobate, fulminating and tetrad) is the oral administration of 13-cis-retinoic acid. The results described by Peck et al. (1979) in 14 patients are demonstrated in detail in 18 patients. In the initial therapy 1 to 2 mg/kg body weight were administered daily for 12 weeks without any other local or systemic treatment. In the second phase of the study half the patients continued treatment with 0.5 mg/kg body weight 13-cis-retinoic acid, the other half remaining without any further therapy. All inflammatory lesions healed after 12-16 weeks, sebum production was largely reduced. 13-cis-retinoic acid represents a remarkable turn in the treatment of most severe acne.

Acne Vulgaris↗