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Biomedical subjects

G Persson

Publications and source records attributed to G Persson.

At least 109 records · Page 6Linked to original sources
PubMed1982

Paracetamol plus supplementary doses of codeine. An analgesic study of repeated doses.

A double-blind, multicentre analgesic trial was carried out in patients suffering from pain after removal of an impacted lower wisdom tooth. 266 patients were evaluated after random allocation to treatment with paracetamol 500 mg, paracetamol 500 mg plus codeine 20 mg, paracetamol 500 mg plus codeine 30 mg, or paracetamol 500 mg plus codeine 40 mg. On the day of surgery the patients assessed their own pain intensity hourly on a visual analogue scale. The analysis of the results was carried out according to the method which considered repeated dose intake. A statiscally significant dose-response relationship was obtained between the supplementary doses of codeine and analgesic efficacy. In the comparison of side effects, their frequency increased with increasing amounts of codeine. In clinical practice codeine 30 mg appeared to be the optimal supplement for paracetamol 500 mg.

Acetaminophen↗
PubMed1982

Metabolic effects of digitalis.

In a study of two representative population samples of 70-year-olds, one of which was followed up at 75 years of age, digitalis treatment was associated with oestrogen-like metabolic effects, indicated by changes in the composition of the plasma phospholipid fraction. Digitalis treatment, at least at these ages, is related to metabolic effects even in patients lacking more obvious clinical signs such as gynaecomastia. The results suggest that digitalis treatment may have other oestrogenic effects, e.g. on the water and sodium balance, counteracting the cardiotropic effects of this drug.

Blood Pressure↗
PubMed1981

Loneliness in the Swedish aged.

Feelings of loneliness in relation to disease, handicaps, social network and social background were studied in a representative sample of 1,007 70-year-old people living in Göteborg, Sweden. The results showed that loneliness was a problem to 24% of the women and 12% of the men. The study allowed a detailed analysis of the association between feelings of loneliness and health, disabilities due to other than medical reasons, consumption of social and medical service, social contacts, cognitive functioning and personality traits. The most important factors related to the feeling of loneliness were the loss of spouse, depression of mood and lack of friends. The lonely had a negative self-assessment of health and consumed more out-patient care, social welfare help and sedatives. The higher consumption of medical service and/or social care was, however, not associated with a higher prevalence of definable somatic disease or handicaps.

Aged↗
PubMed1981

Five-year mortality in a 70-year-old urban population in relation to psychiatric diagnosis, personality, sexuality and early parental death.

In 1971-1972 a systematic, representative sample of 70-year-olds living in Gothenburg, Sweden, was studied. The study included a psychiatric examination, during which the subjects were questioned concerning important aspects of their life history, and mental symptoms during the previous month. Any mental signs observed were recorded. Symptoms and signs were rated on rating scales, and summed up in diagnoses. The subjects also filled in three different personality inventories. The examination was performed in 166 men and 226 women. In 1976-1977 we ascertained from parish records which subjects had died before reaching the age of 75. Thirty-two men and 23 women had died. Associations between the psychiatric variables and mortality were studied. There was a positive association in men between mortality and organic psycho-syndromes. There was a positive, but nonsignificant association with indications of previous alcohol abuse. There was no association with anxiety, depressive and obsessive compulsive neuroses or personality deviations and few associations with personality dimensions and psychogenic needs. There was a positive association in married men between mortality and early cessation of sexual intercourse. There was also a positive association in men between mortality and loss of parents by death before the age of 16.

Aged↗
PubMed1980

Fat cell number, resting metabolic rate, mean heart rate, and insulin elevation while seeing and smelling food as predictors of slimming.

The explanatory value of total fat cell number, resting metabolic rate, mean heart rate during sleep, and peripheral insulin while seeing and smelling food were examined in relation to weight reduction in 19 obese women on a 1100-kcal/day diet. The insulin response while seeing and smelling food was expressed as the insulin area (mU x min x 1(-1)) over the baseline level. Food was presented in front of the patient for 5 min. Insulin was determined in short intervals 20 min before and 20 min after start of food presentation. Fat cell number, resting metabolic rate, and mean heart rate during sleep were determined with standard techniques. All patients went through a period of weight loss, a plateau phase, and a period of weight regain. Body weight, fat cell number, resting metabolic rate, and/or heart rate correlated significantly with degree and rate of weight loss, duration of plateau phase, and rate of regain. In multiple regression analysis fat cell number and resting metabolic rate explained 81% of the variance for weight loss, 66% for rate of regain, and 29% for duration. For duration, only fat cell number contributed significantly. The variance of rate of weight loss was explained up to 49% by metabolic rate and insulin response while seeing and smelling food. The possibility of predicting weight reduction to a certain target weight is of great practical importance since the patients can obtain a realistic goal for their efforts to reduce body weight. Hopefully systematic investigations of factors associated with the inability of obese subjects to maintain weight reduction will improve treatment in the future.

Adipose Tissue↗
PubMed1980

Life event ratings in relation to sex and marital status in a 70-year-old urban population.

A subsample of 151 subjects from the population study "70-year-olds in Gothenburg" were given a questionnaire for life event ratings to be returned by mail. The 24 life events to be rated were events that are fairly common in advanced age. The ratings were in most cases similar for men and women. Some events, pertaining to children, were given more weight by the women, while "loss of sexual ability or interest" was given greater weight by the men. Single women gave less weight to events that could not happen to them. It thus seems that events that cannot happen to yourself are seen as less important than events that can. Married women who had never worked outside their homes attributed more weight to some events than married women who had worked outside their homes. Men and women attributed similar weight to the event "becoming mentally ill", which event was given more weight than the event "becoming somatically ill". The results do not explain the higher incidence of neurosis among the women in the population.

Aged↗
PubMed1980

Prevalence of mental disorders in a 70-year-old urban population.

The prevelance of mental diseases and abnormalities in a representative, systematic sample of 70-year-olds in Gothenburg, Sweden, is presented. Out of 460 selected subjects, 392 (85.2%) took part and the responders and non-responders were similar in several respects. A case was defined by cut-off points on symptom and/or sign rating scales and diagnoses were defined operationally but as closely as possible to the ICD-classification. The total psychiatric morbidity, excluding personality deviations, was 16.9% in men and 26.1% in women, and excluding also mild neuroses 12.7% in men and 15.5% in women. The prevalence of psychoses was 3.0% in men and 3.5% in women, of neuroses of moderate-severe degree 6.6% in men and 11.5% in women, of neuroses of mild degree 4.2% in men and 10.6% in women, of alcoholism 3.0% in men and 0.0% in women and of oligophrenia 0.0% in men and 0.4% in women. The prevalence of demential syndromes of a psychotic degree was 2.4% in men and 1.3% in women, of a neurotic degree 4.2% in men and 1.8% in women and the total prevalence of demential syndromes was thus 6.6% in men and 3.1% in women. Indications of previous alcohol problems and no or a low current consumption of alcohol were noted among 18.1% of the men.

Aged↗