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Biomedical subjects

G Pappalardo

Publications and source records attributed to G Pappalardo.

At least 109 records · Page 6Linked to original sources
PubMed1977

[Synthesis of 2,3-diazaphenothiazine. XI. 2- and 3-arylderivatives of 10-methyl-2,3-dihydropyridazine /4,5-b/ / 1,4/ benzothiazin-1,4(10H)-dione].

The synthesis of 3-phenyl-10-methyl-2,3-dihydropyridazine[4,5-b] [1,4]benzothiazin-1,4(10H)-dione (I) and the 2 phenyl siomer-(II) is described. The compounds were prepared by the reaction of 2-methylaminothiophenol with 1,2-dihydro-20phenyl-4,5-dibromopyridazin-3,6-dione in an alkaline aqueous/alcoholic medium. The structure of the two isomers was demonstrated by transformation of (I) into 3-phenyl-10-methyl-3H-pyridazino[4,5-b] [1,4]benzothiazin-4(10H)-one (IV) reported in the literature.

Cyclization↗
PubMed1977

[Synthesis and antimitotic activity of 3- and 5-halogen substituted bis-(2-aminophenyl)disulfides and corresponding N-alkyl derivatives].

In continuation of previus research on the antimitotic activity of aryldisulfides, the Authors have synthesised 3- and 5-chloro or fluoro substituted bis-(2-aminophenyl)disulfides and some of their 2-N-alkyl derivatives. These compounds were synthesised in order to submit them to biological testing to find any activity caused by halogen substituents on the benzene ring.

Chemical Phenomena↗
PubMed1977

[Synthesis of 2,3-diazaphenothiazine. XII. Dialkylaminoalkylic derivatives of 2-phenyl and 3-phenyl-10-methyl-2,3-dihydropyridazino/4,5-b/ /1,4/benzothiazin-1,4 (10 H)-dione].

The alkylation with methyl iodide and methyl sulfate of 2-phenyl-10-methyl-2,3-dihydropyridazino [4,5-b] [1,4]benzothiazin-1,4(10H)-dione (A) and the corresponding 3-phenyl substituted isomer (B) has been studied. Some derivatives of (A) and (B) substituted at the O atom with dialkyaminoalkyl groups are described; these have been subjected to pharmacological testing.

Alkylation↗
PubMed1977

[Synthesis of dithienyldisulfides].

The synthesis of 2,2'-dithienyldisulfides, variously substituted in position 3 and/or 5 with --NO2, --NHCOCH3, --SO2NH2 groups and of 2,2'-dinitro-3,3'-dithienyldisulfide is described. The antitumor activity of these compounds was tested.

Antineoplastic Agents↗
PubMed1977

[Synthesis of 2,3-diazaphenothiazines. XIII. Dialkylaminoalkylic derivatives of 7-acetylamino-2H-pyridazino(4,5-b) (1,4)benzothiazin-1 (1OH)one and of the isomer of 7-acetylamino-3H-pyridazino(4,5-b) (1,4)benzothiazin-4 (1OH)-one].

Some derivatives of 7-acetylamino-2H-pyridazino [4,5-b] [1,4] benzothiazin-1 (1OH)-one (VI a...d) and of 7-acetylamino-3H-pyridazino [4,5-b] [1,4]benzothiazin-4 (1OH)-one (X a...d) substituted in the 2 and 3 positions with dialkylaminoalkyl groups are described. The compounds were subjected to pharmacological screening.

Alkylation↗