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Biomedical subjects

G Nyerges

Publications and source records attributed to G Nyerges.

At least 55 records · Page 3Linked to original sources
PubMed1978

Progressive vaccinia: immunological aspects and transfer factor therapy.

Progressive vaccinia is a rare and serious complication of smallpox vaccination. Depressed immune function can generally be found as an underlying disorder; thus adequate immuno-correction may be expected to be therapeutically effective. Humoral and cell-mediated immunity was repeatedly examined in one case throughout the course of the disease. Results indicated partial deficiency of cell-mediated immunity. No therapeutic effect was achieved by using human antivaccinia immunoglobulin and N-methylisatin beta-thiosemicarbazone. Transfer factor therapy was also attempted. Treatment with a non-specific transfer factor preparation was followed by a transitory clinical improvement. A specific transfer factor preparation given during the last month of life, however, had no therapeutic effect. The patient died on the 145th day after vaccination. Autopsy findings pointed to combined immune deficiency.

Humans↗
PubMed1978

Mucocutaneous lymph node syndrome: three cases observed in Hungary.

Three patients are reported whose symptoms were very similar to those described in mucocutaneous lymph nodes syndrome, a disease prevalent in Japan. In one case the disease was complicated by otomastoiditis which prolonged the course and reactivated the symptoms. In the other two cases recovery was uneventful. No epidemiological relation could be demonstrated among the cases. Prednisolone was administered to two patients with immediate antifebrile effect.

Child↗
PubMed1977

Mumps meningitis: electroencephalography and leukocyte migration inhibition by basic myelin protein.

In 20 patients with mumps meningitis, electroencephalography and leukocyte migration inhibition tests with basic myelin protein were carried out. Fourteen patients had mild or moderate EEG abnormalities indicative of encephalitis as well. Cellular reactivity to basic myelin protein was found in 4 cases only. The observations support the concept that mumps meningoencephalitis is a consequence of a direct viral impact onto the nervous tissue, i.e. no neuroallergic mechanisms are involved.

Cell Migration Inhibition↗
PubMed1977

The encephalitogenicity of the Hempt vaccine.

The encephalitogenic property of rabies vaccines of brain tissue origin (Hempt vaccine produced in different institutes, Semple vaccine, International Standard of Rabies Vaccine) was studied in animal experiments. Guinea pigs inoculated with the vaccines in complete Freund adjuvant were observed for clinical signs and histopathological changes characteristic of experimental allergic encephalomyelitis. Normal sheep brain suspension was used as control. The minimal encephalitogenic dose of the Hempt vaccine was found about 3,500 times more than that of the control material. Hempt vaccine proved much less reactogenic than the International Standard of Rabies Vaccine and the Semple vaccine. Subsequent lots of Hempt vaccine were slightly different in respect of their encephalitogenic activity.

Animals↗
PubMed1976

Leukocyte migration inhibition by a specific antigen in human typhoid fever.

Cellular reactivity to heat-killed Salmonella typhi antigen was investigated by the leukocyte migration inhibition (LMI) method in 33 S. typhi infected patients and in 32 control persons. In the typhoid group a statistically significant LMI was observed as compared to the members of the control group. A correlation was found between the level of the cellular sensitivity and the time elapsed between onset of the disease and performance of the test. Previous typhoid vaccination had no influence on the LMI. No correlation was found between the agglutinin titres and the sensitivity demonstrated by the LMI test. The value of the method in studies of cellular immunity in typhoid fever is discussed.

Agglutinins↗
PubMed1976

Non-specific antimicrobial cellular resistance in sensitized guinea pigs.

Specific delayed-type hypersensitivity was induced in guinea pigs with bovine albumin + complete Freund adjuvant, bovine gamma globulin + complete Freund adjuvant and BCG vaccine. The animals were subsequently tested for nonspecific antimicrobial resistance. Sensitized and control groups were challenged intraperitoneally with Listeria monocytogenes 2 hr after reinjection with the sensitizing antigen. The listeria content of the spleens was determined 1 or 5 days after the infection. The number of organisms recovered from the spleen one day after infection was significantly less in guinea pigs sensitized with bovine gamma globulin and BCG than in the control group; after 5 days no such difference was recorded. There was no difference between the bovine albumin sensitized and the control group 1 day after infection, while on the 5th postinfection day listeria counts were higher in the sensitized than in the control animals.

Animals↗
PubMed1975

Leukocyte migration inhibition by a specific antigen in human brucellosis.

Leukocyte migration inhibition /LMI/ tests were carried out in 19 patients with Brucella abortus bovis infection and in 18 healthy control subjects using killed Brucella abortus bovis as antigen. In the brucellosis group a statistically significant LMI was observed, as compared to the members of the control group. Using the same antigen, a fairly good correlation was found between the local skin reaction and the results of the LMI test in the subacute or chronic stage of the disease. However, the results of the LMI test showed no correlation with either the clinical activity of the disease or the serological results and the general reactions elicited by the skin test. Since LMI and skin tests give nearly identical results in subacute or chronic brucellosis, it is suggested that the LMI test may be used as a safe test instead of the skin test.

Antigens, Bacterial↗
PubMed1975

Leukocyte migration inhibition by a brain tissue antigen and electroencephalography in uncomplicated measles.

In 11 patients with uncomplicated measles and in 10 control patients with acute enteritis, electroencephalography and leukocyte migration inhibition test using basic myelin protein as antigen were carried out. There were no EEG abnormalities and no migration inhibition in the control group. Leukocyte migration inhibition was observed in 9 measles patients; among these 5 had slight or moderate EEG abnormalities. It is suggested that EEG abnormalities have the same pathological background in uncomplicated measles as in measles encephalitis.

Antibody Formation↗