Search PubMed⌕ Search

Biomedical subjects

G Nyerges

Publications and source records attributed to G Nyerges.

At least 37 records · Page 2Linked to original sources
PubMed1983

The potency testing of diphtheria and tetanus toxoids as determined by the induction of antibody in mice.

An antibody induction (AI) assay in mice has been developed for the potency testing of diphtheria and tetanus toxoids. A diphtheria-pertussis-tetanus served as a reference preparation so that both toxoids could be tested within the same experiment. Results have been compared with those obtained by the conventional lethal challenge tests in guinea pigs (diphtheria) and mice (tetanus). The potency values obtained in the AI tests reflected the differences in the toxoid content of the preparations. Being an economical method, the AI test can be recommended for the potency control of DPT vaccines subject to confirmation of the authors' observations by others.

Animals↗
PubMed1983

The diagnostic value of varicella-zoster virus (VZV)-specific antibodies in the early phase of varicella in immunocompromized children.

Varicella-zoster virus (VZV)-specific antibodies were tested by indirect membrane immunofluorescent technique in sera of 32 immunocompromized children during the first week after onset of varicella. VZV-specific IgM antibodies were found in sera of all but four patients. Three of the four IgM negative patients were followed up, and it was demonstrated that all of them gave a retarded antibody response. They had severe leukopenia and had several relapses of their VZV-infection. The results indicate (a) that the demonstration of VZV-specific IgM antibodies is of diagnostic value even in atypical varicella of immunocompromized patients; and (b) that in cases with retarded antibody response relapses can be expected.

Adolescent↗
PubMed1983

Cell-mediated immunoreactivity in acute human trichinellosis.

Twenty patients were examined for studying specific cellular immunoreactivity in human trichinellosis. Serial leukocyte migration inhibition tests were carried out using trichinella larvae as antigen. The mean migration indices of the patients differed significantly from that of the healthy controls. As the most distinct immunoreactivity was found during the acute phase of the disease, it is suggested that the cellular immune response may be of some importance in the development of symptoms. It is, however, stressed that the diagnostic value of the LMI method is less than that of the serological tests in individual cases.

Acute Disease↗
PubMed1983

[Clinical experiences with intravenous immunoglobulin therapy of infectious diseases in infancy and childhood].

In 26 infants with severe sepsis antibacterial therapy was supplemented by the intravenous administration of immunoglobulins (Endobulin, Immuno AG, Vienna). Such therapy was indicated in 6 patients by the appearance of granulocytopenia during the treatment of their underlying disease, in 14 children by their very young age which was less than 2 years, and in 6 children by the failure of antibacterial therapy to produce the desired effect. Depending on the clinical picture of sepsis different organ manifestations were seen, purulent meningitis (10 cases) and pneumonia (9 cases) being the most frequent. In 24 patients immunoglobulin therapy led to complete recovery. In all 7 cases of purulent meningitis, the simultaneous administration of antibiotics and immunoglobulins was effective.

Agranulocytosis↗
PubMed1982

Leukocyte migration inhibition (LMI) by a specific antigen in human toxoplasmosis.

The diagnostic value of the leukocyte migration inhibition test was examined by comparing it to other specific laboratory methods i.e. complement fixation, indirect haemagglutination and skin test in 10 patients with acquired lymphoglandular toxoplasmosis. In the acute phase the serological tests gave more reliable results than did the LMI test. In subacute and chronic cases, however, there was a good correlation between dermal reactivity and LMI test. LMI is believed to represent a specific test for the detection of cellular hypersensitivity in human toxoplasmosis and so it can be used as a non-invasive method instead of dermal tests.

Antibodies↗
PubMed1982

Sensitizing activity to egg protein of an A1PO4-adjuvant full-virus influenza vaccine.

The sensitizing activity to egg protein of an A1PO4-adjuvant purified and concentrated influenza-A vaccine was examined in animal experiments and in man. Intravenous injection of ovalbumin caused anaphylactic symptoms and/or fatal anaphylactic shock in prevaccinated guinea-pigs. Ovalbumin-specific antibodies detectable by the passive haemagglutination reaction (PHA) appeared in the blood serum of the vaccinated animals. Model experiments with purified ovalbumin suggested that 1 human dose of the vaccine contained egg protein in the range from 0.1 to 1 ng, and that the antigenic effect of the vaccine grew to more than 10(3)-fold by its adsorption to A1PO4 gel. Adults who in previous years had been immunized with similarly prepared influenza vaccine several times responded with mild reactions; symptoms suggestive of hyperergy did not occur, irrespective of the vaccination history. In the prevaccination serum sample of some vaccines, ovalbumin-specific PHA antibodies were found up to titres independent of the number of the previous immunizations. The concentration of the ovalbumin-specific antibodies of the IgE class was by several orders of magnitude lower in the postvaccination samples than in the serum of some patients hypersensitive to egg protein.

Adjuvants, Immunologic↗
PubMed1981

Reliability of the rabbit pyrogen test and of the limulus test in predicting the pyrogenicity of vaccines in man.

Commercial vaccines including bacterial as well as live and inactivated viral vaccines were examined in the rabbit pyrogen test and in the limulus test. The laboratory results were compared with the reactivity in humans. A fairly good correlation was found between the temperature rise in rabbits and the frequency of febrile reaction in the vaccinees. Two rabies vaccines and a tick-borne encephalitis virus vaccine, each pyrogenic both in rabbit and in man. were negative in the limulus test. The pyrogenicity of these vaccines is attributed to the vaccine virus itself.

Bacterial Vaccines↗
PubMed1979

Development of specific cellular immunoreactivity in typhoid fever.

Development of cellular immunoreactivity to Salmonella typhi and Salmonella paratyphi-A was studied by the leukocyte migration inhibition test in 9 patients with typhoid fever and in 2 patients with paratyphoid fever. Cellular reactivity could be demonstrated from the first days of the disease in all the subjects. The most pronounced migration inhibition was observed during the febrile period. It is suggested that specific cellular reactivity may play a pathogenetic role in typhoid fever.

Adult↗