Biomedical subjects
G Naumann
Publications and source records attributed to G Naumann.
[A method for demonstrating antibody-coated bacteria in urine (author's transl)].
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Antibody-coating of bacteria in the urine in relation to various immunologic indexes.
Little is known about the immunologic aspects of antibody coating, though the test for determining antibody-coated bacteria in urine has been examined for its diagnostic uses by many authors after its inauguration in 1974. In adults with chronic pyelonephritis with and without antibody-coated bacteria in the urine, we tested whether bacterial coating is correlated with the homologous O-antibody titre in the urine. We also determined Ig levels in urine and serum, as well as homologous O-antibody titres in serum. By means of indirect immunofluorescence technique, we were able to show homologous O-antibodies in the urine of all patients with and without antibody-coated bacteria. IgG and IgA levels in urine were mostly raised, as were often the O-antibody titres in the serum. There were no significant differences in the immunologic parameters within the patient groups with or without antibody-coating. The presence of homologous O-antibodies in urine does not therefore necessarily lead to coating of the bacteria.
[Antibody-binding bacteria in the urine in infantile pyelonephritis].
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[Efficacy of a model surveillance system for juvenile urinary infections in the Sternberg district].
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[Typing of E. coli rough strains with phages (author's transl)].
Two phage-sets were used for the typing of 408 E. coli rough strains isolated from patients with urinary tract infections, Using the 13 phages A to M (11), we were able to type 225 (55.1 per cent) strains. 143 (35 per cent) of these strains were found to have K antigen, 84 different phage patterns could be recognized. Phage patterns GHK, M, F, and AM were the most common ones found. The application of the typical rough phages Br10, C21, 6SR, FP1, T4, and the Felix O (FO) phage led to the successful typing of 143 (35 per cent) strains, 80 of which (19.6 per cent) had a K antigen. About 70 per cent of the strains typable were found to belong to phage patterns which were represented by single phages, 24 different R phage patterns were observed. Considering both phage-sets the total typability amounted to 67 per cent. It is concluded that phage typing may be useful for the typing of E. coli rough strains in urinary tract infections in order to distinguish between relapse and reinfection.
[Microbiological aspects of human pyelonephritis].
Issuing from the adhesive ability of bacteria to human mucous membranes the phenomenon of the adhesion of E. coli to uroepithelial cells is analysed in detail. Fimbrias and colonisation factors might be of importance. In own experiments the first clues concerning the numberous appearance of these adhesive factors could be got. In further investigations the author adopts a definite attitude to the problems of the rough forms of E. coli as the pathogenic agent of a pyelonephritis of man. It is to be assumed that by the occurrence of certain factors of virulence rough forms possess importance as causal agents of pyelonephritis.
[Escherichia coli o serotyping in different patient groups with urinary tract infections (author's transl)].
Using 44 anti-O sera 789 Escherichia coli strains isolated from the urine of patients with urinary tract infections were typed. Of the 119 E. coli strains from the urine of children, 49.6% were O-typable; only 3.4% were rough strains. Of 357 strains from pregnant women, 47% were O-typable; 12.1% were rough strains. The largest proportion of O-typable E. coli strains was found among 314 strains isolated from adults with recurrent urinary tract infections (55.4% of the 314 strains); 8% were rough strains. The higher proportion of E. coli rough strains in adults, including pregnant women, indicate that once a pyelonephritis process has been established by virulent smooth strains in childhood, it can be sustained by rough strains at a later stage. Certain O serotypes were found to occur with a variable frequency in the individual patient groups. Enteropathogenic E. coli strains were seldom found in any of the three groups.
[Escherichia coli O Serotyping in different patients groups with urinary tract infections (author's transl)].
Using 44 anti-O sera 789 Escherichia coli strains isolated from the urine of patients with urinary tract infections were typed. Of the 199 E. coli strains from the urine of children. 49.6% were O-typable; only 3.4% were rough strains. Of 357 strains from pregnant women, 47% were O-typable; 12.1% were rough strains. The largest proportion of O-typable E. coli strains was found among 314 strains isolated from adults with recurrent urinary tract infections (55.4% of the 314 strains); 8% were rough strains. The higher proportion of E. coli rough strains in adults, including pregnant women, indicate that once a pyelonephritis process has been established by virulent smooth strains in childhood, it can be sustained by rough strains at a later stage. Certain O serotypes were found to occur with a variable frequency in the individual patient groups. Enteropathogenic E. coli strains were seldom found in any of the three groups.
[K antigen, colonization factor antigen, dulcitol fermentation, and hemolysin production in E. coli rough strains isolated from urine specimens (author's transl)].
E. coli rough strains (as determined by spontaneous agglutination of in boiled saline suspension) isolated in significant amounts (>10(5)/ml) from from patients with urinary tract infections were investigated for some factors possibly related to virulence. The frequencies of capsular antigen, colonization factor antigen (CFA I), dulcitol fermentation, and hemolysin production are summarized in table 1. 270 (66.2%) out of 408 strains were found to be encapsulated as determined by the inagglutinability of the living strains in saline. 180 (44.1%) strains were able to ferment dulcitol, and evidence for hemolysin production could be demonstrated in 146 (35.8%) strains. The CFA I (demonstrated by a mannose resistant hemagglutination of human red blood cells) was detected in 62 (15.2%) of the E. coli rough strains tested. The frequency of single properties in the presence or absence of capsular antigen is shown in table 2 demonstrating no significant differences in both groups. The most frequent single factor was found to be the capsular antigen with 22.1%, followed by the double combination capsular antigen/dulcitol fermentation (16.7%), dulcitol fermentation alone (10%), and capsular antigen/hemolysin production (9.8%). There were only 5 strains possessing all four factors tested. On the other hand we found 35 (8.6%) rough strains with none of the properties. Some aspects of virulence of E. coli rough strains are discussed.
[Hygienic bacteriological environmental tests in a recently opened urological clinic--monitoring the surgical department and the kidney transplantation center].
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[Problems of detecting inhibitors in urine].
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[Efficacy of systemic rehabilitation in patients with myocardial infarct--a 4 years' study].
Form and results of the rehabilitation of patients with myocardial infarction during and after clinical treatment are described in a 4-year-study. According to the form a system rehabilitation is concerned. It comprises a continuous course of early mobilisation during clinical treatment, immediately following group exercise treatment after clinical treatment, then a sanatory cure and a continuing life-long group training. The results are an ergometrically objectified increase of physical function which is larger than in an untrained patient and a decrease of the factor of risk, on the basis of which a high degree of occupational and social rehabilitation is gained.
[Microbiological studies in maxillofacial inflammations].
297 materials from 446 patients with pyogenic infections were microbiologically evaluated. It was stated that Staphylococcus aureus is still the main causative organism (in spite of a downward tendency) and that its penicillin resistance is again increasing. The other gram-positive cocci occurred less frequently as pure cultures and more often as mixed cultures. The gram-negative germs increased with the increase in sensitivity to chemotherapeutical agents. 159 materials remained sterile. It must be assumed that this is in part attributable to anaerobes so far not determined. These results permit to draw the following practice-relevant conclusions: The territorial resistogram determines the use of chemotherapeutical agents; and it seems advisable not to employ penicillin in outpatient practice. Where the use of an antibiotic is indicated, treatment with oxytetracycline or gentamycin should be started.
[Comparison of the frequency of the O-antigens of E. coli strains isolated from urine in Rostock and Moscow].
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[On the 75th birthday of Dr. Franz Köhler].
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[Problems of serological diagnosis of chronic pyelonephritis (author's transl)].
Using the passive hemagglutination test, 588 sera of patients with chronic pyelonephritis and 163 sera of pregnant women with persistent bacteriuria were investigated for the presence of antibodies aginst the enterobacterial common antigen (ECA). 10.2 percent of titers in the pyelonephritis group and 6.1 percent of titers of the pregnant women showed values higher than 1:16. The results were compared to a group of blood donors where 0.9 percent of the sera had pathological titers. The demonstration of ECA antibodies does not seem to be suitable for the diagnosis of urinary tract infections.
[Common antigen for serological detection of urinary tract infections during pregnancy (author's transl)].
All urinary tract infections cannot be safely detected by bacterial urine testing during pregnancy. Therefore, the question was studied whether detection of antibody to the "enterobacterial common antigen" (ECA) might be important to screening of pregnant women for urinary tract infections. Tests were applied to 202 sera obtained from 42 pregnant women with urinary tract infection, with pathological titres having been recorded from 21.8 per cent.--Detection of antibody to ECA, consequently, is not believed to be helpful in improving diagnosis of urinary tract infections during pregnancy.