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Biomedical subjects

G Moser

Publications and source records attributed to G Moser.

At least 109 records · Page 6Linked to original sources
PubMed1989

[The significance of psychosocial complaints in the initial interview--a study of unselected patients of an internal medicine/polyclinic university ambulatory service].

In clinical practice one is repeatedly confronted with patients, who report psycho-social problems during the first interview. In this study 128 patients have been examined in the outpatient clinic at the Department of Medicine 1 of the University Hospital in Vienna. The most important issue investigated was to clarify whether or not the psycho-social complaints expressed at the initial interview could be correlated with either functional disorders or somatic disease. Further we tried to determine whether or not the complaints influenced the course of the disease and gave any indication for the presence of a depressive disorder or complicated a somatic disorder by additional psychosomatic complaints. Our results indicate that the expression of psycho-social problems indeed correlates with stronger psychosomatically conditioned body dysfunctions, but do not sufficiently explain whether or not functional disease can be expected. However, the reported psycho-social problems result in a stronger inclination towards depressive mood and lead the patient to his/her own explanation how the illness has developed. Both facts are of importance for the patient-physician relationship and constitute an integral part of the (non-)compliance.

Adolescent↗
PubMed1988

Lack of association between HLA antigens and anorexia nervosa.

Studies of the human leukocyte antigen (HLA) system were performed in 37 patients with anorexia nervosa to confirm an alleged association with HLA-B16 and haplotype HLA-A26,B38. No correlation between anorexia nervosa and HLA, including HLA-DR, could be found.

Adult↗
PubMed1987

Distinction between the G0 and the late G1 phase of rat cells in vivo and in vitro with the nuclear QDH-fluorescence pattern.

The quinacrine dihydrochloride (QDH) staining and the [3H]thymidine incorporation patterns were simultaneously analyzed in nuclei of rat cells from a proliferating (granulation tissue) and a nonproliferating tissue (liver). Nuclei from freshly isolated and cultured cells of the rapidly proliferating subcutaneous granulation tissue showed a cell cycle-related pattern similar to that previously described with growing fibroblast-like cells in vitro. Nuclei of liver cells in smears from biopsies and in histological sections showed a fluorescence pattern similar to that of serum-deprived arrested G0 cells from established cell lines. Treatment of primary cultured rat hepatocytes with phenobarbital altered their degree of chromatin condensation similar to that seen after treatment of rats in vivo. The data indicate that the QDH staining pattern is an early marker, suitable for detecting the cell cycle-promoting activity of chemicals (e.g., of tumor promoters) in nonproliferating cells from various tissues in vivo and in vitro.

Animals↗
PubMed1986

Accessory cells in immune suppression. III. Evidence for two distinct accessory cell-dependent mechanisms of T lymphocyte-mediated suppression.

Suppression of antibody secretion by the 2,4,6-trinitrophenol (TNP)-binding BALB/c myeloma, MOPC 315, by idiotype- and hapten-reactive suppressor T cells is mediated by secreted factors (TsF) and requires the presence of accessory cells (AC). Idiotype-specific TsF functions only in the presence of Ia+ AC and is completely idiotype specific. Moreover, no suppression is observed when myeloma targets and AC are separated by cell-impermeable membranes, indicating that the role of AC may be to bind, focus, and/or present TsF to the myeloma cells. In contrast, TNP-specific TsF inhibits myeloma function in the presence of TNP-protein and activated macrophages that are not Ia+. This form of suppression is nonspecific at the effector stage; i.e., anti-TNP TsF inhibits a non-TNP binding cell line, TEPC 15, as long as TNP-protein and activated macrophages are present. Moreover, suppression occurs even when myeloma targets and AC are separated by cell-impermeable membranes. These results are consistent with the view that hapten-reactive TsF binds to antigen on the surface of macrophages and induces these cells to secrete nonspecific immunosuppressive molecules. Thus, different types of AC may play fundamentally different roles in TsF-mediated suppression; they may either bind and present TsF to targets (as in the case of idiotype-specific TsF) or secrete nonspecific immunosuppressants as a consequence of a TsF-antigen interaction (hapten-specific TsF). Autonomous, suppressible targets provide valuable experimental systems for analyzing the cellular interactions in T cell-mediated suppression.

Animals↗
PubMed1985

Blood and urinary magnesium, zinc, calcium, free fatty acids, and catecholamines in type A and type B subjects.

Twenty type A male students were compared to nineteen type B male students (all in apparently good health), before and after exposure to combined stress (noise and task). Before stress, red blood cell (RBC) Zn concentration is higher (P less than .05) and Zn excretion lower (P less than .05) in type A than in type B people. After stress, type A subjects exhibit changes that are larger and more significant than those of type B individuals. After stress, the type A group shows an important increase of urinary catecholamines (P = 2.10(-5), serum free fatty acids, and urinary Zn (P = .001); a slight increase in plasma magnesium (P less than .05); and a small but significant decrease in RBC Mg (P less than .02). These results suggest that type A subjects are more sensitive to stress than are type B people and more readily lose their intracellular Mg, the rise in plasma Mg being a transient one, probably consecutive to the cellular loss. The present observations are in good agreement with published data: ie, the psychological characteristics of type A personalities; their greater susceptibility to ischemic heart disease, which has been associated with Mg deficiency; the possible role of hypomagnesemia in the pathogenesis of hypertension and coronary vasospasm; and the high RBC Zn levels found in hypertensive patients.

Adult↗
PubMed1985

Accessory cells in immune suppression. II. Evidence for presentation of idiotype-specific suppressor factors to B cell targets by I-A+ accessory cells.

The functional suppression of two BALB/c myelomas, MOPC315 and MOPC460, by idiotype-specific suppressor T cells is mediated by secreted factors (TsF). Idiotype-specific TsF only functions in the presence of accessory cells (AC) that can be low density splenocytes or cells of BALB/c B lymphoma A20-2J. Such AC are I-A+ but do not have to be histocompatible with the myeloma targets or the source of TsF. A20-2J cells incubated with soluble idiotype and TsF also are capable of suppressing the relevant myeloma target. The effect of TsF-pulsed A20-2J cells is idiotype specific, and these cells do not secrete immunosuppressive mediators. Finally, TsF-pulsed A20-2J cells suppress myeloma targets when the two are cultured on the same side of a cell-impermeable membrane but not when they are separated by the membrane. These results indicate that I-A+ cells are capable of concentrating and/or presenting TsF to suppressible targets, and they demonstrate a novel role for Ia-bearing cells in immune regulation.

Animals↗
PubMed1984

[25 cases of gastric smooth muscle tumors and review of the literature].

25 gastric smooth muscle tumors (12 symptomatic leiomyomas, 9 fortuitously discovered leiomyomas and 4 leiomyosarcomas) are presented. Follow-up has lasted from 9 months to 9 years. We have correlated the epidemiology, symptoms and anatomopathology with the evolution of these cases, in an attempt to single out specific features of benign and malignant forms. The most relevant macroscopic criteria of malignity are: a tumor measuring over 5 cm in diameter, widespread intratumoral necrosis. The histologic degree of malignity depends on several criteria, of which the most important are: the number of mitoses per high power microscopic field, cellular pleomorphism. Barium meal detects all symptomatic gastric smooth muscle tumors, and echography has the advantage of objectivizing intratumoral necrosis. For benign as well as malignant tumors the excision should be minimal, leaving a 2 cm safety margin. Simple enucleation is ruled out. If possible, metastases should be removed with the same safety margin. There is a good correlation between histologic type and prognosis. One case in 4 is associated with another malignancy.

Humans↗
PubMed1983

G0-G1 transition of rat hepatocytes detected by changes in nuclear chromatin condensation after in vivo treatment with phenobarbital.

The transition of hepatocytes from G0 to late G1-phase was studied in phenobarbital (PB) treated rats using visual and cytofluorometric evaluations of nuclear fluorescence patterns after quinacrine dihydrochloride (QDH) staining. In controls, about 90% of the nuclei showed bright nuclear fluorescence indicating G0-phase. After 10 days there was a reduction in fluorescence intensity which became more marked with continued PB treatment, indicating a shift from a resting G0 state to a later G1 phase of the cell cycle. The relevance of these findings for the understanding of tumor promoting properties of PB is discussed.

Animals↗
PubMed1983

Accessory cells in immune suppression. I. Role of I-A+ accessory cells in effector phase idiotype-specific suppression of myeloma function.

The suppression of MOPC 315 myeloma cells by idiotype-specific effector Ts requires the presence of non-immune AC. This requirement was demonstrated in cultures where myeloma targets and Ts were separated by cell-impermeable membranes or were in direct contact. The AC were adherent, radioresistant, and present in peritoneal exudates and in FcR+ as well as FcR- fractions of low density splenocytes; they bore cell surface I-A determinants and did not have to be H-2 compatible with myeloma cells and Ts. These studies demonstrate a novel role for Ia+ AC in immune regulation, and suggest that their accessory function may involve processing of T lymphocyte-derived suppressor factors or presentation of such factors to target cells.

Animals↗
PubMed1982

Suppression of anti-hapten antibody responses by hapten-specific cytolytic T lymphocytes: role of I-A-associated antigen on target B lymphocytes.

Cytolytic T lymphocytes (CTL) specific for 2,4,6-trinitrophenyl (TNP) determinants suppress the effector phase of a secondary anti-TNP antibody responses of murine syngeneic spleen cells in vitro. The cells mediating this suppression are hapten-specific, H-2-restricted, and possess properties typical of CTL. Moreover, the targets of the suppression appear to be antigen-primed B lymphocytes that are recognized by CTL via soluble antigen bound noncovalently to their Ig receptors. The effect of the CTL can be blocked by the addition of monoclonal antibodies directed against I-A molecules but not I-E or H-EK-encoded molecules on the target B cells, even in strain combinations in which the CTL-B cell interaction is restricted only by the H-2K and I regions of the MHC. This result suggests that B lymphocyte-bound antigen tends to associate preferentially with I-A rather than H-2K/D-encoded determinants, and that the suppressive effect of the CTL population is attributable to the minor subset that recognizes hapten-modified Ia antigens. These findings are also discussed in terms of the possible immunoregulatory function of Ia-restricted CTL.

Animals↗
PubMed1981

[Cystadenomas and cystadenocarcinomas of the pancreas].

Benign or malignant cystadenoma of the pancreas is a rare but not exceptional tumor. Up to present, 300 of the former and 100 of the latter have been reported in the world literature. Three personal observations are reported, comprising 2 benign cystadenomas, the first discovered on abdominal palpation and the second after massive bleeding of gastric varices and thrombosis of the splenic vein. After removal of the tumor both patients were alive 20 and 7 1/2 years later respectively. Total excision of a cystadenocarcinoma in a third case required 90% pancreatectomy with ensuing diabetes. A review of the literature shows that total excision of a cystadenocarcinoma is always justified since the survival rate approximates 70%. This contrasts singularly with the catastrophic prognosis of pancreatic adenocarcinoma.

Cystadenocarcinoma↗
PubMed1981

[Therapy of purulent peritonitis. Documentation of 78 cases and experience with taurolin (author's transl)].

From three different surgical departments 78 patients with purulent peritonitis are analyzed according to cause, origin, and extent of peritonitis. Operative therapy is presented. As additional antibacterial therapy the new chemotherapeutic agent, Taurolin, with antiendotoxin-effect is used. The postoperative course (temperature exceeding 38 degrees C, secondary wound healing, day of discharge, and serious complications) is correlated with pre- and intraoperative parameters; for instance, 1. postoperative fever occurs in one half of the patients, more frequently following perforation of stomach and duodenum; 2. every second patient shows secondary wound healing, this happens even more often in peritonitis arising from biliary disease or appendicitis; 3. in 29.5% of the patients serious complications arise, especially in patients with peritonitis originating in stomach, small intestine or large bowel; 4. overall mortality of 11.5% is surpassed in patients with peritonitis originating from small intestine or large bowel. The so-called peritonitis-index (calculated on the basis of pre- and intraoperative factors) shows a significant difference between survivors and patients dying during the postoperative course. In 80% of the 78 patients with purulent peritonitis taurolin was effective as a substitute for the usual antibiotics.

Adult↗
PubMed1981

Mechanical versus pharmacologic prevention of deep venous thrombosis.

The prevention postoperatively of deep venous thrombosis was studied using three different regimens in 227 patients undergoing surgical procedures. Seventy-six patients received 5,000 units of heparin subcutaneously and 0.5 milligrams of dihydroergotamine twice a day. In 76 patients, intermittent pneumatic compression of the legs was applied preoperatively and postoperatively with active physiotherapy. The last 75 patients received subcutaneously 5,000 units of heparin each eight hours. Systematic deep venous thrombosis detection was carried out using both the 125I fibrinogen test and the Doppler method, being confirmed by phlebography if positive. The 125I fibrinogen test proved to be more sensitive and more specific. The incidence of deep venous thrombosis and pulmonary embolism were comparable in the groups, mechanical prophylaxis being as effective as the two other regimens. No side-effects were noted with the use of intermittent compression boots. A venoconstricting agent associated with heparin may permit smaller doses with the same prophylactic effect.

Adult↗