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Biomedical subjects

G Mayer

Publications and source records attributed to G Mayer.

At least 325 records · Page 18Linked to original sources
PubMed1975

Lymphosarcoma, cold urticaria, IgG1 monoclonal cryoglobulin and complement abnormalities.

A patient with lymphosarcoma and cold urticaria showed evidence of complement activation by the classical pathway with low levels of the early complement components, normal levels of late acting components, normal functioning of the alternate pathway and reduction of the C1-inhibitor level. The serum contained an IgG1 monoclonal cryoglobulin responsible for the complement activation. In vitro tests demonstrated a high capacity of the serum to activate C1.

Cold Temperature↗
PubMed1975

Synthesis rates of albumin and fibrinogen in patients with protein-losing enteropathy and in a patient recovering from protein malnutrition.

Using the 14C carbonate method of McFarlane, the synthesis rates of albumin and fibrinogen were determined in four patients with protein-losing enteropathy, in one patient during the recovery phase after severe protein malabsorption and in nine control patients. The following results were obtained: (1) The synthesis rates of albumin and fibrinogen were significantly increased in all patients studied. (2) All patients had low serum albumin levels. The increase in albumin synthesis rate was remarkably uniform in all patients, the average being 645 mg/kg/day or 2.7 times the mean control value. (3) Plasma fibrinogen levels were normal in all patients. The fibrinogen synthesis rate varied over a wide range from 42.1 to 199.3 mg/kg/day, i.e. 2-8.5 times the control value.

Adult↗
PubMed1975

Synthesis rates of albumin and fibrinogen during and after acute hepatitis.

Synthesis rates of albumin and fibrinogen were determined in six patients with acute virus hepatitis and in nine control patients using the 14C carbonate method of McFarlane. Five patients were restudied several weeks after complete recovery. The following results were obtained. (1) The mean albumin and fibrinogen synthesis rates in the control group were 238.8 and 23.5 mg/kg/day, respectively. (2) In two patients with mild courses of hepatitis and in one patient studied during the early phase of a rapid and fatal course the albumin synthesis rate during the acute disease did not differ from controls whereas fibrinogen synthesis rate was slightly increased. (3) Three patients with severe hepatitis showed a definite decrease in albumin and fibrinogen synthesis rates, the lowest value being 76 mg/kg/day for albumin and 6.3 mg/kg/day for fibrinogen. (4) The decrease in plasma protein synthesis correlated neither with serum transaminase or bilirubin levels nor with plasma albumin or fibrinogen concentrations during the acute phase. (5) The two patients with the lowest albumin and fibrinogen synthesis rates also showed a definite decrease of the prothrombin index during the acute phase. Both patients presented very prolonged courses of the disease. (6) In all patients studied twice, plasma protein synthesis rates were normal after recovery.

Acute Disease↗
PubMed1975

[Relative concentration of deoxyribonucleic acid in the experimental deciduoma and the blastocyst of female rats: cytophotometric study].

Polyploidy level of experimentally induced deciduomata was determined by cytophotometric measures of DNA-Feulgen, with the "Ultramikrospektrophotometer UMSP Zeiss" by scanning. The antimesometrial tissue reached 32 n, 72 H after the uterine trauma, whereas the mesometrial part did not exceed a 4 n polyploidy level. With the same technics we studied the ovarian hormone, its action upon the blastocyst cellular cycle. In delayed blastocysts, synthesis was never found. OEstradiol removed the inhibition and DNA synthesis then starts again.

Animals↗
PubMed1975

[Does estradiol act in a unique way during progestation in the female rat? I. Uptake and retention of estradiol 17beta in the uterus of castrated rats under the influence of uterine distension].

In castrated female rats, uterine distension resulted in an increased uptake of tritiated oestradiol within the period studied (from 10 minutes to 24 hours after distension), whereas progesterone 14C incorporation was not increased. Using cold hormones (progesterone or oestradiol) before injection of radioactive ones, wer were able to demonstrate the specificity of this uptake 3.5 hours or 24 hours after initiation of distension. These results suggested that the oestradiol receptor may be synthetized without direct hormonal action. They are discussed with regard to oestradiol action, particularly during progestati-n and at the time of ovum implantation.

Animals↗
PubMed1975

[Cytophotometric determination of the relative amounts of deoxyribonucleic acid in the nuclei of blastocysts during normal and retarded implantation in the rat].

Cytophotometrics measures of DNA-Feulgen were realized in normal and delayed implantation blastocysts of the rat. During afternoon of the 5th day of progestation, blastocysts were of two types: those nuclei of which were in G1 gap and those nuclei of which were synthetising DNA. In delayed implantation, blastocyst nuclei were in G1 or G2 gap. Mitosis were rarely seen. After oestrogen injection DNA-synthesis started again. Cell kinetics before ovoimplantation is discussed.

Animals↗
PubMed1975

[Experimental rat deciduoma: histoenzymology].

The modifications of enzymatics activities which involved dehydrogenases (LDH, MDH and G6PDH) alkalines phosphatases (Ph. Alc., ATP/as at Ph 7,2 and Ph 9,4) and hydrolases (Ph Ac. and beta Glu) were studied during the experimental deciduomata evolution in the Rat from the 5th to the 9th day. One the 5th day the uterus were used as control. Dehydrogenases and alkalines phosphatases activites appeared in isolated cells of sub-epithelial and middle antimesometrial stroma on the 5th day. Then, on the 6th day, they distributed themselves in strings of 8 to 10 cells. On the 7th day, they were regulary arranged in the decidual area. The growing decidual tissue was always surrounded by an hydrolysis activity.

Acid Phosphatase↗