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Biomedical subjects

G May

Publications and source records attributed to G May.

At least 127 records · Page 7Linked to original sources
PubMed1980

Spontaneous rupture of cadaver kidney allotransplants: how successful is a repair? Report of 22 cases and review of the literature.

Spontaneous rupture of the transplanted cadaver kidney is not rare in the early posttransplant period. Experience with this complication in 22 of 364 kidney transplantations performed from 1968 to 1978 is reviewed. Rupture is associated with typical symptoms and immediate exploration is mandatory. If the diagnosis and surgical repair is delayed for more than 24 h, the outcome is poor. This study emphasizes the possibility and necessity of conservation and repair of the ruptured allograft. In 15 out of 22 cases of rupture, graft repair was performed and normal graft function could be restored with long-term success in 11 of the 15 cases.

Cadaver↗
PubMed1979

[Immunity against poliomyelitis in the German Federal Republic (author's transl)].

The immunity of the populations of several countries of the GFR against poliovirus 1, 2 and 3 was investigated in 11 laboratories. Sera of 4707 persons aged 0 to 30 years were assessed for neutralising antibodies (serum dilution 1:4) against the 3 types of poliovirus. 34.5% of the 4707 investigated sera had no neutralising antibodies at least against one type of the poliovirus, 4.7% showed no antibodies against all 3 types of the virus. Especially children aged 0 to 4 years were protected incompletely against the 3 types of poliovirus. In comparison with similar investigations of 1969 and 1972 no decisive change of immunity of the population of the GFR against poliomyelitis has occurred.

Adolescent↗
PubMed1979

Karyotypic variations in human meningioma cell cultures under different in vitro conditions.

Examined were how changes of the culture medium, cultivating procedure and cultivating time will influence numerical representation of different karyotypes in a total of 27 cell cultures of meningiomas with two or more cytogenetically distinguishable cell lines. It could be shown that in medium I (80% Mc Coy 5 A, 20% fetal calf serum) more cell lines with a higher degree of hypodipoidy occurred than in medium II (50% TC 199, 40% bovine amniotic fluid, 10% calf serum). The number of cells with normal karyotype was higher in cultures which were grown from trypsinized biopsy material in stationary flasks when compared to particle cultures in roller tubes. Cells with a normal karyotype also increased after 1--6 subcultures. By demonstration of SV 40 tumor antigen it could be shown in two cultures that these normal mitoses derived from tumoral and not from stromal tissue.

Antigens, Viral↗
PubMed1979

SV40-related T-antigen expression in human meningiomas with normal and G-22-monosomic karyotype.

Six of 16 meningiomas tested in early subcultures by indirect immunofluorescence showed SV40 T-antigen. Two different antisera specific for T-antigen were used. One serum gave a positive reaction with six tumours and the other with only two. In one T-antigen positive meningioma, the typical nuclear fluorescence changed, beginning with the second subculture, into an unusual brilliant granular pattern irregularly distributed over the nuclei. In six meningiomas, a specific chromosome aberration (monosomy G 22) was established. However, up to now, no clear correlation between karyotype and T-antigen expression could be found: cells from three meningiomas with positive reactions had normal karyotypes, whereas those from three tumours with typical chromosome loss showed no T-antigen.

Antigens, Neoplasm↗
PubMed1979

Effect of high-dose prednisone on renal hemodynamics of normal and transplanted dog kidneys.

The effect of prednisone therapy on renal hemodynamics was studied in normal, autotransplanted as well as homotransplanted dog kidneys. After intravenous administration of prednisone (8 and 16 mg/kg/min) the total blood flow decreased and vascular resistance increased significantly. This effect was more pronounced if the drug was directly injected into the arteria renalis. The same changes were observed in autotransplanted and homotransplanted kidneys and in kidneys in rejection. Our results suggest that high dosage of prednisone decreases the renal blood flow and this adverse effect has to be considered in the therapy. The administration of the drug directly into the arteria renalis may have to be avoided.

Animals↗
PubMed1979

Clinical experiences in the Gambro-preservation unit: analysis of 101 human cadaver kidneys.

101 human cadaver kidneys were preserved by means of hypothermic pulsatile perfusion in the Gambro perfusion unit with human albumin as perfusate. Perfusate flow and some biochemical parameters were assessed during perfusion and correlated with renal function after transplantation. There is a good correlation between perfusate flow and recovery of physiological renal function. LDH released to the perfusate as viability test is of limited value: a direct correlation was only found between LDH activity and perfusion time, and LDH activity and ischemia time. Determination of pH and lactic acid level 1 h after beginning of perfusion is without practical value according to our experience. The quality of albumin in perfusion solution influences the immediate graft function.

Adult↗
PubMed1979

[Reproduction following kidney transplantation (author's transl)].

Reported in this paper are the first two pregnancies and childbirths in the GDR following kidney transplantations. The point is made that pregnancy following kidney transplantation should remain to be a rare exception, though the courses were favourable in both cases described. Reference is made to most suitable forms of anticonception.

Adult↗
PubMed1978

[Biochemical parameters for determination of graft viability during the early postoperative period (author's transl)].

In 54 patients with graft failure the changes of urine sodium concentration and of urinary enzyme activities (alanine aminopeptidase, AAP) were investigated. It was found that: (1) the kidneys with irreversible acute tubular necrosis are characterised by high urine sodium level, and low AAP activities. These changes correspond to the end stage of renal insufficiency. (2) Low concentration of sodium and extremely high AAP excretion are characteristic in grafts with severe rejection episodes. (3) If kidneys lost their function due to irreversible rejection, the biochemical variables showed the same changes as in the first group. We concluded that by continuous determination of sodium levels and enzyme activities in urine and by their correlation it is possible to detect the non-functioning grafts in the early posttransplantation period.

Alanine↗
PubMed1978

Frequency of leukopenia incidents following azathioprine therapy after kidney transplantation.

The frequency of leukopenia incidents and its dependence on the dose of azathioprine and kidney function were analyzed in 149 patients during the first 3 months after kidney transplantation. The results were compared with the data of 42 transplantation centers of the world. We found that the frequency of leukopenia increases significantly following azathioprine dosage exceeding 1.99 mg/kg body weight/day. The toxicity of the drug depends on the kidney function. Most of the leukopenia incidents were detected during the first 5 weeks after kidney transplantation. In 70% of the cases a first leukopenia incident is followed by a second. Low azathioprine dosage after the first episode diminishes the number of second incidents.

Azathioprine↗
PubMed1978

[Antiviral effect of aqueous plant extracts in tissue culture].

The aqueous extracts from 178 kinds of medicinal plants belonging to 69 families were examined from the point of their virustatic activity against herpes-, influenza-, vaccine- and poliovirus. 75 kinds proved to be virustatic against one or more kinds of virus. Nearly one-third of the active plants belong to families that are known as especially rich in tannin. Besides the virustatic activity a great number of extracts showed also a cytostatic activity.

Antiviral Agents↗
PubMed1978

[Results of 289 cadaver kidney transplantations at the Berlin-Friedrichshain centre (author's transl)].

Developement and organization of kidney transplantation in the GDR was studied, with data of 289 patients who underwent transplantation at the Kidney Transplant Centre, Berlin-Friedrichshain being analyzed. The five years graft survival was 42% and the patients survival 62%. In case of combined treatment of transplantation and dialysis it was 70%. The main cause of transplant failure was rejection with a frequency of 12,1%. On the basis of an improved immunosuppression regime the mortality rate decreased from 37,6% to 12,3%. The introduction of a new method of ureteroneocystostomy resulted in a lower rate of urological complications. The importance of the preparation of the recipients, of the HLA-tissue typing as well as the influence of blood transfusion on the late prognosis of grafts will be discussed.

Berlin↗
PubMed1977

Long-term haemodialysis-an enhancing factor for cadaveric graft survival.

In 220 consecutive cadaveric kidney transplants, graft survival in patients dialysed for a period of two years or longer was significantly greater than in those dialysed for less than two years. More blood transfusions were received and the formation of HLA antibodies was greater in the group dialysed for more than two years. A positive cross match was the basis for excluding 21% of the HLA positive patients from transplantation during a one year period of observation. When these same HLA positive patients had more than two subsequent opportunities for donor-recipient selection the exclusion rate dropped to 2%. The longer period of dialysis with more blood transfusions had a favourable influence on cadaveric graft survival whereas the formation of HLA antibodies had a negative influence. Even in HLA positive patients graft survival was better in the long-term dialysis group when compared with the group dialysed for a shorter period. These results suggest that longer dialysis with more blood transfusions represents an enhancing factor for cadaveric kidney grafts.

Blood Transfusion↗