Search PubMed⌕ Search

Biomedical subjects

G Marconi

Publications and source records attributed to G Marconi.

94 records · Page 6Linked to original sources
PubMedDate not supplied

[Progressive supranuclear palsy: description of a case of early occurrence associated with muscular atrophies (author's transl)].

A case of Progressive Supranuclear Palsy (P.S.P.) of early onset (38 years) is described, with somewhat atypical features: the patient was oligophrenic, had no pseudobulbar signs, but there was some muscular atrophy, particularly of the shoulders girdle. On examination there was a slight cortical and cerebellar atrophy on the air encephalogram. Electromyography showed signs of damage to the lower motor neurone which was confirmed by muscular biopsy. In the literature a muscular atrophy in association with P.S.P. is rarely reported clinically although in some cases studied histologically there was degeneration in the nuclei of the cranial and spinal motor nerves. The present case may be an example of such widespread degeneration.

Atrophy↗
PubMedDate not supplied

Cell cycle and growth regulation in RAS2 mutant cells of Saccharomyces cerevisiae.

Yeast cells carrying ras2 temperature-sensitive mutations undergo a specific arrest in the prereplicative unbudded phase of the cell cycle when they are shifted to non-permissive temperatures. At 36.5 degrees C, in spite of their abnormally large cell size, bulk protein synthesis and accumulation rates are depressed in ras2 temperature-sensitive cells in comparison with isogenic wild type. At the same temperature, total RNA synthesis and accumulation rates are much more inhibited, suggesting that a defective Ras2/cAMP pathway alters the coordination between RNA and protein synthesis rates. The preferential RNA synthesis inhibition is correlated to a specific inhibition of the synthesis of the 35S rRNA precursor. These findings, taken together with the results of previous analyses, are in favour of a control by the cAMP pathway on rRNA biosynthesis.

Cell Cycle↗