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Biomedical subjects

G M Cook

Publications and source records attributed to G M Cook.

82 records · Page 5Linked to original sources
PubMed1968

The electrophoretic mobility of normal and leukaemic cells of mice.

1. The pH-mobility relationships for saline-washed cells from a mouse strain of acute lymphoblastic leukaemia were examined before and after treatment with lower aldehydes, diazomethane and neuraminidase (EC 3.2.1.18). 2. The content of sialic acid released into the supernatant fluid of neuraminidase-treated cells was measured. 3. The stability of the charge-determining structures to temporary changes in environment (pH and ionic strength) was established. 4. Similar measurements were made on lymph-node cells obtained from non-leukaemic mice (a resistant and a leukaemia-susceptible strain were examined). 5. It is deduced that both the malignant and the non-malignant cell possess two dissociable acid functions at the cell surface, a carboxyl group of sialic acid and another acidic group(s), probably carboxyl, of pK 3.0-4.5. The malignant cells, however, have a basic dissociable function not present in the non-malignant types. 6. Suggestions are made as to how the difference in surface chemistry may be related to the problem of malignancy.

Aldehydes↗
PubMedDate not supplied

"Spray, Spray, Spray!": insecticides and the making of applied entomology in Canada, 1871-1914.

As insecticides were adopted by Canadian farmers and fruit-growers after 1871, the resources conferred on economic entomology by the Dominion and Ontario governments grew. In 1886, with the establishment of the Experimental Farms system, James Fletcher, the Dominion entomologist and botanist, and his colleagues inherited the task of promoting insecticides to orchardists and others. In 1898-1900, in response to the arrival in Ontario of the San Jose scale, Canada and Ontario adopted laws mandating the use of insecticides, as sprays and fumigants, in orchards and at plant quarantine stations. To meet the resulting demand for trained technicians and scientifically-minded farmers, the institutions of applied entomology federally and at the Ontario Agricultural College were further developed. In 1910, after a decade of rapid diffusion of insecticides, Parliament adopted the Destructive Insects and Pest Act, thus creating a national system of horticultural hygiene.

Agriculture↗