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Biomedical subjects

G Lux

Publications and source records attributed to G Lux.

At least 73 records · Page 4Linked to original sources
PubMed1988

Laserlithotripsy of common bile duct stones.

Endoscopic retrograde laser lithotripsy of common bile duct stones is a new technique which can be carried out through the endoscope without anaesthesia using ordinary endoscopic equipment. In the method described here a flashlamp pulsed Neodymium YAG laser (wave length 1064 nm) was used. Light energy was transmitted along a highly flexible quartz fibre with a diameter of 0.2 mm. This new technique was used in nine patients with concrements in the common bile duct, which could not be removed with the established endoscopic techniques. In eight of the nine the concrements (maximum diameter 4.7 x 3.1 cm) could be fragmented and in six the fragments could be extracted from the common bile duct. The total energy required was 80-300 J; complications were not observed.

Aged↗
PubMed1988

Chronic pancreatitis and diabetes mellitus: plasma and gastroduodenal mucosal profiles of regulatory peptides (gastrin, motilin, secretin, cholecystokinin, gastric inhibitory polypeptide, somatostatin, VIP, substance P, pancreatic polypeptide, glucagon, enteroglucagon, neurotensin).

A disturbed intraduodenal milieu and pancreatic scarring in advanced chronic pancreatitis (CP) may lead to changes of gut and pancreatic hormones. In the present study, the gastroduodenal mucosal content of several regulatory peptides was determined in 8 patients with severe calcific CP and 8 healthy volunteers. In addition, hormone release into the bloodstream was estimated after intraduodenal acid/glucose stimulation in the control subjects and 8 CP patients each with or without secondary diabetes mellitus (DM), and in 8 patients with juvenile DM, so that disturbed gut hormone release could be attributed either to CP or DM. While VIP release into the circulation was similar in all participants, mucosal levels of VIP and substance P were significantly elevated in the duodenal bulb and descending duodenum of CP patients. The somatostatin content of gastroduodenal mucosa in CP was at least as high as in normals. Gastrin was significantly more abundant only in the duodenal bulb of CP patients, while plasma gastrin was normal. Duodenal CCK concentrations tended to be elevated in the duodenal bulb, but not significantly. The release of secretin seemed to be higher in type-1 diabetics than in CP patients. The mucosal pattern of GIP was nearly identical in CP patients and controls. Compatible with this finding, the GIP release did not show any peculiarities in CP with or without DM or in DM. Basal and stimulated plasma levels of motilin were abnormally high in CP. Pancreatic polypeptide plasma levels were normal in DM, but significantly reduced in CP, especially in CP with DM. Fasting PP and stimulated pancreatic enzyme outputs were linearly related.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

A cuffed tube for the treatment of oesophago-bronchial fistulae.

An oesophageal tube provided with a foam-rubber cuff is described. The outside diameter of the cuff can be diminished while the tube is being introduced. After implantation, the expanded foam-rubber cuff achieves additional sealing of the oesophago-bronchial fistula. The tube described is suitable for sealing off oesophago-bronchial fistulae in the absence of the tumour-induced stenosis of the oesophagus.

Carcinoma, Squamous Cell↗
PubMed1987

Colonic haemorrhage from solitary submucosal vessels diagnosed by lower gastrointestinal Doppler-endoscopy.

The case of a 21-year-old woman presenting with acute gastrointestinal haemorrhage is reported. By means of Doppler-endoscopy, a solitary minute polyp located in the proximal ascending colon, which revealed arterial pulsation, was detected, and removed with the aid of forceps. The histological work-up revealed thick-walled, in part dilated, vessels located in the lamina propria and in the submucosa. Following endoscopic sclerotherapy, the patient has now been haemorrhage-free for the past 6 months. The lesion is very probably a Dieulafoy-like erosion, an entity which was previously known only in the stomach and jejunum, but which in more recent times has also been observed in the colon.

Adult↗
PubMed1987

Biopsy histamine in ulcerative colitis and Crohn's disease.

The histamine content of biopsy specimens obtained from patients with ulcerative colitis (UC), Crohn's disease (CD), or polyps was measured in vitro. This was done using colonic and rectal mucosa taken from affected and healthy tissue. In general, the results demonstrate a significantly higher histamine content in patients with UC. This was true with respect to colonic as well as rectal mucosa. Moreover, affected mucosa contained significantly more histamine than normal in UC and in CD. The histamine content of colonic and rectal mucosa was similar within each patient group. However, specimens from patients with UC again contained significantly more histamine than did those of patients with CD. The data underscore a distinct pathomechanism in UC and in CD. Therefore, determination of the histamine content of biopsy specimens may be an adjuvant criterion for the discrimination of different inflammatory bowel diseases.

Adult↗
PubMed1987

Ischaemic colitis in a patient treated with glypressin for bleeding oesophageal varices.

This paper reports a case of ischaemic colitis observed in a male patient with acute oesophageal variceal bleeding treated with Glypressin (triglycyl lysine vasopressin). The therapeutic effect of this substance depends on the lowering of the portal vein pressure brought about by a vasoconstriction of the vessels of the splanchnic region. The undesired complication of ischaemic colitis occurred as a result of a reduction in blood flow to the colonic mucosa.

Adult↗
PubMed1987

[Drugs modifying motility in ulcer therapy].

The outstanding success of H2-blocking agents in ulcer therapy proves gastric acid as a dominating factor in the pathogenesis of ulcers. Motility disturbances can be demonstrated in ulcer patients but up to now in therapeutic terms played only a minor role. The therapeutic success of the antimuscarinic drug pirenzepine which inhibits only gastric secretory volume without influencing gastric pH but exerting a significant influence on interdigestive motility of the upper gastrointestinal tract reestablishes this factor to be of pathogenetic relevance. The pathophysiological factor of motility disturbances in the etiology of gastric ulcers is stressed also by the results of a recent therapeutic study comparing ranitidine and cisapride, where the motility-stimulating benzamide showed exactly the same rate of success as the H2-blocker; this holds true for both healing rate and symptomatic improvement. Therefore as far as chronic gastric ulcer is concerned a combination therapy should be preferred thus avoiding the side-effects of a strong and long lasting suppression of gastric acid secretion.

Cisapride↗