Search PubMed⌕ Search

Biomedical subjects

G Lose

Publications and source records attributed to G Lose.

At least 145 records · Page 8Linked to original sources
PubMed1987

Urine eosinophil cationic protein in painful bladder disease.

Urine eosinophil cationic protein (U-ECP), blood eosinophils and eosinophils in bladder biopsy specimens were studied in 30 patients with painful bladder disease (15 with detrusor mastocytosis, i.e. interstitial cystitis (IC) (greater than or equal to 28 mast cells/mm2 in the detrusor muscle) and 15 patients without detrusor mastocytosis). In patients with IC the median concentration of U-ECP was 140 arbitrary u/l versus 14 arb. u/l in the remaining patients (P less than 0.001). The mean peripheral leukocyte count was significantly lower in the IC group (P less than 0.05). Tissue infiltration with eosinophils was found in 43% of the bladder biopsies from patients with IC compared with 4% of the biopsies in the remaining patients (P less than 0.05). A negative correlation between peripheral eosinophils and U-ECP was found in the patients with IC (r = 0.52, P less than 0.05). These results suggest that eosinophils are attracted to the inflammatory site in the bladder wall where ECP is released. Eosinophils thus seem to participate actively in the inflammatory process. U-ECP seems to provide valuable diagnostic information when diagnosing IC in patients with painful bladder disease. It is suggested that ECP might be involved in the process of tissue destruction in IC.

Adult↗
PubMed1987

Vaginal repair in female motor urge incontinence.

Sixteen consecutive female patients with motor urge incontinence underwent vaginal repair operation. The patients were reevaluated after a mean follow-up of 37 months (range 8-72 months). Detrusor instability disappeared in only 31% of the patients after surgery which corresponds to the subjective and the objective cure rate. High pressure instability (contractions greater than or equal to 25 cm H2O) and/or a high instability index (greater than 1) were found to predict significantly a very poor prognosis. It is concluded that vaginal repair is an ineffective surgical procedure in patients with motor urge incontinence.

Adult↗
PubMed1987

The predictive value of the third day temperature in the decision whether to continue or terminate antibiotic treatment in perforated appendicitis.

The third day temperature is frequently used in the decision whether to continue or terminate antibiotic treatment following appendicectomy in perforated appendicitis. To assess the value of the third day temperature in predicting intraperitoneal infectious complications we studied 235 consecutive patients treated with a 3-day course of cefoxitin after surgery for perforated appendicitis. The results demonstrated that regardless of the level of elevated temperature chosen, the predictive value ranged between 16 and 33%. In consequence, elevated third day temperature per se does not provide any rational basis for continuing antibiotic treatment in order to prevent intraperitoneal infectious complications following appendectomy in perforated appendicitis.

Abdomen↗
PubMed1987

Voiding difficulties after colposuspension.

To study subjective and objective changes of micturition after colposuspension, 80 patients were evaluated before and after surgery. It was found that colposuspension may introduce an element of urethral obstruction, which leads to a significant proportion of immediate as well as late voiding difficulties. Thus, 25% of the patients developed severe voiding difficulties in the immediate postoperative course. Low pressure voiding (Pdet less than 15 cm water) preoperatively was found to predispose significantly to immediate postoperative voiding difficulties. Another 20% developed late voiding difficulties. Increased urethral resistance preoperatively was found to predispose significantly to late postoperative voiding difficulties. Increased urethral rigidity is suggested as an underlying factor. Only four (5%) of the patients developed both immediate and late postoperative voiding difficulties. The detrusor pressure at maximum flow was found to be an unreliable parameter in assessing the true potential of the detrusor. It is emphasized that a thorough preoperative evaluation of both bladder and urethral function and the use of a proper surgical technique are required to avoid voiding difficulties after colposuspension.

Adult↗
PubMed1987

One-hour pad-weighing test for objective assessment of female urinary incontinence.

In a 16-month period the one-hour pad-weighing test proposed by the International Continence Society was used in 126 instances for objective assessment of the degree of incontinence in 81 women with urinary incontinence. The present study deals with applicability of the test, patient compliance, reproducibility of the test, and comparison of test results with conventional methods for objective assessment of urinary incontinence. In spite of a rather high mean age (55 years), 73 patients (88%) were able to perform the entire test program. In 85 tests (68%) the patients indicated the result to be in accordance with the daily leakage. The reproducibility of the test was relatively good (r = 0.68; P less than .01), but significantly better (r = 0.93; P less than .0001) when taking into consideration the bladder volume at test start and the diuresis during the test. When compared with the pad-weighing test, the stress test and voiding-cystourethrography gave false negative results in approximately half the cases. The one-hour pad-weighing test was found to be practical and useful in quantifying the degree of leakage in women with urinary incontinence.

Adolescent↗
PubMed1986

The Helmstein bladder distension treatment for tumours and severe bleeding.

The Helmstein bladder distension treatment was applied to 26 patients, who received a total of 70 treatments (52 for bladder tumour and 18 for severe bleeding; in 7 cases for both tumour and bleeding). In the T2 tumours total necrosis occurred in 27% of the cases, partial necrosis in 50% and no necrosis in 23%. Of the patients with total necrosis 64% had recurrences within 12 months. In the T3-T4 tumours only 33% had a temporary slight reduction of the tumour mass. In patients with severe bleeding from the bladder, haematuria ceased within 1 to 5 days after the treatment in 12 out of 18 cases. Bleeding, however, recurred after an average of 3 months. It is concluded that the treatment is useful in selected cases with multiple tumours of the bladder, and the method is effective in controlling severe bleeding from the bladder.

Aged↗
PubMed1986

Transient painful osteoporosis of the hip in pregnancy.

A 35-year-old patient is presented with transient painful osteoporosis of the hip during the last trimester of pregnancy. This syndrome, which was first described in 1959, is characterized by mechanical pain in one or both hips and profund osteoporosis occurring shortly before or during the third trimester of pregnancy. The clinical course is spontaneous recovery within a few weeks to several months postpartum. There seem to be no specific laboratory findings. The treatment is symptomatic including bedrest. Awareness of this syndrome should help to state the right diagnosis, to choose a proper treatment and to obviate unnecessary invasive investigations.

Adult↗
PubMed1986

Terbutaline (Bricanyl) in the treatment of female urge incontinence.

Fifteen women with idiopathic urge incontinence (8 motor and 7 sensory urge incontinence) were treated with a beta 2-adrenoceptor-stimulating agent, terbutaline (Bricanyl) for 3 months. A subjective effect on the symptoms urgency and frequency was found in 14 patients, and 12 patients (80%) became continent. In 6 of 8 cases the detrusor became stable. The drug was generally well tolerated; however, a high incidence of transient side effects were observed. Terbutaline seems to be valuable in the treatment of idiopathic female urge incontinence.

Adult↗
PubMed1986

Clinical pharmacology of the lower urinary tract. New aspects.

Neurohistochemical, electron-microscopic, pharmacological and urodynamic investigations have over the past 10 years led to a new concept of the innervation and function of the lower urinary tract. A survey is given of the peripheral innervation, transmitters and receptor functions in the parasympathetic, sympathetic, somatic and sensory innervation of the lower urinary tract. Based on this, rational principles of pharmacological treatment are outlined in the management of the most common dysfunctions of detrusor function and the urethral closure mechanism. Furthermore, a survey is given of dysfunctions of the lower urinary tract which may arise inadvertently during pharmacotherapy of disorders of other organ systems.

Adrenergic beta-Agonists↗
PubMed1986

Determination of eosinophil cationic protein in urine by an enzyme immunoassay.

An enzyme immunoassay has been developed which allows the determination in urine of eosinophil cationic protein (ECP). The antigen was prepared from urine from patients suffering from interstitial cystitis and found to be a 20,000 MW polypeptide. Eosinophil cationic protein has been determined in urine from normal people and in patients with interstitial cystitis and other bladder disorders. The results obtained using the enzyme immunoassay were compared with the results obtained with conventional radioimmunoassay. This new assay seems to be valuable in the diagnosis of interstitial cystitis.

Blood Proteins↗
PubMed1986

Three days cefoxitin in perforated appendicitis.

This study was undertaken to assess the efficacy and safety of a 3-day course of treatment with Mefoxitin (cefoxitin sodium, MSD) in patients with perforated or ruptured appendicitis. A series of 235 patients undergoing surgery for perforated or ruptured appendicitis were treated with cefoxitin for 3 days. Twenty-four patients (10%) developed wound infection and 28 (12%) developed an intra-abdominal abscess postoperatively. No side effects were observed during the study. Compared with the results of our previous series, where a 5-day course of cefoxitin was used, the incidence of wound infection was similar. However the incidence of intra-abdominal abscesses in the present series was significantly higher (p less than 0.01). The results seem to indicate that a 3-day course of cefoxitin is as effective as a 5-day course in controlling the incidence of wound infection following surgery for perforated or ruptured appendicitis, whereas the 3-day course seems to be inferior to a 5-day course in controlling the incidence of intra-abdominal abscesses.

Abscess↗
PubMed1985

Prophylactic phenoxybenzamine in the prevention of postoperative retention of urine after vaginal repair: a prospective randomized double-blind trial.

To investigate the effect of prophylactic phenoxybenzamine on the bladder emptying after vaginal repair operations, 41 consecutive patients, who underwent the Manchester operation or an anterior + posterior repair because of genital descensus, were allocated at random to either prophylactic phenoxybenzamine (PBZ-group) or placebo treatment in the postoperative course. Prophylactic phenoxybenzamine was found to produce an improved emptying function of the bladder, leading to a statistically significant reduced number of acute urinary retentions (P = 0.029), decreased time until spontaneous voiding (P = 0.026) and reduced volume of residual urine (P = 0.018). Furthermore, a reduced incidence of urinary tract infections was found in the PBZ-group. Prophylactic phenoxybenzamine treatment is recommended as an alternative to routine bladder drainage in preventing urinary retention following vaginal repair operations for genital descensus.

Adult↗
PubMed1985

Urethral sphincter electromyography with vaginal surface electrodes: a comparison with sphincter electromyography recorded via periurethral coaxial, anal sphincter needle and perianal surface electrodes.

Urethral sphincter electromyography recording via vaginal surface electrodes was compared to simultaneous sphincter electromyographic registrations obtained with a periurethral coaxial needle electrode and perianal surface or needle electrodes in 10 neurologically intact women. Qualitative similarity of the vaginal surface and periurethral needle electrode recordings was found. Based on this and our previous studies, we conclude that electromyographic recording with vaginal surface electrodes offers a simple and reliable technique to evaluate the striated urethral sphincter during routine urodynamic studies in women.

Adult↗