[Bone and joint scintigraphy in rheumatology].
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Biomedical subjects
Publications and source records attributed to G Lingg.
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Computer tomographic densitometry of the dorsum sellae shows decreasing density with increasing age. This reduction does not take place evenly, but increases markedly at the age of 50. Densities below twice a standard deviation of mean values suggest that there is porosis of the axial skeleton as well. This provides an interesting and useful piece of additional information during cranial computed tomography.
Experimental studies of patellae at autopsy and clinical CT-arthrographic examinations of 36 patients show that CT provides good demonstration of the retropatellar cartilage and its lesions. The value of the method compared with conventional radiographic examinations, arthroscopy and surgery is discussed.
Catecholamine-storing chromaffin cells, isolated from bovine adrenal medullae by collagenase digestion, were stimulated with carbachol at 37 degrees C; aliquots for controls were kept at 37 degrees C: Starting from this temperature, cells were ultrarapidly frozen with the use of a sandwich-propane-jet procedure and freeze-fractured. The replicas were analysed quantitatively for exocytotic activity: After stimulation the cell membrane displayed a significant increase of exo-endocytotic openings varying in size from 20 to 300 nm. The number of openings increased in parallel to the catecholamine output. At no stage could a clearing of membrane-intercalated particles (MIPs) be observed. Openings of all size classes were etchable. Results from the PF-face were comparable with those of the EF-face. We conclude that (i) exocytosis in isolated chromaffin cells starts as a focal event; the smallest possible stages are about 10 nm in size, (ii) fusion proceeds without previous rearrangement of MIPs, and (iii) the opening starts without formation of a diaphragm.
A lot of methods of measurement have been developed to record precisely the degrees of luxation and the deviations from the normal form in the hip joints of the child and adult. The orthopaedic surgeon needs those data for a preoperative "coxometric program" before performing acetabuloplastic operations with osteotomy, osteotomy of the pelvis and combined operations. Computed tomography yields a series of informations and of possibilities of measurements which can determine the operative procedure in particular. These informations concern among other things the dimensions of the dysplasia of the acetabulum in the horizontal plane with the extension of the posterior lip and the angle of the acetabular opening, furthermore the physiological or pathological congruence between the head of the femur and the acetabulum, the angle of antetorsion of the neck of the femur and, in the small infant, the direct noninvasive imaging of the tube of the capsule with imaging of possible obstacles to reposition.
A solid-cystic acinar cell tumour of the pancreas was found in four female patients. This particular form of benign pancreatic tumour is characteristically found in young women, often reaches a large size (2.5-10 cm), presents as a spherical mass in computed tomography or ultrasonography and does not show infiltrative growth or metastases. Tumours can be readily enucleated or resected. This type of tumour does not yet appear in the WHO classification of epithelial pancreatic tumours. It probably arises from the acinar cells. Accurate differentiation from previously known highly malignant acinar tumours is absolutely necessary on account of the good prognosis of this type of tumour.
The distribution of 99mTc-Sn-MDP in the thigh was estimated according to two different indices in 60 normal patients, 21 patients undergoing haemodialysis and one who had had a renal transplant. Deviation of the indices in these patients from the normal are significant. The indices were correlated with respect to their accuracy in detecting renal osteopathy with histomorphometry (as the reference method), radiological diagnosis, densitometry, parathormone assay and other laboratory tests. Accuracy of the method is high and, like histomorphometry, is over 90%.
The incidence of post-puncture haematomas following percutaneous renal biopsy in 23 patients (24 punctures) is reported. The incidence of renal haematomas was 29.1%. The diagnostic value of computer tomography and sonography is discussed. Amongst small haematomas (less than 7 ml. blood), which could only be demonstrated by computer tomography, 8.2% were purely intrarenal, 8.2% were sub-capsular and 12.3% showed combined intrarenal, subcapsular and perirenal bleeding. The incidence of sub-capsular and perirenal haematomas of 20.5% is considerably lower than has previously been reported in literature.
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Thirty-six patients with bacterial spondylitis and eight patients with hemispherical spondylosclerosis (Dihlmann 1981) were examined by conventional x-ray techniques, computed tomography, 99mTc-MDP scintigraphy and 67Gallium scintigraphy. Conventional radiology is adequate for making the diagnosis. Where there is doubt, however, and for observing the progress of the disease, CT and scintigraphy may be used. Hemispherical spondylosclerosis can be identified by means of these additional methods.
Six examples of aseptic necrosis of the epiphyseal end of the clavicle in adults are described. The radiological appearances are highly characteristic, allowing a definite diagnosis and exclusion of other conditions. The histological changes could be established by the examination of material obtained during resection and arthroplasty. The radiological differential diagnosis is discussed.
A randomized study of 2000 patients (1000 males, 1000 females) revealed two forms of the triangular hyperostosis of the ilium in female patients. The hyperostosis triangularis ilii, HTI, is also known as osteitis condensans. One form of HTI concerning women under the age of 50 is called the adult generative HTI, the other beyond the age of 50 senile degenerative HTI. These two forms are not evident in male patients. The 3.05% incidence of HTI in adults appeared to be higher than presumed till now. The sex incidence male/female of 1:1.6 diverges considerably from preceding investigations. Histomorphological studies of two autopsies of cases of senile degenerative HTI revealed no signs of inflammation. Statistical correlations of HTI with other chronic diseases of the pelvis and hip could doubtlessly and generally be established only for osteoarthrosis of the sacro-iliac joints in females beyond the age of 50 and in males as a matter of principle.
Autopsy examinations of patellae revealed that there is no statistical relationship between osteoarthritis and the different Wiberg and Baumgartl types of patella. Wiberg's and Baumgartl's types of patellae appear to be physiological form variants and without importance in the development of femoropatellar osteoarthritis. However, other morphological findings in the femoropatellar compartment, such as a ridge on the medial femoral condyle or a cartilagineous ridge on the medial part of the joint surface of the patellae may represent a prearthrotic factor.
Many papers have been published about the different types of measurements used in the evaluation of hip dysplasia in the pediatric age group. However, there are no publications that deal with this topic regarding adults. The authors present an initial series of measurements of the angle of the roof of the acetabulum in 100 randomized asymptomatic adult males. The normal value ranged from -10 degrees to +10 degrees. These measurements were correlated with those described by Wiberg. The combination of both methods yields highly reliable information in the evaluation of hip dysplasia.
The article reports on the x-ray morphology in 52 patients with Crohn's disease (part of a multicenter study for the purpose of therapy control). The most frequent morphological sign was the so-called "string sign", also known as Kantor's sign (55%). Changes in the mucosal relief were also very frequent (45%). Chief localisation was the terminal ileum (64%), exclusion affection of the colon being rare (8%). The formation of a fistula is described as the most important complication; a rare one occurred between rectum and vagina. In two cases pseudopolypous changes were seen. The article also discusses the various aspects after surgery for Crohn's disease.
The article reports on the authors' own observation of a patient with duplication of the oesophagus. Basing on this case, the possibilities of the evolutionary origin are discussed briefly. The significance and decisive importance of x-ray film diagnosis in gastro-intestinal duplication is underlined.
In human genetics and orthopedics quite different answers have been given to the question of hereditary transmission and frequency of hip dysplasia in families of children with congenital hip dislocation. We therefore have made roentgenometric measurements of 110 parents of children with congenital hip dislocation. In 25% we found abnormal flat acetabulae, whereas 12% had pathologic deep hips. This may propose a new concept of morphology of congenital hip dysplasia.
The article gives a brief description of the characteristic features of the clinical and roentgenological course and the various stages of enteritis caused by Yersinia. Basing on three cases of ileitis caused by Yersinia, the far-reaching similarity with the early changes and even the advanced stages of Crohn's disease are demonstrated. Attention is drawn to the possibilities of differentiating between the two disease patterns.