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Biomedical subjects

G Lidin-Janson

Publications and source records attributed to G Lidin-Janson.

At least 55 records · Page 3Linked to original sources
PubMed1978

The homogeneity of the faecal coliform flora of normal school-girls, characterized by serological and biochemical properties.

The homogeneity of fecal coliform flora in 52 schoolgirls was studied by serotyping and biotyping 10 randomly selected colonies in one fecal culture from each child. Ninety-eight clones were identified and of these 52 were dominant and 46 were minor strains. The probability of including at least one isolate of the dominant clone in a small random sample of colonies was calculated to be 86% for one colony, 94% for 2, 97% for 3, 99% for 4, and 99.3% for 5 randomly selected colonies.

Adolescent↗
PubMed1977

Frequency of E. coli K antigens in urinary-tract infections in children.

The somatic (O) and casular (K) antigens of Escherichia coli from the urine of patients with acute pyelonephritis, acute cystitis, and asymptomatic bacteriuria, and in the faeces of healthy schoolchildren have been investigated. Typing antisera for sixteen capsular acidic polysaccharide K antigens were used, and five (numbers 1, 2, 3, 12, and 13) accounted for 70% of isolates from patients with acute pyelonephritis. These five K antigens were found to a lesser extent in the three other study groups. Thus, only a few K polysaccharides are associated with virulent properties of E. coli for the upper urinary tract. This finding is similar to the association of only some capsular types of pneumococci, meningococci, and Haemophilus influenzae with invasiveness. The identification of virulence markers for E. coli associated with upper-urinary-tract disease may permit more successful control with reference to preventive immunisation.

Acute Disease↗
PubMed1977

Listeric meningitis in the non-compromised host.

A small epidemic of listeric infection among non-compromised adults recently occurred in the western part of Sweden. All ten patients survived and the prognosis of listeric meningitis in non-compromised patients would seem to be considerably better than in the compromised host. A rapid initiation of ampicillin treatment (10-20 mg/kg of body weight daily) within 48 hours after onset of symptoms may be contributed to the excellent outcome in the present series besides a well-functioning intracellular killing mechanism which seems to be of the greatest importance in listeric infeciton.

Adult↗
PubMed1977

Comparison of Escherichia coli from bacteriuric patients with those from feces of healthy schoolchildren.

The properties of 709 strains of Escherichia coli isolated from feces of healthy schoolchildren were compared with those of 115 strains from the urine of girls with asymptomatic bacteriuria (ABU) detected in a screening program. These fecal strains were also compared with 45 strains that caused asymptomatic reinfections and 10 that caused symptomatic reinfections in the same group of girls. Typing of O antigen was done by direct bacterial agglutination, and K typing was done with a serum agar technique. Hemolytic capacity was assessed in solid medium. Sensitivity to the bactericidal effect of normal serum and minimal inhibitory concentrations of ampicillin were also determined. The strains isolated from girls who had reinfections of ABU were found to be a random sample of the fecal flora, but the strains from children with symptomatic reinfection were not. Strains from index patients with ABU differed from the other groups in a way that was indicative of adaptive changes in the structure of cell envelopes.

Adolescent↗
PubMed1977

Characteristics of antibiotic-resistant Escherichia coli in the rectum of healthy school-children.

During a 3-year period, 771 rectal swabs were taken from abacteriuric school-children. Out of 709 E. coli strains, each isolated from one faecal specimen, 102 were found to be resistant to one or more antibacterial agents, and 607 to be fully sensitive. Another 204 resistant strains were found by selection for antibiotic resistance. The antibiotic-sensitive and the resistant strains were found to be two somewhat different populations, distinguished by a different distribution of O antigen types. Also, the K1 antigen was more common among the sensitive than among the resistant strains. Resistant strains that were not O typable were very seldom haemolytic.

Adolescent↗
PubMed1977

Asymptomatic bacteriuria in schoolgirls. VI. The correlation between urinary and faecal Escherichia coli. Relation to the duration of the bacteriuria and the sampling technique.

The occurrence of the urinary strain in the anus, rectum and faeces was investigated in 27 girls with asymptomatic bacteriuria (ABU). In patients with bacteriuria of relatively short duration 46% of the faecal isolates were of the urinary strain as compared to only 18% in patients with bacteriuria of relatively long duration. In general the correlation between the urinary and faecal flora is striking at the time of establishment of ABU but diminishes with time. The diminished correlation may be due to two factors: firstly, the composition of the faecal flora changes with time. Secondly, the correlation may be obscured by complex changes in the properties of bacterial strains established in the urinary tract. Contamination by the infected urine did not seem to be a serious problem when the rectal mucosa was swabbed proximal to the anal canal.

Anal Canal↗
PubMed1977

Intestinal stimulation of the serum antibody response against Escherichia coli O83 antigen in healthy adults.

Ingestion of E. coli O83 bacteria preceded by intake of 2 g of NaHCO3 resulted in the bacteria appearing as a transient strain in the stool in 6 out of 11 healthy adult individuals. No rise in serum, urine or parotid fluid antibody levels against the crude O antigen from E. coli O83 bacteria could be detected using the enzyme-linked immunosorbent assay (ELISA) or the indirect haemagglutination (IHA) technique. In contrast, a serum antibody response was registered in four individuals with the ammonium sulphate precipitation (ASP) technique. The rise in antibody level was accompanied by an increase in relative average antibody avidity. Significantly lower levels of serum antibodies against the E. coli O83 and O6 antigens were recorded using the ASP technique as compared to those for O2, O4 and O75 antigens.

Adult↗
PubMed1977

Sulphonamides in the treatment of acute Escherichia coli infection of the urinary tract in women. Clinical and ecological effects of sulphasomidine and sulphalene.

28 non-pregnant women were treated with conventional doses of sulphasomidine or sulphalene for acute urinary tract infections caused by Escherichia coli. Both preparations were found to be effective in simple cystitis infection with sulphonamide-sensitive organisms. Also, both were found to exert a selective pressure favouring sulphonamide-resistant E. coli in the faecal flora.

Acute Disease↗
PubMed1976

Escherichia coli O antibody content in milk from healthy Swedish mothers and mothers from a very low socio-economic group of a developing country.

The antibody content of milk from healthy Swedish mothers was compared with that of milk from mothers of a very low socio-economic group in a developing country. Antibodies of various immunoglobulin classes against E. coli O antigens were determined with the enzyme-linked immunosorbent assay (ELISA). The milk antibodies which mainly belonged to the secretory IgA class appeared in similar concentrations in milk from the two groups using E. coli antigens of Swedish as well as Pakistani origin. The secretory IgA antibodies could be demonstrated in the stool of the breast-fed infants of the undernourished mothers. Also the concentration of serum IgG and IgA antibodies to E. coli O antigens were similar in the Pakistani and Swedish mothers. The serum IgM antibody levels of the Pakistani mothers were higher, however, presumably due to a higher frequency of infections. It was noted that the milk production decreased considerably upon the hospitalization of the healthy and well-to-do Swedish mothers. The small milk volumes of the undernourished Pakistani mothers suggest that the lactation failure observed was mainly due to inadequate milk flow and not to decreased milk quality. The results indicate the necessity of studying the nutritional, psychological and social factors responsible for low milk yield and add yet another reason to stimulate prolonged breastfeeding.

Adult↗
PubMed1975

Asymptomatic bacteriuria in schoolgirls. II. Differences in escherichia coli causing asymptomatic bacteriuria.

Three hundred and forty-three E. coli strains isolated from the urine of patients with asymptomatic bacteriuria (ABU), symptomatic cystitis, or pyelonephritis were analysed with regard to O group distribution and sensitivity to the bactericidal effect of normal serum. Strains of O groups 1, 2, 4, 6, 7, 16, 18 and 75 were found in 31.3% in ABU, in 58.7% in cystitis and in 79.8% in pyelonephritis. Spontaneous agglutination was noted in 45.2% of ABU, 6.5% of cystitis and 1.7% of pyelonephritis strains. The strains from patients with ABU were significantly more sensitive to the bactericidal effect of normal serum than were those from patients with symptomatic urinary tract infection. In some patients with untreated ABU, changes in the characteristics of the urinary strains isolated were noted. The strains tended to become spontaneously agglutinating as well as more sensitive to the bactericidal activity of normal serum. The strains found in patients with ABU probably had an altered cell wall compared with those found in patients with symptomatic infections such that they produce fewer symptoms and possibly be less virulent.

ABO Blood-Group System↗
PubMed1975

The effect of doxycycline and tetracycline hydrochloride on the aerobic fecal flora, with special reference to Escherichia coli.

The effect on the aerobic faecal flora of a 10-day course of doxycycline or tetracycline hydrochloride was compared in 36 patients with acute infections mainly of respiratory origin. The patients were treated in hospital with a well-developed barrier nursing technique. The proportions of isolates of Escherichia coli resistant to tetracyclines were significantly lower after 10 days' treatment with doxycycline (80%) as well as one month later (24%), compared to the figures for tetracycline HCI (100% and 46%, respectively). The resistant strains selected during therapy probably represented the community flora. Only a small increase in multiresistant strains occurred and no identical strains were found in different patients. Thus, it seems possible to limit the biological side-effects of tetracyclines by a good barrier nursing technique. An increase in the number of E. coli resistant to tetracyclines cannot be avoided, but is more limited when doxycycline is used.

Acute Disease↗