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Biomedical subjects

G Leyendecker

Publications and source records attributed to G Leyendecker.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Inguinal lymph node metastasis as primary symptom of endometrial carcinoma (author's transl)].

Two cases of postmenopausal women with inguinal lymph node metastases of papillary adeno-carcinoma are reported. Enlarged inguinal glands appeared for six months and two years, respectively. The search for the primary tumour site over several months was negative. The existence of an endometrial carcinoma had not been considered, because the symptom of vaginal bleeding was absent.

Adenocarcinoma, Papillary↗
PubMed1977

The effect of prostaglandin f2alpha on endocrine parameters in early pregnancy.

The luteolytic effect of prostaglandin f2alpha (PGF2alpha) has been well documented in a variety of primates. This property has not been proven in early human pregnancy. A study of the luteolytic activity of extraamnial administration of 5 mg PGF2alpha was carried out on 7 healthy women who were less than 6 weeks pregnant and on 4 women who were more than 9 weeks pregnant. Serum levels of 17beta-estradiol, 17-hydroxyprogesterone, progesterone and human chorionic gonadotropin (HCG) were measured by radioimmunoassay before, during and after the administration of PGF2alpha. Abortion was successfully induced in all the patients with early pregnancies, but in the control group of more mature pregnancies only one of the four women aborted. In the older pregnancies, the administration of 5 mg PGF2alpha caused no significant alteration in the serum levels of the measured hormones. In the younger pregnancies the serum concentration of 17beta-estradiol and progesterone decreased within hours after PGF2alpha administration. Serum 17-hydroxyprogesterone concentrations remained unchanged at a high level and declined significantly later in a manner similar to HCG. This discrepancy in the decline of 17-hydroxyprogesterone as opposed to progesterone and 17beta-estradiol may be explained by two mechanisms, the one mechanical, and the other secondary luteolytic. The marked increase of intrauterine pressure occurring within minutes after PGF2alpha instillation damages the fetoplacental unit. This leads to a decrease in the placental steroido-genesis and HCG production necessary for the maintenance of the corpus luteum.

Abortion, Induced↗
PubMed1976

[Endocrine regulation of the menstrual cycle].

Physiological data concerning the serum concentrations and the pituitary content of varian steroids and gonadotropins, respectively, are reviewed. On the basis of these physiological data results from experimental studies are critically evaluated as far as their significance for the understanding of the physiology of the cycle is concerned. Data from the literatur and results from own studies are incorporated in a concept of the endocrine regulation of the human menstrual cycle.

20-alpha-Dihydroprogesterone↗
PubMed1976

Experimental studies on the positive feedback effect of progesterone, 17 alpha-hydroxyprogesterone and 20 alpha-dihydroprogesterone on the pituitary release of LH and FSH in the human female. The estrogen priming of the progesterone feedback on pituitary gonadotropins in the eugonadal woman.

Administration of progesterone eugonadal women during the midfollicular phase of the menstrual cycle failed to induce a positive feedback effect on the serum concentrations of LH and FSH. The levels of estradiol in serum decreased following the injection of progesterone without a parallel change in LH and FSH concentrations indicating a direct ovarian effect of the exogenous progesterone. In the late follicular phase of the cycle, when preovulatory levels of estradiol were present in serum, or under a ethinyl estradiol treatment progesterone was able to induce an LH discharge indicating the requirement of an estradiol priming of the positive feedback of progesterone in eugonadal women. In order to establish the time required for a sufficient estrogen priming with preovulatory levels of estradiol in serum 3 mg of estradiol-benzoate were administered i.m. 1, 12 and 24 h prior to the administration of 30 mg of microcristalline progesterone in the midfollicular phase of the menstrual cycle, when progesterone alone did not cause an LH surge. Only when estradiol-benzoate was injected 24 h prior to the progesterone administration an LH surge reproducible in time course and magnitude occurred. Administration of estradiol-benzoate alone under these conditions did not cause an LH surge within the elapse of time after the injection when the progesterone induced LH surge occurred. Thus, these experiments demonstrate that a defined estrogen priming is required for the positive feedback effect of progesterone on the gonadotropin release in eugonadal women. Furthermore, progesterone levels in serum of about only 1--2 ng/ml were required for the induction of an LH surge indicating that under physiological conditions progesterone may have an supplementory effect on the primarily estradiol induced LH midcycle peak. 17-hydroxyprogesterone administered during the mid follicular phase of the menstrual cycle and under pretreatment with ethinyl estradiol failed to induce a positive feedback effect on the serum concentrations of LH and FSH, indicating that this steroid does not play a regulatory role on the midcycle LH release in women. 20alpha-dihydroprogesterone administered under the same experimental conditions as 17-hydroxyprogesterone seems to be able to induce an LH surge in serum provided there is an adequate estrogen priming.

20-alpha-Dihydroprogesterone↗