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Biomedical subjects

G Leyendecker

Publications and source records attributed to G Leyendecker.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Computed tomography and the clinical picture of carcinoma of the uterine cervix].

The clinical and computer tomographic findings in 142 patients with carcinoma of the body of the uterus have been compared. The CT findings at the first examination were then compared with the clinical results. The likelihood of a recurrence was related to infiltration of the parametrium. There was strong positive correlation between the CT findings during treatment and the probability of recurrences. The wealth of information provided by computed tomography makes any other form of investigation during tumour staging and during follow-up unnecessary.

Bone Neoplasms↗
PubMed1984

Pulsatile administration of Gn-RH in hypothalamic amenorrhea.

The physiological and pathophysiological basis of hypothalamic amenorrhoea are reviewed as well as the clinical results of chronic intermittent (pulsatile) administration of Gn-RH in the treatment of infertility. Hypothalamic amenorrhoea is considered to be the result of a deficient hypothalamic secretion of Gn-RH. By pulsatile administration of Gn-RH, which is a pre-requisite of normal pituitary gonadotrophic function, deficient endogenous Gn-RH is replaced. If an adequate dose of Gn-RH is provided, which takes into account the degree of impairment of hypothalamic function in the individual case, follicular maturation, ovulation and corpus luteum formation are achieved in nearly every treatment cycle. Although dependent also on factors other than the treated dysfunction, a high conception rate is achieved.

Adult↗
PubMed1983

The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle.

The effects of danazol on pulsatile luteinizing hormone (LH) release, basal LH and follicle-stimulating hormone serum levels, gonadotropin release induced by estradiol (E2) and gonadotropin-releasing hormone were examined in five eugonadal women. Danazol administration resulted in a significant suppression of follicle-stimulating hormone serum levels. LH concentrations and LH pulse frequency appeared to be reduced, but these changes did not reach statistical significance. The pituitary response to exogenous gonadotropin-releasing hormone was not altered. The stimulatory effect of E2 on LH secretion was completely abolished in one subject, severely diminished in three subjects, and unchanged in one subject. In addition, the time course of this response was altered. Serum prolactin concentrations were lowered, whereas basal E2 and progesterone levels did not seem to be affected.

Adult↗
PubMed1983

Induction of ovulation with chronic intermittent (pulsatile) administration of Gn-RH in women with hypothalamic amenorrhoea.

The physiological and pathophysiological basis of hypothalamic amenorrhoea are reviewed as well as the clinical results of chronic intermittent (pulsatile) administration of Gn-RH in the treatment of infertility. Hypothalamic amenorrhoea is considered to be the result of a deficient hypothalamic secretion of Gn-RH. By pulsatile administration of Gn-RH, which is a pre-requisite of normal pituitary gonadotrophic function, deficient endogenous Gn-RH is replaced. If an adequate dose of Gn-RH is provided, which takes into account the degree of impairment of hypothalamic function in the individual case, follicular maturation, ovulation and corpus luteum formation are achieved in nearly every treatment cycle. Although dependent also on factors other than the treated dysfunction, a high conception rate is achieved.

Amenorrhea↗
PubMed1983

Carcinoembryonic antigen in cervical cancer: a five-year follow-up.

Serum levels of carcinoembryonic antigen (CEA) were determined radioimmunologically before initiation of therapy in the serum of 142 patients suffering from carcinoma of the uterine cervix. The overall incidence of elevated CEA levels (above 12 ng/ml) was 39%. There was a positive correlation between the incidence of elevated CEA levels and the clinical stage of the disease. CEA levels before treatment had no prognostic value in patients matched for stage as far as median survival time was concerned. In contrast, CEA levels measured immediately after therapy in patients with initially elevated levels acquired prognostic significance. Thus, CEA measurements appear to be an additional tool in the follow-up of patients with cervical cancer.

Adult↗
PubMed1982

[CEA and the clinical course in advanced carcinoma of the uterine cervix (author's transl)].

The clinical course of six representative patients suffering from advanced carcinoma of the uterine cervix and with elevated and borderline levels of CEA in serum prior to therapy is correlated in detail with the pattern of CEA in serum during and after therapy. It is shown that there is a close correlation between the serum CEA pattern and the course of the disease. Thus, serial CEA measurements in serum appear to be of value in the follow up of patients with carcinoma of the uterine cervix.

Adult↗
PubMed1982

[Pulsatile treatment with gonadotropin-releasing hormone (Gn-RH)].

In this review an account is made on the physiological and pathophysiological basis as well as on the clinical results of chronic-intermittent (pulsatile) administration of Gn-RH in the treatment of infertility in hypothalamic amenorrhea. Hypothalamic amenorrhea is considered to be the result of a deficient hypothalamic secretion of Gn-RH, which is a prerequisite of normal pituitary gonadotropic function, deficient endogenous Gn-RH is replaced. An adequate dose of Gn-RH provided, which takes into account the degree of impairment of hypothalamic function in the individual case, follicular maturation, ovulation and corpus luteum formation are achieved in nearly every treatment cycle. The conception rate, which is, in addition to the treated dysfunction, also dependent upon other factors, is remarkably high as well.

Amenorrhea↗
PubMed1982

Inhibition of the renin--aldosterone axis and of prolactin secretion during pregnancy by L-dopa.

Recently, interactions between dopaminergic mechanisms and aldosterone secretion were described in non-pregnant subjects. The present study examined the effect of 1000 mg of L-dopa by mouth on plasma renin activity (PRA), and the concentrations of plasma aldosterone (PA) and prolactin (PRL) during normal pregnancy. Under basal conditions, there was a clear decrease of PRA, PA and PRL 60 min after oral intake of L-dopa in seven subjects; a further decrease was observed during the following 45 min, resulting in a total decrease of 41 (PRA), 44 (PA) and 56 (PRL) % of the respective arithmetic mean of the basal values. However, the response of PA to isopressor angiotensin II infusions was comparable before and shortly after treatment with L-dopa in 16 pregnant subjects. The decreased activity of the renin-aldosterone axis after administration of L-dopa may be attributed to an accumulation of dopamine and catecholamines in the brain, resulting in a diminution of sympathetic outflow from the central nervous system. The simultaneous and comparable changes of both PRA and PA after L-dopa treatment, as well as the reversibility of aldosterone suppression by infusion of angiotensin II, suggest that the inhibition of aldosterone secretion by L-dopa is mediated by a decrease of renin release.

Aldosterone↗
PubMed1982

Clinical, endocrinological, and cytological characterization of two 46, XX males.

In two 46,XX males, 20 and 21 yr of age, gonadotropins, testosterone, and estradiol were measured in serum and compared to those in a control group of four men. In addition, in one subject, androgen metabolism was measured in biopsied skin and cultured skin fibroblasts. In both XX men, a pulsatile pattern of gonadotropin, testosterone, and estradiol release into serum was observed. The levels of the gonadotropins and estradiol were higher and the levels of testosterone were lower in XX men than in normal men. hCG stimulation resulted in a significant increase in testosterone secretion, and LRH administration caused a more prolonged rise in gonadotropin levels in the XX men. The administration of estradiol caused a positive feedback response in the XX men and resulted in a suppression of gonadotropin secretion in the controls. Finally, the formations of C-19 metabolites from testosterone and estrone from androstenedione were found to be in the same range in skin and skin fibroblasts from the XX men as in those from normal men. It can be concluded that 46,XX men have altered hypothalamic-pituitary and gonadal function compared to normal men.

Adult↗
PubMed1981

Decrease of vascular angiotensin sensitivity by L-dopa during human pregnancy.

In 27 pregnant subjects (21 treated women and six control subjects), the effect of L-dopa (500 to 1,000 mg orally) on vascular sensitivity to angiotensin II amide (Hypertensin, Ciba) was examined in 16 of these women, 1,000 mg of L-dopa resulted in a significant decrease in vascular responsiveness to angiotensin, i.e., an increase in angiotensin pressor dose from 16.9 +/- 5.0 to 19.6 +/- 4.5 ng . kg-1 . min-1 (mean +/- SD). In women with an initially low angiotensin pressor dose, the changes were more pronounced. In six control subjects, in whom two angiotensin infusion tests were performed consecutively without additional administration of L-dopa, an increase in vasopressor response to angiotensin was demonstrated. Possible causes for the L-dopa-induced decrease in angiotensin sensitivity are discussed: an inhibition of sympathetic nervous activity, a directly lowered total peripheral resistance, a natriuresis and diuresis, and an altered dopaminergic activity in the hypothalamus. It is hypothesized that long-term treatment with L-dopa or bromocriptine might not only decrease angiotensin sensitivity but also elevated pregnancy-induced hypertension.

Angiotensin Amide↗
PubMed1981

Clinical significance of measurements of carcinoembryonic antigen in serum of patients with carcinoma of the uterine cervix.

Serum levels of carcinoembryonic antigen (CEA) were determined radioimmunologically before initiation of therapy in the serum of 88 patients suffering from carcinoma of the uterine cervix. The overall incidence of elevated CEA levels (above 12 ng/ml) was 43%. There was a positive correlation between the incidence of elevated CEA levels and the clinical stage of disease. CEA levels before treatment had no prognostic value as far as median survival time was concerned. In contrast, CEA levels measured immediately after therapy in patients with initially elevated levels turned out to be of prognostic significance. When the posttreatment concentrations of CEA were within the normal range, the median survival time was longer than 990 days (duration of follow-up). When the CEA levels remained elevated, however, the median survival time was only 291 days. Thus, CEA measurements appear to be an additional tool in the follow-up of

Adult↗
PubMed1980

Induction of ovulation with chronic intermittent (pulsatile) administration of LH-RH in women with hypothalamic and hyperprolactinemic amenorrhea.

Five women with hypothalamic amenorrhea were treated with LH-RH (10-15 microg i.v. at 90 min intervals for 17-20 days). In all women this chronic intermittent LH-RH administration resulted in a normalization of serum gonadotropin levels. Four women exhibited preovulatory estradiol serum levels with subsequent LH peaks. In three women the LH peaks were followed by normal luteal phase serum progesterone levels. One woman with hyperprolactinemic amenorrhea was also treated with the same therapeutic regimen which induced ovulation as judged from normal luteal phase serum progesterone levels. The results indicate that normal pituitary-ovarian function can be established in hypothalamic amenorrhea by chronic intermittent administration of LH-RH. They also suggest that in the human female hypothalamic LH-RH function may be only permissive in that the cyclicity of endocrine events during the menstrual cycle is regulated on pituitary and ovarian levels. Hyperproactinemic amenorrhea appears to be associated with insufficient endogenous LH-RH secretion which can be substituted by exogenous chronic intermittent administration of LH-RH. Elevated prolactin levels per se do not interfere with the pituitary positive feedback mechanisms nor with the gonadotropin action on the ovarian level.

Adult↗
PubMed1980

Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea.

In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by chronic intermittent (pulsatile) administration of Gn-RH. In order to apply chronic intermittent administration of Gn-RH as a new mode of treatment of infertility in hypothalamic amenorrhea on an outpatient basis a portable device ("Zyklomat") was constructed consisting of a peristaltic pump, a computerized timing device and a Gn-RH containing bag, which delivers 50 microliters of a Gn-RH containing solution once every 90 minutes via an i.v. catheter into the circulation. It is the purpose of this communication to present this new method of treatment and the successful induction of the first two pregnancies with this method in two patients with severe hypothalamic amenorrhea.

Adult↗
PubMed1980

LH-RH therapy in functional amenorrhea based on clinical subclassification.

The diagnostic approach to functional amenorrhea comprising a gestagen test, an LH-RH test, and the response to clomiphene as well as the recording of endogenous LH episodes allows a subclassification of the patients with regard to different therapeutic approaches. According to the degree of endogenous LH-RH deficiency, which is reflected by this diagnostic workup, a therapy with clomiphene alone, LH-RH combined with clomiphene, or LH-RH alone is effective. To avoid paradoxical effects any LH-RH substitution has to meet physiological conditions. Thus pulsatile and low-dose LH-RH administration of varied duration proved able to prime the hypothalamo-pituitary unit for either clomiphene or gonadal feedback signals resulting in ovulation and corpus luteum formation.

Amenorrhea↗