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Biomedical subjects

G Levy

Publications and source records attributed to G Levy.

At least 667 records · Page 37Linked to original sources
PubMedDate not supplied

Activation of the immune coagulation system by murine hepatitis virus strain 3.

Viral infections result in alterations in hemostasis and coagulation. It has previously been shown that susceptibility to murine hepatitis virus strain 3 (MHV-3), a coronavirus, correlates directly with the spontaneous, T lymphocyte-instructed expression of a procoagulant monokine that exhibits prothrombin-cleaving activity (procoagulant activity [PCA]). A biologic role for PCA in the pathogenesis of MHV-3 infection is suggested by results of in vivo microscopic observations made during acute MHV-3 infection. Recently, it has been demonstrated that prostaglandin E2 abrogates the induction of PCA by MHV-3 both in vivo and in vitro and prevents hepatic necrosis and the associated microcirculatory changes. These data suggest that MHV-3 induces cellular injury through the activation of the coagulation cascade and provide further evidence for a role for PCA in the pathogenesis of MHV-3 infection.

Animals↗
PubMedDate not supplied

[The value of velocimetric investigation of the uterine arteries in retro-placental hematoma. 3 cases].

Retro-placental hematoma is a sudden event with a serious prognosis which is aggravated by the very frequent absence of premonitory clinical, biological or ultrasonic signs. Does a velocimetric investigation of the uterine arteries have any predictive value in this disorder? The apparatus used was a continuous Doppler with spectral analysis and a 4 MHz probe no ultrasonic location. Each examination involved the exploration of 2 uterine arteries and of the umbilical flow. The method of recording the uterine arteries is described. Three cases of retro-placental hematoma are reported. In these three cases, an increase in the resistance index of one of the uterine arteries (the right artery in 2 cases and the left in 1 case) was detected with the presence of a protodiastolic notch on the trace, whereas the umbilical index itself was normal and no other sign was present which could predict the placental event. The value of the Doppler recording is already established in many obstetric indications, and these should be extended yet further, particularly if this preliminary study is confirmed on a larger scale.

Adult↗
PubMedDate not supplied

[Neonatal diagnosis of hypothyroidism by measurement of TSH levels: results in a series of 1880 cases from the University Hospital Center in Caen (author's transl)].

Early substitutive hormonal treatment for congenital hypothyroidism is the main factor affecting the prognosis of mental abnormalities. Therapy should be instituted in the first few weeks of life but clinical diagnosis is usually very difficult at this stage and biological criteria have to be used as a basis for establishing the diagnosis during the neonatal period. For this reason, TSH levels were measured in 1880 babies on the 4th day of life. This enabled a diagnosis of thyroid agenesia to be made in a case where no tangible clinical signs were present, and treatment could be started on the 12th day of life. Furthermore, two cases of hypothyroidism from iodine overdosage during amniography were discovered and early treatment instituted. The results of this study, which was limited to only one maternity unit, demonstrate the value of systematic diagnostic procedures for congenital hypothyroidism. It also underlines the danger of iodine overdosage during foetal life which could contra-indicate the use of amniography.

Congenital Hypothyroidism↗