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Biomedical subjects

G Leroy

Publications and source records attributed to G Leroy.

At least 91 records · Page 5Linked to original sources
PubMed1983

Automatic diluter for bacteriological samples.

The described apparatus, carrying 190 tubes, allows automatic and aseptic dilution of liquid or suspended-solid samples. Serial 10-fold dilutions are programmable from 10(-1) to 10(-9) and are carried out in glass tubes with screw caps and split silicone septa. Dilution assays performed with strains of Escherichia coli and Bacillus stearothermophilus permitted efficient conditions for sterilization of the needle to be defined and showed that the automatic dilutions were as accurate and as reproducible as the most rigorous conventional dilutions.

Bacteriological Techniques↗
PubMed1983

[Indication for and the future of valvular bioprosthesis].

Two fundamental characteristics distinguish bioprostheses from mechanical prostheses: disadvantage: reoperation inevitable after a variable delay; advantage: the problems of anticoagulation are avoided in the majority of cases and, above all, thromboembolic complications are reduced, thus improving the quality of life even if anticoagulation proves necessary. Before weighing up these considerations and making the difficult choice of the best prosthesis, two factors must be taken into account: the advances in cardiac surgery have enabled surgical therapy to be considered even in asymptomatic patients with the object of ensuring longer and better quality life; the concept of reoperation is still too often synonymous with surgical failure whilst thromboembolic complications are referred to fatality. To delay reoperation is to significantly increase the risks, so falsifying the statistical mortality rate and making it impossible to answer the fundamental question: "does the use of bioprostheses prolong life expectancy compared to mechanical prosthesis?".

Adult↗
PubMed1982

[Obstructive hypertrophic myocardiopathy and Osler's endocarditis].

Four cases of bacterial endocarditis (BE) complicating hypertrophic obstructive cardiomyopathy (HOCM) were observed between 1978 and 1980. The causal organism was a streptococcus in all cases and the portal of entry, dental. The mitral regurgitation (MR) observed in HOCM as an epiphenomenon of the obstruction became autonomous in 2 patients as shown by phonocardiography with methoxamine. In one case, the MR became severe and justified mitral valve replacement; at surgery, the chordal rupture suspected on echocardiography was confirmed. Antibiotic therapy was effective on the infectious process in all cases. However, 2 of the 4 patients died, one of thrombosis of the mitral prosthesis on the 15th postoperative day, and the other of a cerebrovascular accident. None of the patients had a detectable aortic or septal infectious lesion. Eight of 27 reported cases (30 p 100) of HOCM complicated by BE were operated; 10 (37 p. 100) died as a result of the endocarditis. These cases underline the incidence of BE in HOCM (5 p. 100) its gravity and the necessity for systematic antibiotic prophylaxis, especially before dental treatment.

Adult↗
PubMed1982

[Prevention of post-irradiation xerostomia by submaxillary gland transposition].

Transposition of the contralateral submaxillary gland to the submental region is proposed as a method for preventing asialia following salivary gland irradiation during radiotherapy for oropharyngeal cancer. Good results were obtained in the majority of cases treated, salivary secretion being conserved, as confirmed by scintigraphy, but the method should be reserved for patients with oropharyngeal cancer without lymph node metastases on the contralateral side.

Humans↗
PubMed1981

[Haemorrhagic necrosis of the digestive tract consecutive to massive digitalis intoxication (author's transl)].

A 60-year-old man under digitalis treatment for hypertensive heart tried to commit suicide by absorbing a 15 mg dose of digitoxin. Severe intestinal bleeding occurred 12 hours later, followed by pseudo-occlusive syndrome and ischaemia of the distal lower limbs. On abdominal incision the whole gut was found to be invaded by haemorrhagic necrosis and perforated on three points. The patients subsequently died of peritonitis. The responsibility of digitoxin in these events was demonstrated by the absence of any other cause of ischaemia, such as heart failure, shock, arrhythmia, consumption coagulopathy or use of sympathomimetic drugs. This case shows that the vasoconstrictor effect of digitalis, experimentally demonstrated but clinically controversial, is a reality, and that digitalis compounds are contra-indicated in patients with haemorrhagic necrosis of the digestive tract.

Digitalis Glycosides↗