Association of exposed Thomsen-Friedenreich antigen (T antigen) and acute renal failure in septic patients.
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Biomedical subjects
Publications and source records attributed to G Lenz.
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In 1980, two German Red Cross surgical teams served for 6 months at a field hospital in the Kampuchean Refugee Camp Khao I Dang in Thailand. The responsibilities of the two participating anesthesiologists, whose experience is reported in the present study, included anesthetic administration, resuscitation, triage, postoperative intensive care as well as consultations in nonsurgical emergencies and teaching programs. 40% of the 945 emergency operations were battle casualties. Since many patients were in poor condition before surgery, maintenance or restoration of vital functions was of prime importance, particularly shock therapy. Although local or regional anesthesia was preferred, general anesthesia was necessary in 568 cases (60%), with endotracheal intubation in 336 of these cases. Ketamine, generally combined with diazepam or flunitrazepam, proved advantageous for spontaneous respiration, assisted ventilation, and endotracheal anesthesia. Although the conditions were primitive, no fatal anesthetic complications were observed (surgical mortality rate, less than 2%).
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68 patients given an ICD (international classification of diseases) diagnosis of schizo-affective disorder during a hospitalization and consecutively treated in a lithium outpatient clinic were investigated. In a 'polydiagnostic approach' the overlaps and differences between different classificatory systems were assessed. A grouping of the patients according to a 'schizophrenic axial syndrome' with an emphasis on specific thought disorders showed significant differences between these groups in regard to the development of residual symptoms. Furthermore, a relationship between the absence of the schizophrenic axial syndrome and a good response to prophylactic lithium treatment was observed.
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A representative sample of patients under long-term lithium therapy was examined with respect to performance in reaction task, mood, and attitude toward lithium therapy. Reaction time to simple acoustic or visual stimuli as well as reactivity in complex settings under power- and speed-conditions requiring psychomotoric response represent the bulk of the data. Significant effects of additional medication, sex and duration of lithium therapy are assessed by univariate and multivariate data analysis. A hierarchic cluster analysis results in 5 well interpretable clusters. The clusters, furthermore, demonstrate the importance of attitude and other psychological variable, e.g. morning-/evening-type.
Spontaneous diabetes mellitus has been characterized in a line of nonobese purebred keeshond dogs as an insulin-requiring hereditary disorder with onset at between 2 and 6 mo of age. Diabetic dogs developed cataracts, became ketotic, hyperglycemic, hypercholesterolemic, lipemic, and hypoinsulinemic. Basal glucagon, cortisol, and T4 serum concentrations and responses to ACTH, TSH, and arginine were normal. Light microscopic studies of the pancreas by immunocytochemical procedures revealed the absence of islet B cells, the presence of A cells, and solitary B cells. Diabetic dogs had poor fecundity, and a single puberal diabetic male had poor semen quality and was unable to sire pups. Parents of diabetics and nondiabetic siblings were normal. This spontaneous form of diabetes mellitus, with similar lesions to the insulin-dependent diabetes of people, will be a valuable aid to comparative biomedical research of diabetes mellitus.
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A case is presented of lithium intoxication with therapeutic doses of lithium, owing to the additional administration of a sodium-excreting diuretic. Since the patient was receiving neuroleptic therapy at the same time, intoxication symptoms at the onset were falsely attributed to neuroleptic extrapyramidal effects. The possible effects of widely-used diuretics in conjunction with lithium therapy are presented. The combination of both therapeutic substances is possible, but calls for extreme caution and strict control of medication, diet and serum lithium levels.
From 1. 1. 1971--30. 6. 1977 (6.5 years) 4,169 aseptic orthopaedic operations were performed in the Orthopädische Universitätsklinik Düsseldorf. 42 complications of wound healing have been observed (1%)9 Without an ultrasteril operationbox it is also possible to reduce the complications of wound healing in orthopaedic surgery. It is important to know the principles of asepsis and antisepsis, the method of our preoperative preparation of patients is described; the indication of prophylaxis of chemotherapeutic agents should be severe.
Since 1969 all our patients below the age of three years, suffering from congenital luxation of the hip-joint, were treated conservatively. The "Extensions-reposition" and "Hanausekretention" were just slightly modified in providing the "Lorenzposition" by reducing the abduction. The rate of necrosis of the femoral head (4.3%) did not change significantly. In only one case we did not succeed in repositioning a completely luxated hipjoint conservatively. Children up to the age of 3 years can be treated conservatively by this method.
Since 1969 all our patients below the age of three years with congenital dislocation of the hip are treated by a modified overhead-traction (Extensionsreposition) and the "Hanausek-Apparat" for retention. Because of good results of careful reduction and retention in a mitigated Lorenz-position we also treated osteomyelitis of the hip-joint in newborns and following dislocation by this method. It is reported of 3 cases, different types of osteomyelitis of the hip and the method are described.
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The literature was surveyed concerning the frequency and conditions for confusional states and deliria following Amitriptyline and Clozapine treatment, and certain discrepancies were noted. As a result a retrospective comparative investigation was carried out as to the frequency and the conditions for such events in a group of patients treated along the same lines. While our experience with Amitriptyline is not different from that reported by others, this does not seem to be the case with Clozapine. Confusional states and deliria are four times as frequent as the average reported in the literature; it is clear that they depend on conditions different from those of confusional states and deliria due to Amitriptyline; there is a slightly significant (p less than 0.05) correlation between the appearance of confusion and a temperature of over 37.5 degrees C. The anticholinergic properties of Amitriptyline and of Clozapine cannot explain the difference in frequency, nor the differing conditions for the appearance, of pharmacogenic confusional states and deliria with those two substances.
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