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Biomedical subjects

G Krause

Publications and source records attributed to G Krause.

At least 145 records · Page 8Linked to original sources
PubMed1977

[Trial of piracetam in children with cerebral organic mental deficiency].

The administration, in a double blind experiment, of piracetam to two homogeneous groups of 32 and 34 eight- to twelve-year-old brain-injured special education children lacking normal mental ability, where the daily doses administered for a period of thirteen weeks were 3 tablets or 1.2 g (administered to second and third graders) and 5 tablets or 2.0 g (administered to fourth graders), respectively, did not produce a lasting effect upon the capacity to acquire and apply knowledge, the concentration power, the proficiency level, and the behavior shown by pupils during and out of school hours. On the other hand, there was observed, in patients receiving placebos, a nonsignificant tendency toward improvement in physical well-being, so that the effect produced by the drug may here be considered to be a negative one.

Attention↗
PubMed1976

A longitudinal study of total body potassium in normal breastfed and bottle-fed infants.

In a previous publication we predicted that growth as measured by 40K is best described by comparison of the semilog function of total body potassium (TBK) vs. length with a slope that differs in infants from that of children aged 3-18 years. Data for 84 infants having three or more measurements during the first year of life attest to this hypothesis, with a regression line for TBK and length: loge K, g = -0.265 + 0.04112 length in centimeters.

Adolescent↗
PubMed1976

Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.

A long-acting thymidine pellet consisting of 190 mg of cholesterol and 60 mg of thymidine has been developed for the study of thymidine metabolism and reutilization in vivo. Implantation of such a pellet s.c. in adult mice will maintain the blood plasma concentration of thymidine at levels between 40 and 8 X 10(-6) M, which are from 36 to 7 times those of normal mice, for periods up to 48 hr. During this period, in vivo uptake and reutilization of [125I]iododeoxyuridine, a thymidine analog, into intestinal and tumor DNA were almost completely suppressed. While iododeoxyuridine reutilization is not large in normal proliferative tissue even in the absence of pellet implants, reutilization of over 30% was measured in large, rapidly growing ascites tumors. The inhibition of iododeoxyuridine incorporation by elevated thymidine blood levels is directly proportional to serum concentration. This appears to be due to a thymidine pool in rapid equilibrium with blood thymidine. This pool is at least 10 times larger than the 4-nmole pool of extracellular thymidine.

Animals↗
PubMed1975

[Study on the effect of insulin on carbohydrate and lipid metabolism in obese subjects with normal glucose tolerance].

In altogether 32 test persons with normal weight and obese test persons glucose-insulin-tolerance-tests were carried out. In obese persons with normal carbohydrate tolerance -- characterized by 50 g oral glucose tolerance test -- by the decreased glucose assimilation coefficients and the significantly increased level of glycaemia after intravenous application of glucose a disturbance of the glucose-insulin-homoeostasis is already implied. Basal and glucose-stimulated concentrations of IRI in the peripheral venous blood were significantly increased in obese persons. The parameters of lipolysis glycerol and free fatty acids show after a glucose-stimulated insulin excretion and after exogenic insulin application a somewhat retarded decrease in obese persons compared with the control group. In connection with the significantly increased insulin levels in obese persons these findings might refer to a decreased antilipolytic effect of insulin. The two fundamental physiological effects of insulin in the carbohydrate and fat metabolism -- glucose utilization and inhibition of lipolysis -- seem to be distrubed in the same way in obesity.

Adult↗