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Biomedical subjects

G Judmaier

Publications and source records attributed to G Judmaier.

106 records · Page 6Linked to original sources
PubMed1983

[Ultrasound-assisted percutaneous blind puncture of the liver].

Since 1975 we performed 1221 percutaneous liver biopsies in outpatients. From 1978 onwards an upper abdominal ultrasound examination has been carried out in 731 patients before performing the puncture. In 203 consecutive punctures in the years 1981/82 another ultrasound examination two hours after the biopsy was performed. No complications have been observed. Hence, we recommend ultrasound examination in outpatients before biopsy for diagnostic and topographic reasons, but not afterwards, as the procedure seems reasonably safe.

Biopsy, Needle↗
PubMed1983

Primary hepatocellular carcinoma with hepatitis B virus infection in a 16-year-old noncirrhotic patient.

Primary hepatocellular carcinoma metastasizing to abdominal lymph nodes and to the left lung was observed in a 16-year-old male patient. No clinically apparent chronic liver disease preceded the carcinoma and no signs of cirrhosis were detectable in the nonneoplastic liver. Hepatitis B surface antigen, hepatitis B e antigen and antibody to hepatitis B core antigen were found to be positive in the serum. By immunohistochemistry (peroxidase-antiperoxidase technique) hepatitis B surface antigen could be demonstrated in the nontumorous liver parenchyma, but not in the primary hepatocellular carcinoma itself. Serum alpha-fetoprotein was only moderately elevated (75 ng/ml), but immunohistochemically primary hepatocellular carcinoma revealed a considerable number of alpha-fetoprotein-containing cells, whereas nontumorous parenchyma did not. Carcinoembryonic antigen could be demonstrated immunohistochemically in some tumor cells of a lymph node metastasis, but not in the primary tumor or in the nontumorous liver parenchyma. We propose that primary hepatocellular carcinoma developed in this case in a symptomless hepatitis B virus carrier without preceding cirrhosis, an we exclude a simultaneous acute hepatitis B.

Adolescent↗
PubMed1980

[Indications of laparoscopy in abdominal diseases (author's transl)].

On the basis of 900 laparoscopies it is attempted to define the indications of laparoscopy in abdominal diseases. 6 groups of indications could be differentiated. The diagnostic accuracy of laparoscopy allows in many cases to replace exploratory laparotomy by laparoscopy.

Appendicitis↗
PubMed1978

[Prognosis of acute viral hepatitis B (author's transl)].

Case reports of patients with acute viral hepatitis of the Medical Department of the Innsbruck University Medical School were evaluated in regard to prognosis. The following results were obtained: 1. Hepatitis B in the acute phase runs a severe course in more cases than non B hepatitis. 2. Disappearance of the HBs-antigen from the serum seems to be a reliable indicator for complete recovery; persistence of the antigen on the other hand indicates a chronic clinical course of the disease. 3. A difference in prognosis as to a chronic course of acute hepatitis B and non B hepatitis could not be found. Transition to a chronic stage seems to occur in about 3-15% of both forms of the disease together.

Adolescent↗
PubMedDate not supplied

Urinary neopterin levels in acute viral hepatitis.

Elevated neopterin levels in blood or urine have been shown to be a marker for the activation of cell-mediated immunity in vitro and in vivo. To evaluate whether neopterin levels are elevated in patients with acute viral hepatitis, we measured urinary levels in 13 patients with hepatitis A, 26 with hepatitis B, 12 with non-A, non-B hepatitis, 8 with jaundice and/or cholestasis due to biliary and pancreatic disorders and 3 with alcoholic hepatitis and in 62 apparently healthy HBsAg carriers. Neopterin levels in patients with virus-induced hepatitis were significantly higher than those in patients with other diagnoses. Urinary neopterin levels were above normal in 49 of 51 patients with viral hepatitis and elevations during the course of hepatitis showed a pattern similar to that of the usual liver biochemical tests, suggesting that neopterin levels were related to the clinical activity of the viral disease. In patients with nonviral biliary and hepatic disorders, neopterin levels were usually normal and did not correlate with other liver biochemical tests. These findings suggest that cell-mediated immune mechanisms are activated during viral hepatitis and that neopterin measurement may be of value as an additional surrogate marker for non-A, non-B hepatitis.

Acute Disease↗
PubMedDate not supplied

Alpha-1-antitrypsin deficiency and liver disease.

Alpha-1-antitrypsin deficiency is a common autosomal recessive disorder associated with premature development of emphysema, liver cirrhosis and hepatocellular carcinoma. This article reviews the existing literature on alpha-1-antitrypsin deficiency, with an emphasis on recent developments. A description of the protein, gene structure and function of alpha-1-antitrypsin as well as clinical aspects are presented. Treatment issues are addressed and a framework for the diagnostic workup and management of patients with alpha-1-antitrypsin deficiency and chronic liver disease is provided.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Primary hepatic tuberculosis in homozygous alpha-1-antitrypsin deficiency.

The case of a young female patient with homozygous alpha-1-antitrypsin deficiency (Pi-ZZ) associated chronic liver disease, who developed primary hepatic tuberculosis shortly after delivery of a healthy baby girl is reported. These findings emphasize that this rare disease should be considered even in patients with precirrhotic liver disease, while pointing out that the genetically determined deficiency of protease inhibitor alpha-1-antitrypsin (AAT) predisposes to hepatic infection.

Adult↗
PubMedDate not supplied

Differential diagnosis of malignant intrahepatic tumors by ultrasonically guided fine needle aspiration biopsy and by laparoscopic/intraoperative biopsy. A comparative study.

Thirty-six cases of ultrasonographically detected liver tumors (28 malignant and 8 benign lesions) were investigated by both fine needle aspiration (FNA) biopsy and laparoscopic or intraoperative tissue biopsy. The sensitivity of FNA biopsy in detecting a neoplasm was 85.7% while that of tissue biopsy was 82.1%. Specificity was 100% in both methods. A correct histologic diagnosis of the neoplasm could be made on the cytologic smear in only 14 cases (50.0%) due to technical and methodologic difficulties. Endoscopic and intraoperative tissue biopsy yielded sufficient material to make a definite histologic tumor diagnosis in 23 of 28 cases. Additional information on tumor spread and sequelae of liver infiltration was obtained by macroscopic tissue observations in nine cases. These results indicate that FNA biopsy is less sensitive in the classification of primary or secondary liver tumors and that tissue biopsies obtained during laparoscopy or laparotomy are required if a suspected hepatic neoplasm needs to be classified exactly to plan therapy and to establish a prognosis.

Adult↗