[Objective evaluation of the therapeutic effect of saline baths in patients with rheumatoid arthritis treated at the Goczałkowice Zdrój health resort].
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Biomedical subjects
Publications and source records attributed to G Jonderko.
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Investigations were carried out on two groups of patients suffering from cyclophrenia, atypical psychosis and schizophrenia. Both groups as well as a control group consisted of 30 persons each. The first of the psychiatric groups was treated with lithium carbonate and neuroleptics during a period of time ranging from 6 months to 8 years. The second psychiatric group was treated only with neuroleptics. The following parameters were being specified: The level of cortisol, insulin, somatotropin (GH) and lithium in the blood serum and also the glucose level in blood. Furthermore, the influence of lithium carbonate upon cortisol secretion and GH after insulin stimulation was also examined. The results of our work prove that the long-lasting treatment with lithium, when proper doses are carefully chosen, does not cause any significant changes of all the examined parameters.
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The examinations were performed on 3 groups of altogether 65 persons with thyreotoxicosis, the cause of which was either Basedow's disease or struma nodosa. The first group received metizol (thiamazol) in a daily dosage of 60 mg, the second group lithium carbonate (1.0 up to 1.5 g/a day), the third group metizol together with lithium carbonate. The groups were of the same value, concerning the degree of the symptoms of hyperthyroidism. The examinations showed that when lithium carbonate is used alone at the earliest a significant decrease of the serum T4 and T3 concentration as well as of the T3 binding index appears. After a treatment of seven days the therapeutic effects even up. Under the lithium therapy an essential improvement of the clinical findings was achieved. The combined therapy with lithium and metizol did not exhibit any advantages in this respect. The side-effects observed under the lithium therapy are no essential clinical problem.
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