Search PubMed⌕ Search

Biomedical subjects

G Jensen

Publications and source records attributed to G Jensen.

At least 181 records · Page 10Linked to original sources
PubMed1986

Acupuncture in severe, stable angina pectoris: a randomized trial.

Twenty-six patients with stable angina pectoris, resistant to medical treatment, were randomized to either active or sham acupuncture in a single-blind design. Sham acupuncture was defined as the insertion of needles in a point within the same spinal segments as the active acupuncture, but outside the Chinese meridian system. The effect was evaluated from anginal attack rate, nitroglycerin consumption and exercise tests. Compared to patients receiving sham acupuncture the patients receiving active acupuncture increased cardiac work capacity significantly, expressed as dPRP (difference in pressure-rate-product between rest and maximum exercise) and maximal PRP during exercise (p less than 0.001). None of the other variables showed any significant difference between the two groups. Concerning exercise tolerance the median difference was 138 Wmin (95% confidence limits - 12.5 to 325 Wmin), concerning anginal attack rate the median difference was 29.5% (95% confidence limits 55% to -11%) and with regard to nitroglycerin consumption the median difference was 5% (95% confidence limits +67% to -44%). No significant effect of sham treatment was observed, no adverse effect was observed. We suggest that acupuncture may improve cardiac work capacity in patients with angina pectoris, refractory to medical treatment.

Acupuncture Therapy↗
PubMed1985

Premature ventricular beats in healthy adult subjects 20 to 79 years of age.

111 healthy subjects, 57 males and 54 females, 20-79 years of age, randomly selected among the participants of the Copenhagen City Heart Study were tested for ventricular ectopic activity using ambulatory 24-h ECG recording. One or more premature ventricular beats (PVBs) appeared in 68 subjects (61%), 35 males and 33 females (61% of each group). The prevalence of PVBs increased significantly with age: 31, 68 and 84% in the respective age groups: 20-39, 40-59 and 60-79 (P less than 0.05). The number of PVBs per 24 h was less than 24 in 88 (79%), less than 300 in 105 (95%), and less than 500 in 107 (96%). More than 1000 PVBs per 24 h appeared in 3 (2.7%), one of whom had 11 669. The number of PVBs per 24 h increased with age, but the increase was not statistically significant. The number of PVBs per 100 000 recorded QRS-complexes did not differ significantly from the number of PVBs per 24 h. The number of PVBs h-1 was highest in daytime, and apparently higher in males than in females. However, the difference between the two sexes was not statistically significant. Multiform PVBs appeared in 4 subjects, interpolated PVBs in 2, a run of 5 PVBs in 1, dropped beats in 3, two pauses of 1900 ms duration in 1, and several post-acceleration pauses of 1300 ms duration in 1.

Adult↗
PubMed1985

Acute febrile neutrophilic dermatosis and abnormal bone marrow chromosomes as a marker for preleukemia.

Acute febrile neutrophilic dermatosis or Sweet's syndrome is a rare disease, which occasionally is seen in patients with myeloid leukemia. We present a case of Sweet's syndrome in a patient with an abnormal chromosome pattern in bone marrow aspirate. Initially the patient had flu-like symptoms with high fever. Two weeks later raised, erythematous and painful plaques appeared on the skin. Various antibiotics were ineffective, but the symptoms vanished after administration of prednisone. Six months later a fulminant acute myeloid leukemia developed, the course of which was complicated by a fatal subdural bleeding. It is concluded that Sweet's syndrome may be a cutaneous sign of a neoplastic myeloid proliferation and that a complete hematological examination including chromosome analysis is mandatory in these patients.

Acute Disease↗
PubMed1984

Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. II. Bone marrow cytology, cytogenetics, results of HLA typing, response to antileukemic chemotherapy, and survival in a total series of 55 patients.

Secondary acute nonlymphocytic leukemia or its earlier stages, preleukemia or an acute myeloproliferative syndrome with refractory cytopenia and clonal cytogenetic abnormalities of the bone marrow, was diagnosed in 55 patients previously treated for other malignant diseases. In patients with overt leukemia, cytologic, and cytochemical studies showed predominance of the French-American-British (FAB) type M2. Cytogenetic examination demonstrated a normal karyotype in 11 cases, whereas clonal abnormalities were observed in 44 patients. Defects of chromosome 7 were observed in 24 cases, most often -7, and defects of chromosome 5 in 14 cases, most often 5q-. In addition, chromosomes 3 and 17 were possibly nonrandomly involved. Other abnormalities commonly observed in de novo acute nonlymphocytic leukemia as t(8;21) and t(15;17) were not observed and +8 rarely seen in secondary leukemia. The survival from the leukemic complication was short for the whole group of 55 patients (median, 7 months). However, a significantly longer survival was observed in a subgroup of 11 patients with a normal karyotype (P less than 0.01), due to a favorable response to antileukemic chemotherapy, and in a subgroup of 11 patients with -7 or -C as the only cytogenetic abnormality (P less than 0.01), due to a prolonged preleukemic phase, compared with the remaining 33 cases with mostly multiple karyotypic abnormalities. Three preleukemic patients with -7 who were studied during transformation to overt leukemia all developed additional cytogenetic abnormalities. According to the two-step or multistep hypothesis for malignant transformation, the prolonged preleukemic course in patients with -7 as the only abnormality could represent a premalignant stage, in which further evolution is required for development of overt leukemia. The patients showed a random distribution of blood groups and HLA types.

Acute Disease↗
PubMed1984

Muscle strength and functional capacity in 78-81-year-old men and women.

Muscle strength was measured in 23 men and 29 women regarded as representative of the healthy urban population of about 80 years of age. Isometric and isokinetic-strengths of right knee-extension, plantar, and dorsal flexion, and the isometric strength of some upper extremity functions were measured. For knee-extension there was a decrease in strength of about 30% from the values in a population study of 70-year-old subjects ( Aniansson et al. 1980). Muscle strength was significantly lower in women than in men in all muscle groups except for plantar and dorsal flexion of the foot. Body cell mass was reduced compared to younger age groups by about the same extent as muscle strength, and correlated to knee-extension and hand grip strengths. Functional examinations such as step tests and walking tests were performed. A correlation between the results of these tests and muscle strength was not found except for knee-extension at 60 degrees/s in men. The rather low speed in comfortable walking (men 1.0 m X s-1, women 0.9 m X s-1) and the reduced capacity for step climbing diminish the possibility of using public transport and pedestrian street intersections in relatively healthy old people.

Aged↗
PubMed1984

Corporate benefit policies and health insurance costs.

We tested the hypothesis that health insurance premium costs per employee are lower for employee groups where multiple health plans are offered and the employer pays a level dollar amount of the chosen premium than for employee groups where these two conditions are not met. Proposed national legislation relies on these conditions to create a competitive health care market. Data on 56 employee groups in 1981 and 66 employee groups in 1982 were collected from two surveys of large employers in Minnesota. Regression analysis of premium data from both surveys rejected the hypothesis. Indemnity plans in multiplan groups were cheaper if the employer paid a level dollar contribution versus a level percent (including 100) contribution. However, groups offered only an indemnity plan had lower premiums than groups meeting the two legislative conditions. These findings apply to both individual and family coverage premiums and are not caused by systematic differences in benefit provisions, employee demographics or factors influencing loading charges. Our findings cast doubt on attempts to achieve health care competition by legislative changes in insurance options and contribution methods.

Deductibles and Coinsurance↗
PubMed1984

The cyclical behavior of hospital utilization and staffing.

Aggregate monthly data on hospital utilization and staffing are examined to assess the hospital industry's ability to adjust staffing levels to regular monthly cycles in demand. Graphical analysis and linear regression are used to assess the relationship between monthly trends in utilization and full-time-equivalent hospital personnel. We show that although regular seasonal patterns exist in both utilization and staffing levels, these series are largely independent of each other. The staffing level response to cycles in admissions and patient-days is, in fact, small relative to those observed for other industries that face predictable and regular fluctuations in product demand. Staffing levels appear to be more closely related to bed levels than to actual utilization levels. For a typical hospital which does not face effective incentives to control costs, smoother patterns of seasonal utilization probably will not result in lower staffing levels and reduced costs unless accompanied by a slowdown in the rate of increase in hospital bed size.

Economics, Hospital↗
PubMed1983

Haemodynamic and clinical effects of isosorbide-dinitrate in patients with severe effort angina on beta-blocking treatment.

The effect of isosorbide-dinitrate (ISDN) 20 mg 4 times daily against placebo has been tested in 12 patients with stable effort induced angina pectoris receiving prophylactic treatment with metoprolol. ISDN did not decrease the attack rate or nitroglycerine consumption, nor was exercise tolerance increased after it. Left ventricular function, assessed by radionuclide ventriculography, increased in 6 out of 8 patients (p less than 0.1). It is concluded that ISDN has no place in the treatment of haemodynamically intact patients with severe angina pectoris in spite of beta-blocking treatment, but that it may be of value in the treatment of patients with left ventricular failure, including those whose left ventricular failure has been brought about by beta-blocking treatment necessitated by angina pectoris.

Adult↗
PubMed1983

The determination of thyroid volume by ultrasound and its relationship to body weight, age, and sex in normal subjects.

Using a precise and accurate ultrasonic scanning technique we have measured the volume of the thyroid gland in vivo in 271 healthy subjects (13-91 yr old). In these subjects the mean (+/- SD) thyroid volume was 18.6 +/- 4.5 ml. A significant difference between males (19.6 +/- 4.7 ml; n = 139) and females (17.5 +/- 4.2 ml; n = 132) was found (P less than 0.001). The thyroid volume was significantly correlated with both body weight and age, described by: Y = 1.97 + 0.21 . x1 + 0.06 . x2, where Y is the thyroid volume (milliters), x1 is the body weight (kilograms), and x2 is the age (years). The influence of body weight on the thyroid volume was about 3 times that of age. The difference in thyroid gland volume between males and females was explained solely by a difference in body weight.

Adolescent↗