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Biomedical subjects

G Jackson

Publications and source records attributed to G Jackson.

At least 361 records · Page 20Linked to original sources
PubMed1975

Reassessment of failed beta-blocker treatment in angina pectoris by peak-exercise heart rate measurements.

Twenty-one patients with angina pectoris were treated with adrenergic beta-receptor antagonists. Previously the resting heart rate had been used as a guide to treatment, a reduction in the rate to 55-60 beats/min without symptomatic improvement indicating failure of medical treatment. These patients were re-evaluated before coronary arteriography using the peak-exercise heart rate as an index of adrenergic beta-receptor antagonism. The dose of beta-blocking drugs was increased to produce a peak-exercise heart rate of less than 100 beats/min or a consistent rate of 100-125 beats/min which would not lessen in spite of progressive dose increments. The resting heart rate was ignored. On these criteria 15 patients previously considered to have responded inadequately to beta-blockade responded satisfactorily and were therefore removed from the waiting list for coronary arteriography. They all remained well up to two years later. Six patients failed to respond and had coronary arteriography with a view to surgical treatment. Reliance on the resting heart rate as the index of optimum adrenergic beta-receptor antagonism is likely to lead to premature or unnecessary referral for surgery; the failure of beta-blockade in the treatment of angina pectoris can be determined simply and accurately by using peak-exercise heart rate.

Adrenergic beta-Antagonists↗
PubMed1975

Double-blind comparison of tolamolol, propranolol, practolol, and placebo in the treatment of angina pectoris.

Forty-two patients with angina pectoris have completed a randomized, double-blind trial comparing tolamolol 100 mg and 200 mg with propranolol 80 mg, practolol 100 mg, and placebo, all given three times a day. Tolamolol 200 mg thrice daily was found to be equivalent to propranolol 80 mg thrice daily in anti-anginal efficacy. Anginal attack rates and trinitrin consumption were significantly reduced by all active treatments as compared with the placebo but tolamolol and propranolol were the most effective. Tolamolol 200 mg thrice daily was most effective in reducing blood pressure, while propranolol was most effective in reducing the resting heart rate. All treatments except the placebo significantly increased the amount of exercise which could be performed before angina appeared (exercise work), while tolamolol 200 mg thrice daily significantly reduced Robinson's index when compared with all other active agents. The degree of S-T segment depression induced by exercise was significantly lessened by both tolamolol and propranolol but not by practolol or placebo. There was no difference in patient preference between tolamolol and propranolol but tolamolol at both dose levels was preferred to practolol. Both tolamolol and propranolol are potent adrenergic beta-receptor antagonists and equal in anti-anginal efficacy but tolamolol has the advantage of being cardioselective. It is superior to practolol.

Adult↗
PubMed1973

Child injury intensive monitoring system.

A system for the acquisition and recording of child injuries is described. This computer-based system is designed for implementation in three stages. Each successive stage covers wider geographical areas and provides more comprehensive facilities.Stage 1 collects basic identification information on injured children. It provides an intensive monitoring service which alerts the agencies properly concerned with child abuse to repeated or suspicious injury cases. Misleading or suppressed information increases rather than limits the precision of diagnosis. More comprehensive details of those children thought to be at risk are collected when stage 2 is introduced. The printed results of the processing of these details are circulated to certain authorized users, and they are organized for rapid information retrieval. A central office which receives a weekly copy of this cross-referenced file provides a 24-hour information service.In stage 3 a register containing fully structured, standardized case reports will be established. We believe that this system ensures medical confidentiality and respects the rights of parents and children.

Child↗
PubMed1972

Child abuse syndrome: the cases we miss.

One hundred cases of physical injury to children are reviewed. Eighteen cases are shown to be misdiagnosed cases of child abuse. It is suggested that all hospitals review their records of childhood trauma in the light of these findings. All children under 4 years of age with trauma of non-obvious aetiology should be referred to the paediatrician.

Accidents, Home↗
PubMed1972

Hyaluronate in morphogenesis: inhibition of chondrogenesis in vitro.

Purified hyaluronate, at a concentration as low as 1 ng/ml, blocks the formation of colonies and cartilage nodules in stationary cultures of cells, isolated by treatment with trypsin, from embryonic chick somites and limb buds. This phenomenon in vitro is correlated with sequences of hyaluronate production and hyaluronidase activity during chondrogenesis in embryonic and regenerating tissues in vivo. An hypothesis is proposed in which hyaluronate acts as a regulator or inhibitor of mesenchymal cell aggregation in embryogenesis, its synthesis and removal being part of the mechanism of timing of migration, aggregation, and subsequent differentiation.

Animals↗