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Biomedical subjects

G Irie

Publications and source records attributed to G Irie.

At least 55 records · Page 3Linked to original sources
PubMed1988

[An analysis of needle biopsy under ultrasonography of the thyroid gland].

A multivariate analysis of 47 thyroid nodules and 34 diffuse goiters has been employed to determine the cause of failure in thyroid biopsy under ultrasonography. In the thyroid nodule cases, 30 percent were found to have been misdiagnosed or judged to be an inappropriate sampling. The most important factor leading to failure is a size of tumor. Only one fourth of the small tumors of less than 1 cm were correctly diagnosed and, in cases of a relatively large cystic tumor or a peripherally located nodule, an exact diagnosis was difficult, though 90 percent of the diffuse goiters were difficult, though 90 percent of the diffuse goiters were correctly diagnosed by this method. This result indicates that needle biopsy of the thyroid gland is reliable in cases of a diffuse goiter but problems remain to be resolved in cases of small or cystic tumors and peripherally located nodules.

Adolescent↗
PubMed1987

[Combined chemotherapy and radiotherapy in recurrent tumors of the head and neck region].

Over the past four years, 27 patients with recurrent tumors of the head and neck region have been treated with chemotherapy. The regimens used were BCMF (bleomycin 15 mg i.v. for 3 days, cyclophosphamide 500 mg i.v., methotrexate 50 mg i.v. and 5-fluorouracil 500 mg i.v.) and CMU (cyclophosphamide 350 mg/m2 i.v., methotrexate 30 mg/m2 i.v. and UFT 600 mg p.o. for 14 days). Of the 27 patients, eight were treated with combined radiation and chemotherapy, and either CR or PR was obtained. Nineteen patients were treated with chemotherapy alone, for which the response (CR + PR) rates were 8% (1/12) for BCMF and 43% (3/7) for CMU, respectively. No serious toxicities were observed as a result of these regimens. It was thus demonstrated that the CMU regimen was of great value in terms of improved response and minor toxicity in the treatment of head and neck tumors.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Interstitial irradiation by 192Ir seed assemblies in fixed cervical lymph node metastases].

Eleven patients with fixed cervical lymph node metastases were treated using external irradiation followed by interstitial implants, 137Cs needles were used for one patient and 192Ir seed-assemblies for 10 patients. The local tumor responses were 4 CR, 6 PR and 1 NC. Acute tolerance was good, and there were no major late injuries except for one case of severe subcutaneous fibrosis. No morbidities such as local infection, bleeding or pulmonary injuries were encountered. Clear-cut dose control relationships were demonstrated; the local control of the nodes treated with intervals of more than one month between external and interstitial irradiation was poor. It is considered that adequate treatment is to give 40 Gy over 4 weeks by external irradiation first, then, after an interval of 2 weeks, to give 40-50 Gy over 4-5 days using 192Ir interstitial implants. The interstitial implants appeared to provide an improvement in local control and in the therapeutic ratio of fixed cervical lymph node metastases.

Aged↗
PubMed1987

[Contribution of CT and MRI to radiation therapy].

The contribution of CT to radiation therapy has been enormous. The most basic contribution has been that CT has made almost all malignant tumors visible, which has improved radiation therapy not only in the planning phase but also in the effect-estimating phase. As some examples, CT has improved the effects of radiation therapy for cancer of the maxillary sinus and of the uterine cervix, and the results from our department have already been published. The contribution of MRI to radiation therapy should be very great in future wherever MRI diagnostics are established. Even now, however, its ability to visualize cross-sectional anatomy in any area is an aid to radiation therapy both in planning and in estimating the degree of effect.

Brachytherapy↗
PubMed1986

Early stage head and neck non-Hodgkin's lymphoma. The effect of tumor burden on prognosis.

Treatment results were investigated in 113 previously untreated patients with clinical Stage I and II (Ann Arbor) non-Hodgkin's lymphoma of the head and neck. Fifty-six Waldeyer's ring, 34 other extranodal sites, and 23 cervical nodal lesions were included. The overall relapse-free survival at 5 years was 41%. Age and Ann Arbor stage influenced relapse-free survival. The results suggested that the tumor cell burden is a fundamental prognostic factor for patients with Waldeyer's ring disease and for patients with only cervical nodal disease. Abdominal relapse was most frequent, followed by generalized relapse. From 1981, patients were randomized in a clinical trial to receive either chemotherapy (cyclophosphamide, vincristine, and prednisone [CVP], five courses) or whole-abdominal irradiation (25 Gy/20 Fr) as an adjuvant therapy. Patients could not tolerate the whole-abdominal irradiation well. A significant improvement in survival has been obtained by adjuvant chemotherapy.

Adolescent↗
PubMed1986

The role of radiotherapy in the management of maxillary sinus carcinoma.

From 1971 to 1983, a total of 208 patients with maxillary sinus carcinomas were treated at Department of Radiology, Hokkaido University School of Medicine, 38 by Method I (radiation + surgery + intraarterial 5-fluorouracil [5-Fu] infusion), and 170 by Method II (radiation + surgery). Radiation doses ranged from 30 to 50 Gy over 3 to 5 weeks in Method I and 52 to 58 Gy over 4 weeks in Method II. Overall actuarial survival rate at 5 years was 45.6%. No statistical difference in survival rates was found between Method I and Method II. With respect to T stage, absolute 5-year survival rates were 100% (4/4) for T2, 49.5% (52/105) for T3, and 24.4% (11/45) for T4. From our data, no advantage in the use of intra-arterial 5-Fu infusion was demonstrated; the local failures in Method I developed earlier and more frequently than in Method II. The ultimate failures for all patients were 46.8%. Since 1980 when treatment planning by using computerized tomography scans and immobilization device was initiated, improvement in survival rate while reducing an incidence of eye complications has been accomplished.

Adult↗