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Biomedical subjects

G Holland

Publications and source records attributed to G Holland.

At least 37 records · Page 2Linked to original sources
PubMed1986

Indapamide. Effects on apoprotein, lipoprotein, and glucoregulation in ambulatory diabetic patients.

We evaluated the long-term effects of indapamide, a non-thiazide diuretic, on blood pressure, glucoregulation, free insulin and C-peptide levels, and lipoprotein and apoprotein metabolism in 13 hypertensive diabetic patients for 24 weeks. Indapamide significantly reduced both systolic and diastolic blood pressure by 15% and 17%, respectively. Both mean fasting serum glucose and integrated glucose responses after oral glucose load (75 g) were significantly higher during indapamide therapy than at week 0. The mean fasting and stimulated C-peptide responses were significantly increased despite worsening glucose control. At the end of 24 weeks, mean glycosylated hemoglobin level had increased significantly. Indapamide caused a slight but insignificant rise in the total triglyceride, cholesterol, and low-density lipoprotein cholesterol levels, while the high-density lipoprotein cholesterol level decreased. In addition, the apoprotein A-1 concentrations remained unchanged while the apoprotein B-100 level decreased. Apart from hypokalemia (less than 3.5 mEq/L [less than 3.5 mmol/L]) in three patients that required oral potassium supplementation, biochemical changes were of no clinical consequence.

Adult↗
PubMed1983

[Clinical experience with iridencleisis].

The authors report on 120 patients who underwent iridencleisis (155 eyes). Of these, 36 had open-angle glaucoma, 26 congestive glaucoma and 54 were suffering from acute glaucoma of long standing. Two patients had exfoliation syndrome and two, secondary glaucoma. The kind of filtration bleb, postoperative complications such as flat anterior chamber or loss of anterior chamber, hyphema, choroidal detachment and postoperative and final regulation of IOP are discussed in detail. Since 1975, the authors have preferred Fronimopoulos' method of goniotrepanation to iridencleisis for treating open-angle and congestive glaucoma. However, in cases of protracted, uninterrupted acute glaucoma iridencleisis can still be recommended as a dependable procedure.

Aged↗
PubMed1978

The effects of 11-methyl 16,16 dimethyl prostaglandin E2 on canine gastric acid secretion.

11-Methyl 16,16 dimethyl Prostaglandin E2 (TM-PGE2) at peak effectiveness inhibited acid output stimulated submaximally by histamine in the dog by 95 and 84% when administered by the intravenous and oral routes, respectively. Inhibition of secretion was maintained for 1-1/2 hours following intravenous administration while with the oral route, secretory inhibition was still present at the end of two hours after administration of the drug. The degree of inhibition of acid secretion caused by TM-PGE2, its duration of action and the lack of side effects observed following administration of this drug makes it a suitable compound for evaluation as an anti-secretory agent in man.

Administration, Oral↗