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Biomedical subjects

G Hein

Publications and source records attributed to G Hein.

At least 109 records · Page 6Linked to original sources

[Physical therapy in inflammatory rheumatic diseases].

The physiotherapy of inflammatory rheumatic diseases is interpreted at the instance of the clinical pictures of rheumatoid arthritis, ankylosing spondylitis and progressive sclerodermia. Issuing from the clinical picture in each case the aim of therapy and the application of physiotherapy are described. For practice it is particularly referred to the significance of the temporary phases of the disease with regard to therapeutic purpose and planning of physiotherapy.

Arthritis, Rheumatoid↗

Antiasthmatic effects of onions. Inhibition of platelet-activating factor-induced bronchial obstruction by onion oils.

Lyophilized onion extract and ether extracts of onions were separated by chromatographic methods into several subfractions and tested for their effects on asthmatic reactions of guinea pigs to allergen, histamine, acetylcholine and platelet-activating factor (PAF) inhalation as well as on thromboxane biosynthesis of human platelets and lung fibroblasts. Onion oils are counteracting the bronchial obstruction due to PAF inhalation.

Allium↗

[The quantitative determination of the IgM rheumatoid factor using a solid-phase radioimmunoassay. Comparison with the agglutination test and the radioimmuno-polyethyleneglycol precipitation test].

A solid-phase radioimmunoassay capable of detecting nanogram quantities of human IgM rheumatoid factor using a monoclonal anti-mu-chain antibody is described. Human IgG did not interfere with the detection of IgM RF by this method. The small nonspecific binding of nonRF IgM to the human IgG coated tubes utilized in the assay must be corrected for by assaying samples in parallel bovine serum albumin coated control tubes only in cases of deviation of IgM from normal range. 69 coded and randomly arranged sera from patients with rheumatoid arthritis (RA), nonrheumatic joint diseases and healthy adult control subjects were investigated by this method, agglutination techniques as well as RIPEGA. A good correlation between solid-phase radioimmunoassay and agglutination techniques was found. Patients with seropositive RA had significantly higher concentrations of IgM RF than seronegative RA patients or control subjects (mean +/- 1 SD = 133,3 +/- 187,2 micrograms/ml versus 4,7 +/- 6,5 micrograms/ml and 2,2 +/- 4,0 micrograms/ml; resp.).

Agglutination Tests↗

[Etiopathogenetic aspects of psoriatic arthritis with special reference to immunologic factors].

On 21 patients with psoriasis and 22 with psoriatric arthritis examinations for the recognition of the immune regulation were performed and the results were compared with those of healthy control persons and patients with rheumatoid arthritis. The psoriatric arthritis shows humoral as well as cellular disturbances of immune regulations which in the group comparison with the psoriasis and the rheumatoid arthritis partly have communities, but partly also have differences. With regard to size and distinction of the disturbances the patients with rheumatoid arthritis have the highest degree of severity. With the help of the techniques used by us systemic cellular disturbances of the immune regulations could not be proved in the psoriasis. The psoriatic arthritis to a certain extent occupies a medium position. But a clear coordination of these disturbances into the pathogenetic process is not yet possible.

Antibodies, Antinuclear↗

[Lymphocyte subpopulations in psoriatic arthritis].

17 and 20 patients, respectively, with psoriasis-arthritis were examined by means of the SE-, ME-, EA- and stable rosette test and the results were compared with the results in healthy control persons. In these cases in the patients with psoriasis-arthritis a significant increase of the B-cells carrying the ME-receptor was objectified. This result is explained in the sense of an antigen-stimulation.

Adult↗

[Thyroid autoantibodies in diabetes mellitus and rheumatoid arthritis].

In 58 patients with rheumatoid arthritis and 101 patients with diabetes mellitus (type I) microsomal antibodies of the thyroid gland as well as antinuclear factors were determined and their frequency was compared with the frequency in test persons with hyperthyroidism, bland struma and a control group. Only in diabetes mellitus with 13% an increased presence of humoral sensitization of the thyroid gland was found, whereas relevant to this no considerable differences were present between rheumatoid arthritis (5%), bland struma (5%) and controls (4%). As we expected the frequency of antibodies was high with 74% in the diffuse hyperthyroidism. In patients with rheumatism antinuclear factors were increasedly found only in higher degrees of titres. Though the determination of microsomal autoantibodies is only one parameter in the immunological diagnosis of the thyroid gland, it seems that according to our investigations a Hashimoto-thyroidism in rheumatoid arthritis does not increasedly occur. Overlapping immune reactions were found only among presumable autoimmunoendocrinopathies. The thesis of the preferred combination of autoimmune sensitization among the groups with organ-specific or organ-unspecific antigens is supported according to the present findings. The insignificant appearance of thyroid autoantibodies in the bland struma refers to the fact that in the endemic area immunomechanisms play an inferior role for the development of struma.

Antibodies, Antinuclear↗

[Bone mineral content determination by the photon absorption technic in chronic non-occupational fluoride exposure].

Bone mineral content and bone width of radius were examined by use of bone mineral analyser in persons with long-term nonoccupational fluoride exposition. Investigations took place in 275 female and 194 male without professional fluoride influence. Comparison with normal values showed no significant differences after fluoride exposition. The meaning of these findings is discussed.

Adolescent↗

[Intra-articular therapy with radionuclides].

The 12-year experiences of a working team with the intraarticular radiogold therapy in persisting synovialitides of chronic rheumatic diseases and resistant irritation phases of arthroses are supplementarily described and a critical valuation is performed. Finally practical conclusions for the local joint therapy are made, taking into consideration also the experiences of other investigators.

Adult↗

[Caries or fluoridation--a comparison between Hamburg and Vordingborg (Denmark)].

The struggle against caries and their consequences calls for continuing and considerable financial support by governments. The exact extent of caries incidence is evident in official statistics on Hamburg school children. Childhood caries leading to the physiologically damaging, premature loss of deciduous teeth often causes subsequent malocclusion of the remaining teeth, thereby requiring costly, time-consuming orthodontic treatment. The endogenous and exogenous effects of fluorides on the developing or mature hard tissues of the dentition can significantly reduce the incidence of caries. These caries-inhibiting properties can be mostly clearly seen in the example of Vordingborg (Denmark), where naturally occurring drinking water has a fluoride content of between 1.3 and 1.7 parts per million. Comparisons have shown that despite absolutely equivalent conditions, including identical school dental care, the incidence of caries among Vordingborg children is nevertheless only a third of that in parallel groups from Roskilde, where the fluoride content of drinking water is only 0;1 to 0.3 parts per million.

Adolescent↗