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Biomedical subjects

G Hartwich

Publications and source records attributed to G Hartwich.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Disaccharidases of the small-intestinal mucosa of the rat under therapy with ifosfamide (author's transl)].

In rats, treatment with 3-(2-chloroethyl)-2-(2-chloroethyl-amino)-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide (ifosfamide; Asta Z 4942) results in a decrease of intestinal disaccharidase activities concomitant with morphological alterations of the mucosa. Even after morphological restoration of the tissue, enzyme activities remain reduced for a couple of days. Examinations of patients treated with ifosfamide will show whether there are comparable effects also in man which may lead to malabsorption of disaccharidases.

Animals↗
PubMed1976

[Disaccharidases of the intestinal mucosa of the rat after cytostatic combined therapy with vincristin sulphate and ifosfamide (author's transl)].

Vincristin sulphate or 3-(2-chloroethyl)-2-(2-chloroethyl-amino)-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide (ifosfamide)--given alone--may reduce intestinal disaccharidase activities in the rat. However, combined administration of both the drugs, as used as a therapeutic means, results in a much more drastic decrease in enzyme activities. Consequently, also in man maldigestion of disaccharides might occur due to that polychemotherapy.

Animals↗
PubMed1975

[Co-existence of chronic myeloid leukaemia and carcinoma of the breast (author's transl)].

Chronic myeloid leukaemia and carcinoma of the breast co-existed in three women. This combination is exceedingly rare. Although the cancerogenic properties of ionizing radiation and cytostatic drugs could be held responsible for the occurrence of two malignant tumours, no definitive conclusions can be drawn in the individual case. Co-existence of leukaemia and carcinoma does not occur more frequently than could be predicted statistically from the incidence of each.

Aged↗
PubMed1975

[Thrombocythaemia - is there a primary form? ((author's transl)].

Within 5 years 11 patients with thrombocythaemia were admitted to the Department of Internal Medicine, University of Erlangen-Nuremberg. All cases were secondary forms in the course of other myelo-proliferative disorders. In one patient thrombocythaemia preceded the primary disorder for some time. There are some doubts whether the primary form of thrombocythaemia is an entity sui generis.

Adult↗
PubMed1975

Disaccharidases in rat small intestinal mucosa following cytostatic treatment with adriamycin.

Our studies have shown that appropriate doses of adriamycin can reduce the activities of the intestinal disaccharidases in the rat. At higher doses, in addition to morphological changes in the intestinal mucosa, a considerable fall in disaccharidase activities also occurs. This functional impairment can be seen for a period of several days after the morphological restitution of the mucosa. Appropriate studies of the small intestinal mucosa in man will have to be undertaken to show whether similar impairment occurs at therapeutic doses.

Animals↗
PubMed1975

[Exploratory laparotomy and splenectomy in lymphogranulomatosis (author's transl)].

Exact determination of the extent of the disease is necessary for optimal treatment of lymphogranulomatosis. To this purpose 53 patients with lymphogranulomatosis had an exploratory laparotomy and splenectomy (42 adults and 11 children). On the basis of the operation results the pre-operative staging had to be revised in 14 patients and the treatment plan had to be changed in most cases. Lymphogranulomatosis of the spleen was demonstrable in 27 cases. Histologically the mixed-cell type was most commonly seen in the spleen. The size of the spleen was an unreliable diagnostic parameter as regards involvement with lymphogranulomatosis. In approximately a third of the adults with involved spleens the weight of the spleen was under 200 g. Hodgkin involvement of the liver was demonstrable in three patients; in these three cases splenic involvement coexisted. In seven patients post-operative complications occurred.

Adolescent↗
PubMed1975

[Results of therapy in acute leukemia in adults. Comparison of different combinations of cytotoxic drugs].

In 67 patients with acute leukemia 76 treatment-series were performed which were analyzed to evaluate whether chemotherapy has brought some progress during the past years. With 67 sufficient treatments a total of 26 remissions were achieved. VIDaP-scheme with 43 p.c. and cytosinarabinosid with 46 p.c. were significantly superior to the older scheme methotrexat-purinethol-prednisone with only 29 p.c. remissions. A remarkable deterioration of prognosis with increasing age rises the question whether treatment with cytotoxic drugs should be tried in patients more than 60 years old. Remission rate in patients below 20 was especially high with 71 p.c. so that the well-known good prognosis of juvenile leukemia can be extended with some limitations until age 20.

Acute Disease↗
PubMed1975

[Influence of cytostatic combination therapy with vincristine sulphate and iphosphamide on blood coagulation].

Disorders of blood coagulation were investigated before and during a cytostatic combination therapy with vincristine sulphate and iphosphamide (Asta Z 4942) in 12 patients with malignant tumours or haemoblastoses. Thromboplastin time, partial thromboplastin time, thrombin time, heat-dependent fibrin, clot retraction, and clotting factors II, V, VIII, IX, X, and the platelet count were determined. A change in the plasmatic coagulation system attributable to the combination therapy could not be demonstrated in any patient. The influence of the cytostatic combination on the platelet-dependent haemostasis was small; a decrease in platelet count could be observed in only one patient, in whom an additional causative damage to thrombopoiesis due to the underlying disease could be assumed. Regardless of the cytostatic therapy there were indications of a hypercoagulability in 10 patients. This explains the increased susceptibility of such patients for thromboses or consumption coagulopathy.

Adult↗
PubMed1975

[Clusters of Hodgkin's disease. Case report of two brothers].

Case report of two brothers who suffered from lymphogranulomatosis successively. Familiary clusters are rare and are in favour of infectious and of hereditary factors in the pathogenesis of Hodgkin's disease. The own observation is discussed in reference to the world literature.

Adolescent↗
PubMed1975

[Unusual clinical course of malignant lymphoma(author's transl)].

Primary malignant lymphoma of the gastrointestinal tract and intestinal involvement in diffuse lymphoproliferative diseases are far more common than generally believed. A typical clinical course of these disorders may rose considerable diagnostic problems. Scirrhous growth patterns, diffuse gastrointestinal polyposis and multiple colonic ulcers are presented as rare variants of malignant lymphoma of the digestive tract.

Adult↗