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Biomedical subjects

G Hansson

Publications and source records attributed to G Hansson.

130 records · Page 8Linked to original sources

Intact brain serotonin system in vascular dementia.

Pre- and postsynaptic elements of the 5-hydroxytryptamine (5-HT, serotonin) system were studied in a control group and in patients with vascular dementia (VAD). The 5-HT uptake site was used as a presynaptic marker for 5-HT terminals and 5-HT1A and 5HT2 receptors were used as postsynaptic markers. The binding sites were quantified with radioligand binding techniques, where the radioligands used were [3H]paroxetine, [3H]8-OH-DPAT and [3H]ketanserin, respectively. The presynaptic uptake site was studied in frontal and temporal cortices and caudate nucleus. 5-HT1A and 5-HT2 receptors were studied only in frontal and temporal cortices. There were no differences between control and VAD groups in any of the regions investigated with respect to the number of binding sites (Bmax) and binding affinity (Kd). This indicates that both pre- and postsynaptic parts of the 5-HT system are intact in these brain areas in VAD.

8-Hydroxy-2-(di-n-propylamino)tetralin↗

The Swedish experience with Salter's innominate osteotomy in the treatment of congenital subluxation and dislocation of the hip.

The results of 83 Salter's innominate osteotomies (i.o.) performed to correct congenital subluxation and dislocation of the hip joint in 76 patients were reviewed. The overall radiographic results were classified as excellent or good in 34 hips (41%) and as fair or failure in 49 hips (59%). The best results were obtained in subluxated hips, previously not treated or treated only with closed reduction, prior to i.o. in patients operated on before the age of 5 years. In that group of hips, excellent or good results were obtained in 18 of 20 hips (90%). The poorest results were obtained in hips with residual subluxation or dislocation after previous operation with a result of fair or failure obtained in 26 of 28 hips (93%).

Adolescent↗

Innominate osteotomy in the management of residual congenital subluxation of the hip in young adults.

The application of innominate osteotomy (IO) to persistent subluxation of the hip in adults is limited. Indeed, a relatively small percentage of such adults, particularly those in the fourth and fifth decades of life, meet the precise indications and essential prerequisites for IO. Nevertheless, in most carefully selected young adults in up to and including the fifth decade of life, IO has proved successful. The objective of IO is to prevent degenerative processes in adults with only potential arthritis, seeking arrest or even reversal of the progression of degenerative disease. IO is applicable only to adults who have arthritis in its earliest stages. Achievement of these objectives is dependent on adherence to the exact indications, prerequisites, and contraindications as well as to the details of the surgical technique as described.

Adolescent↗