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Biomedical subjects

G Hansson

Publications and source records attributed to G Hansson.

At least 109 records · Page 6Linked to original sources
PubMed1981

Radiation-induced parathyroid adenomas and thyroid tumors in rats.

Parathyroid morphology was studied in 45 irradiated and 37 control rats. The irradiated rats received a single parathyroid dose of about 6.5 gray. The rats were killed and autopsied 14 months later. The radiation resulted in fibrosis and depression in weight of the parathyroids. In irradiated rats eleven parathyroid adenomas and four thyroid tumors were found. In control rats no tumor occurred in either parathyroid or thyroid glands. All irradiated rats, including those with a parathyroid adenoma, were normocalcemic.

Adenoma↗
PubMed1980

Chemical instability of 15-keto-13,14-dihydro-PGE2: the reason for low assay reliability.

The spontaneous degradation of 15-keto-13,14-dihydro-PGE2 was studied under various conditions. In aqueous media, dehydration rapidly occurred, particularly at high or very low pH. The acid catalyzed dehydration product was identified as 15-keto-13,14-dihydro-PGA2. This compound was also formed at alkaline pH, however, at higher pH a bicyclic compound, 11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-PGE2, was formed in addition (cf. Fig. 1). The amounts of the latter compound increased with time and with increasing pH. In samples containing albumin, 15-keto-dihydro-PGE2 was degraded even more rapidly than in buffer of the same pH. In addition to the formation of the dehydration products, a considerable part of the metabolite was bound to albumin to yield water soluble adducts. A similar binding occurred to a low molecular weight fraction of plasma. The compound that was bound was 15-keto-dihydro-PGA2, whereas both 15-keto-dihydro-PGE2 and the bicyclic product were relatively inert in this respect. Due to its chemical stability, the bicyclic degradation product, 11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-PGE2, is suggested as a suitable target for measurements instead of the labile parent compound, 15-keto-dihydro-PGE2, or the reactive dehydration product, 15-keto-dihydro-PGA2.

Acids↗
PubMed1980

Gastric and intestinal mucosal morphology before and after interposition of a reflux-preventing valve between the gastric remnant and the duodenum. An experimental study in dogs.

A gastric mucosal reaction characterized by inflammatory cells and oedema in the lamina propria and proliferation of surface epithelium was found in 5 out of 12 dogs subjected to partial gastrectomy and examined 1-6 months after the operation. A normal gastric mucosa was found in 14 dogs 1-12 months after interposition of a reflux-preventing valve between the gastric remnant and the duodenum. In 4 dogs with histologically verified gastritis after partial gastrectomy, transposition of a jejunal segment provided with an intussusception valve resulted in normalization of the gastric mucosal morphology.

Animals↗
PubMed1979

Metabolism of two PGF2 alpha analogues in primates: 15(S)-15-methyl-delta 4-cis-PGF1 alpha and 16,16-dimethyl-delta 4-cis-PGF1 alpha.

The metabolism of the prostaglandin F2 alpha analogues, 15-methyl-delta 4-cis-PGF1 alpha and 16,16-dimethyl-delta 4-cis-PGF1 alpha, has been investigated in the cynomologus monkey and the human female. The two analogues, tritium labelled in the 9 beta-position, were administered by intramuscular injections into the monkeys and by subcutaneous injections into the human. Excretion of tritium labelled products were followed in urine (in both species) and feces (in monkeys only) and several metabolites were identified by GC/MS. The analogues were found to be resistant to the 15-hydroxy dehydrogenase and furthermore the degradation by beta-oxidation was delayed. About 13% of the given dose of 15-methyl-delta 4-cis-PGF1 alpha was excreted unchanged into urine and feces from the monkey. The corresponding figure for 16,16-dimethyl-delta 4-cis-PGF1 alpha was about 20%. In addition, a large part of the metabolites had the carbon skeleton intact and were only metabolized by omega-oxidation. The relative resistance to degradation of these two analogues is likely to be the basis for their prolonged pharmacological activity.

Animals↗
PubMed1978

Intramural oesophageal cyst with massive mediastinal bleeding. A case report.

Intramural oesophageal cysts lined by ciliated columnar epithelium are considered to be lesions which are not prone to serious complications except infection. In contrast to this view, a case of intramural oesophageal cyst recently operated upon by us, in which severe mediastinal bleeding developed, is described.

Adult↗
PubMed1978

Occurrence of previous neck radiotherapy among patients with associated non-medullary thyroid carcinoma and parathyroid adenoma or hyperplasia.

Sixteen consecutive patients with co-existent non-medullary thyroid carcinoma and parathyroid adenoma or hyperplasia are reported. Ten of these patients had earlier been treated with external radiation in the neck region. The estimated absorbed dose varied between 5 and 23 gray. The diagnosis of thyroid carcinoma and hyperparathyroidism (HPT) was established 36 years (average) after exposure to radiation. The findings are in accordance with the hypothesis that radiation can serve as an etiological factor in the development of associated thyroid carcinoma and HPT.

Adenocarcinoma↗
PubMed1978

Massive parathyroid hemorrhage in a case of water-clear cell hyperplasia.

A case of water-clear cell hyperplasia of the parathyroid glands is reported. As far as we know this case is unique in respect of the following features. All the parathyroids were located in the superior mediastinum. One abnormal parathyroid gland was removed with the help of a mediastinoscope. The patient survived a massive parathyroid hemorrhage. This case draws attention to the facts that enlarged parathyroid glands can appear as mediastinal tumours and that massive bleeding can occur in abnormal parathyroid glands.

Adenoma↗
PubMed1977

Hyperparathyroidism in persons treated with X-rays for tuberculous cervical adenitis.

Follow-up examinations of one hundred persons treated with x-rays for tuberculous adenitis between 1930 and 1946 have been carried out to determine if there is an increased incidence of hyperparathyroidism (HPT) after radiation exposure. Neck explorations were done in patients with hypercalcemia and signs and symptoms compatible with HPT. Individuals with thyroid masses were also operated upon when examination of fine needle specimens gave suspicions of malignancy. Eleven subjects were found to have developed parathyroid adenoma or hyperplasia. Four other individuals have hypercalcaemia but are asymptomatic. The mean absorbed dose in the parthyroid glands varied between 75 and 2,200 rads. Six individuals received more than 1,200 rads; four of them later developed HPT, while no HPT occurred below a dose of 300 rads. The high incidence of HPT among patients who had been heavily exposed to radiation suggests a cause and effect relationship between radiation treatment and development of HPT.

Adenoma↗