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Biomedical subjects

G Goodman

Publications and source records attributed to G Goodman.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Polyethylene glycol conjugated interleukin-2: clinical and immunologic effects in patients with advanced renal cell carcinoma.

Recombinant interleukin-2 (rIL-2) modified with monomethoxypolyethylene glycol (PEG IL-2) was utilized in patients with metastatic renal cell carcinoma in two separate multi-institutional trials. PEG IL-2 was administered as an I.V. bolus days 1, 8, 15, and 22 with cycles repeated every six weeks. The two trials employed different dose levels: A) 20 x 10(6) I.U./m2 day 1 followed by 12 x 10(6) I.U./m2 days 8, 15, 22; and B) 12 x 10(6) I.U./m2 days 1, 8, 15, 22. Thirty-five patients were entered and 31 were evaluable for response (A-15/18, B-16/17). Two of 31 patients had partial responses. Median therapy duration was four weeks (range 1-15), and dose reduction for grade III or IV toxicity was required in 14/35 patients (A-6/18, B-8/17). Toxicity (> or = grade III) seen included: hypotension 51%, dyspnea 17%, seizures 6%, and mental status changes 11%. No differences in response or toxicity between the two schedules were noted. Hematologic changes included lymphocytosis and eosinophilia in the majority of patients. PEG IL-2 given once weekly has significant toxicity, and may produce tumor regression in patients with renal cell carcinoma.

Adult↗
PubMedDate not supplied

The profession of clinical engineering.

This paper reviews the sociology of professions, examines the background and historical development of professions, and then reviews the present status of the profession of clinical engineering. The historical components of the professionalization process are investigated along with the societal perceptions, the role of education, and the functions of professional societies. The progress of an occupation toward professionalization involves: the appearance of training schools; establishment of university educational programs; licensure or certification; a formal code of ethics; and establishment of one or more national professional associations. A rationale is presented here for the formation of a clearly identified professional society for clinical engineers based on: (1) The need to identify the territory of the clinical engineer by defining the body of knowledge on which clinical engineering is based; (2) The need to structure the educational system of clinical engineering; (3) The need to represent the clinical engineer in the healthcare system; and (4) The need to gain status as a profession.

Biomedical Engineering↗
PubMedDate not supplied

A place in the sun?

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Periodicals as Topic↗
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Incorporating the time dimension in receiver operating characteristic curves: a case study of prostate cancer.

Early diagnosis of disease has potential to reduce morbidity and mortality. Biomarkers may be useful for detecting disease at early stages before it becomes clinically apparent. Prostate-specific antigen (PSA) is one such marker for prostate cancer. This article is concerned with modeling receiver operating characteristic (ROC) curves associated with biomarkers at various times prior to the time at which the disease is detected clinically, by two methods. The first models the biomarkers statistically using mixed-effects regression models, and uses parameter estimates from these models to estimate the time-specific ROC curves. The second directly models the ROC curves as a function of time prior to diagnosis and may be implemented using software packages with binary regression or generalized linear model routines. The approaches are applied to data from 71 prostate cancer cases and 71 controls who participated in a lung cancer prevention trial. Two biomarkers for prostate cancer were considered: total serum PSA and the ratio of free to total PSA. Not surprisingly, both markers performed better as the interval between PSA measurement and clinical diagnosis decreased. Although the two markers performed similarly eight years prior to diagnosis, it appears that total PSA performed better than the ratio measure at times closer to diagnosis. The area under the ROC curve was consistently greater for total PSA than for the ratio four and two years prior to diagnosis and at the time of diagnosis.

Adult↗
PubMedDate not supplied

Non-melanotic skin cancer and solar keratoses in Victoria.

The light-exposed areas of the head and neck, forearms, and dorsum of each hand were examined in 2113 adults during a one-week study. The study was conducted in the isolated Victorian rural city of Maryborough which is situated in the northern part of the Central Highlands district. Of 2113 subjects, 49 (2.32%) had at least one skin cancer and 1202 (56.9%) had at least one solar keratosis. Histological confirmation of all skin cancers and doubtful solar keratoses was obtained. Age, skin type, and sunlight exposure were the major factors influencing the prevalence of solar keratoses and skin cancers.

Adult↗
PubMedDate not supplied

Self-protection.

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Crime↗