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Biomedical subjects

G Gonnella

Publications and source records attributed to G Gonnella.

26 records · Page 2Linked to original sources
PubMed1993

[Treatment of symptomatic bone metastases of prostatic carcinoma using strontium chloride (Sr-89)].

Until now, patients with a progressive prostatic cancer, in whom all therapies failed and the disease spread locally and distally, was considered "a lost patient"; because it did not exist an effective therapy easily to be used. The skeletal pain control is a serious problem and it is a great responsibility also for the Urologists especially if the patient has not a short survival time and the quality of life is very poor. Physicians feel the need for a systemic, well tolerated and effective therapy also for a long time, uniform and repeatable, able to be efficient for these patients. Strontium 89 chloride seems to offer all these possibilities and to be the best procedure for Urologist, Radiotherapists and Nuclear Specialists in order to satisfy the patients requirements. International research has shown Sr-849 Chloride is a powerful new therapy. Sr-89 Chloride is a radiopharmaceutical product for the treatment of painful metastases from prostatic cancer. It is a new treatment but its effectiveness is well documented and results are reported in the most important international literature. In our Department a clinical research has started and our purpose is to produce more data for a clinical and biological evaluation of the results, hoping that a similar research will extend as a multicenter study.

Bone Neoplasms↗
PubMed1992

[Treatment of symptomatic bone metastases of prostatic carcinoma with strontium (Sr-89) chloride: initial experience].

Until now, patients with a progressive prostatic cancer, in whom all therapies failed and the disease spread locally and distally, was considered "a lost patient"; because it did not exist an effective therapy easily to be used. The skeletal pain control is a serious problem and it is a great responsibility also for the Urologists especially if the patient has not a short survival time and the quality of life very poor. Physicians feel the need for a systemic, well tolerated and effective therapy also for a long time, uniform and repeatable, able to be efficient for these patients. Strontium 89 chloride seems to offer all those possibilities and to be the best procedure for Urologist, Radiotherapists and Nuclear Specialists in order to satisfy the patients requirements. International research has shown Sr-89 Chloride is a powerful new therapy. Sr-90 Chloride is a radiopharmaceutical product for the treatment of painful metastases from prostatic cancer. It is a new treatment but its effectiveness is well documented and results are reported in the most important international literature. In our Department a clinical research has started and our purpose is to produce more data for a clinical and biological evaluation of the results hoping that a similar research will extend as a multicenter study.

Bone Neoplasms↗
PubMed1991

[Sedation with flunitrazepam and its antagonism with flumazenil in endoscopic urological procedures: our clinical experience].

Patients, especially males, do not easily stand endoscopic urological diagnostic examinations. So flunitrazepam (0.01 mg/kg IV) has been used to insure a suitable sedation. At the end of such examination flumazenil, a selective benzodiazepine antagonist has been injected. The levels of sedation and orientation so obtained and the cardiorespiratory parameters have been collected during a one hour follow-up from the intravenous injection of the antagonist. This method presents minimal side effects (a marginal, but statistically significative, systolic arterial pressure reduction), a completely normal coordination of movements and awareness of space and time relationship at the end of the observation period. Therefore it is a very good solution for short time examinations giving the chance to safely and shortly dismiss the patient.

Adult↗
PubMed1990

[Complications and limitations of pelvic ureter endoscopy].

We report complications and general limits of low ureteroscopy in relation to the use of ureteroscope in a normal or pathologic urinary tract and during rigid ureteroscopy for diagnostic purpose or instrumental procedures. It is plain that limits are represented by anatomic or pathologic urinary tract alterations whereas complications only depend on instrumental procedures. Complications are less frequent in the pelvic ureter and seem to give few negative results.

Endoscopy↗
PubMed1985

Results of treatment with Bacillus subtilis spores (Enterogermina) after antibiotic therapy in 95 patients with infection calculosis.

We studied the effect of oral Bacillus subtilis spore administration in a group of 95 patients with stones-associated recurrent urinary tract infections. There was a significant reduction in the frequency of infection episodes in the group treated with Bacillus subtilis spores plus antibiotics (treated group) compared with the group treated with antibiotics alone (controls). Urinary pH decreased significantly in the treated group compared with the controls. Patients with stone disease in situ had a worse prognosis. The immunomodulatory and stabilizing effect of Bacillus subtilis spores on the intestinal flora is probably responsible for this improvement.

Anti-Bacterial Agents↗