Search PubMed⌕ Search

Biomedical subjects

G Goldberg

Publications and source records attributed to G Goldberg.

At least 73 records · Page 4Linked to original sources
PubMed1987

Automated three-part leukocyte differential counts in the preoperative evaluation of ambulatory surgery patients.

The clinical value of the Coulter S-Plus V three-part leukocyte differential cell count in the preoperative evaluation of 295 patients scheduled for ambulatory surgery was examined. Ninety-five percent of the specimens could be processed by the instrument without further review. Only 11 specimens had abnormal manual differential cell counts. Of these, all but three were detected using a combination of S-Plus V-generated flags and preset laboratory criteria. There were 16 cases with red blood cell morphologic abnormalities, eight of which were not associated with specimens referred for complete manual differential cell count. In none of these 11 unreferred cases was the undetected abnormality of clinical significance relative to the patient's upcoming surgery. The use of the S-Plus V three-part differential in this patient population can result in a significant cost savings without adversely affecting patient care.

Ambulatory Surgical Procedures↗
PubMed1986

Comparative study of a new ultrastructural specialization of the mammalian retinal pigment epithelium: basal intracytoplasmic tubules.

We recently described basal intracytoplasmic tubules that arise from the basal plasma membrane of rat retinal pigment epithelial cells (RPE). They are a previously undescribed ultrastructural specialization of the basal plasma membrane in addition to the well-known basal folds. This report describes similar tubules in the RPE cells of the rabbit, hamster, and kitten. As in the rat, the tubules in the hamster and kitten ramify singly through the basal cytoplasm and bear no special relationship to any other organelle. In the rabbit, however, stacks of closely apposed tubules frequently abut the large lipid droplets in their RPE cells. Although the function of the tubules is unknown, their occurrence in several different mammals suggests they are involved in the function of RPE cells in general.

Animals↗
PubMed1986

Ovarian Sertoli-Leydig cell tumour with raised serum alpha fetoprotein. A case report.

A case of ovarian Sertoli-Leydig cell tumour with a raised serum alpha fetoprotein is reported. The patient first presented at the age of 27 years with a history of 6 years' amenorrhoea followed by 3 months irregular vaginal bleeding. A ovarian tumour was found and excised and shown microscopically to be a spindle cell malignant tumour. The patient was treated with chemotherapy and had a complete response. Thirty months after first presentation there was a recurrence in the pelvis which microscopically showed the typical features of a Sertoli-Leydig cell tumour. Six months later a second recurrence had the microscopic appearance of a lipid cell tumour. A raised serum alpha fetoprotein was found at the time of the second recurrence and immunohistochemistry showed this protein in the Leydig and luteinized cells of the recurrent tumours but not in the spindle cells of the original ovarian neoplasm.

Adult↗
PubMed1986

The use of concomitant chemotherapy and radiotherapy prior to surgery in advanced stage carcinoma of the vulva.

Six cases of primary advanced squamous carcinoma of the vulva were treated with concomitant chemotherapy and radiotherapy (C + RT). In five patients it was given in preparation for surgery. The radiation was delivered to the whole pelvis in 10 equal daily fractions of either 2.0 or 2.5 Gy. Mitomycin C (10 mg/m2) was given on Day 1, and 5-fluorouracil (1,000 mg/m2) was given daily from Days 1 to 4, inclusive. All six patients had satisfactory early tumor response. Three patients received one course of C + RT and three were given two courses. One patient died suddenly of unknown causes 6 days after completing the C + RT. One patient with fixed groin nodes was treated with palliative intent. She maintained a complete local response but died 6 months later of liver metastases. The remaining four patients underwent surgery without healing complications and are alive with no evidence of disease at 1, 4, 14, and 26 months. In our experience vulval carcinomas can be reduced in size and extent by prior chemotherapy and radiotherapy and require less extensive surgery.

Adult↗
PubMed1986

Human fibroblast collagenase: glycosylation and tissue-specific levels of enzyme synthesis.

Human skin fibroblasts secrete collagenase as two proenzyme forms (57 and 52 kDa). The minor (57-kDa) proenzyme form is the result of a partial posttranslational modification of the major (52-kDa) proenzyme through the addition of N-linked complex oligosaccharides. Human endothelial cells as well as fibroblasts from human colon, cornea, gingiva, and lung also secrete collagenase in two forms indistinguishable from those of the skin fibroblast enzyme. In vitro tissue culture studies have shown that the level of constitutive synthesis of this fibroblast-type interstitial collagenase is tissue specific, varies widely, and correlates with the steady-state level of a single collagenase-specific mRNA of 2.5 kilobases. The tumor promoter, phorbol 12-myristate 13-acetate, apparently blocks the control of collagenase synthesis resulting in a similarly high level of collagenase expression (approximately equal to 3-7 micrograms of collagenase per 10(6) cells per 24 hr) in all examined cells. The constitutive level of synthesis of a 28-kDa collagenase inhibitor does not correlate with that of the enzyme. Phorbol 12-myristate 13-acetate stimulates the production of this inhibitor that in turn modulates the activity of collagenase in the conditioned media. As a result, the apparent activity of the enzyme present in the medium does not accurately reflect the rate of its synthesis and secretion.

Endothelium↗
PubMed1986

Dental insurance and the oral health of preschool children.

Using data from the Rand Health Insurance Experiment, the effects of cost-sharing plans on the health of the primary teeth in 264 children aged 3 to 5 years were investigated. From six areas in the United States, families were assigned at random to different dental and medical insurance plans. The plans varied in the amount of required cost sharing. Families participated in the study for 3 (70%) or 5 (30%) years. Children covered by the plan (requiring no cost sharing) had significantly fewer decayed teeth and deft (decayed, extracted, and filled teeth) at the end of the study than did children covered by the cost-sharing plans. No differences existed among plans in the number of extracted and restored teeth. Children of middle- and low-income families benefited most from having access to free dental care.

Child Health Services↗
PubMed1986

Quality of care for psychotropic drug use in internal medicine group practices.

To evaluate the care given by internists in group practices at 16 academic medical centers to patients who used minor tranquilizers or antidepressants, data were abstracted from medical records and compared with specific criteria for quality care.Of 1,532 continuing care patients, 18% used minor tranquilizers and 7% used antidepressants. Almost 90% of antidepressants were prescribed for depression and 50% of minor tranquilizers were prescribed for mental health problems. The group practice internists performed well on concrete aspects of care, such as avoiding giving minor tranquilizers intravenously or intramuscularly and scheduling follow-up visits. Relatively few patients, however, had an adequate treatment plan noted in the chart. About 25% of users of minor tranquilizers did not have an acceptable indication for the drug noted in the chart. Less than 10% of users of minor tranquilizers had a plan for discontinuing the drug use; yet, 35% had long-term regular use.

Group Practice↗
PubMed1985

Renal infarction.

A 43-year-old woman complaining of left flank pain was found to have renal infarction. New-onset atrial fibrillation suggested thromboembolism, which was confirmed by retrograde urogram and intravenous pyelogram. The patient was treated with heparin and was discharged on coumadin after evaluation of her cardiac disease.

Adult↗
PubMed1985

[Compound Hurler-Scheie disease in 3 siblings].

The present paper describes 3 out of a total of 9 siblings, aged 9, 17, and 18, with the following symptoms: gargoyle-like facial features, clouding of the cornea in both eyes, dysostosis multiplex, slightly impaired intelligence, hepatosplenomegaly, umbilical hernia, and increased secretion of mucopolysaccharides in the urine, in particular dermatan and heparan sulfate. Some of the symptoms are mid-way between those of Hurler's and Scheie's syndromes, both having the same deficiency of the enzyme alpha-1-iduronidase. McKusik developed the theory that the genes responsible for the clinical pictures of Hurler's and Scheie's syndromes are alleles and hence cases such as those described here should be considered as allelomorphic compounds.

Adolescent↗
PubMed1985

General medical care and the education of internists in university hospitals. An evaluation of the teaching hospital general medicine group practice program.

Fifteen general internal medicine group practices in university teaching hospitals were studied to evaluate their primary care services and education. Data were collected over 9 months from physicians, patients, and medical records, and by observation. All institutions had closed their general medical clinics. Many patients being treated in group practices were very sick; 57% had hypertension; 21% were diabetic; and 45% could not work. Most were satisfied with their care. Care for acute problems from a health care provider in the practice was available quickly; regular physicians were harder to see. House staff and faculty spent little time in the practices. Few practices used teams; most used traditional attending and house staff models. Practice physicians could not easily determine when patients were seen in the institution's emergency department or were hospitalized. Quality of care standards were not uniformly met. Finally, the structure of academic centers appeared to inhibit the practices' performance, suggesting a need for further appraisal of relationships between university hospitals and their ambulatory care units.

Appointments and Schedules↗
PubMed1985

Role of cul-de-sac aspiration cytology in the management and follow-up of patients with ovarian carcinoma. A preliminary report.

In a pilot study involving 44 patients on combined chemotherapy for epithelial ovarian carcinoma, cul-de-sac aspiration cytology was compared with second-look surgery in the evaluation of disease status. There was a 92% correlation. Our preliminary conclusion was that an aspirate from the cul-de-sac or peritoneal cavity can be obtained with ease and that if this finding is confirmed in a larger series now in progress, the procedure may in part replace second-look operations in the management of these patients.

Adenocarcinoma↗