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Biomedical subjects

G Gentile

Publications and source records attributed to G Gentile.

At least 73 records · Page 4Linked to original sources
PubMed1993

Cervical intraepithelial neoplasia in HIV seropositive patients.

In order to assess the frequency of cervical intraepithelial neoplasia (CIN) in a high risk population, 32 women infected with human immunodeficiency virus (HIV), with no AIDS-related symptoms, underwent colposcopic, cytologic and histologic examinations of the uterine cervix. In seven cases (21.9%) cervical smears showed dysplasia and in nine cases (28.1%) histologic evaluation indicated CIN. No invasive carcinomas were observed. In seven of the nine women CIN was associated with lesions due to human papillomavirus infection (HPV). These data confirm that HIV-positive women are at increased risk for developing neoplasias in the lower genital tract and are in need of regular and careful cytologic and, in particular, colposcopic and histologic examinations.

Adult↗
PubMed1992

[Extraskeletal myxoid chondrosarcoma of the abdominal wall. A clinical, histological, ultrastructural and cytofluorimetric case study].

The authors present a case of extraskeletal myxoid chondrosarcoma of the abdominal wall, an unusual localization and specific presentation. According to the literature, the clinical characters of this kind of tumor, the diagnostic iter and the therapeutic indications are being examined. The actual anatomopathological patterns used for the diagnosis of this neoplasm are being underlined.

Abdominal Muscles↗
PubMed1992

Piperacillin plus amikacin vs. piperacillin plus amikacin plus teicoplanin for empirical treatment of febrile episodes in neutropenic patients receiving quinolone prophylaxis.

A prospective, randomized trial was initiated to evaluate the efficacy of two antibiotic regimens, differing in the agent included with activity against gram-positive bacteria, for the empirical treatment of febrile episodes in neutropenic patients with hematologic malignancies (group 1, piperacillin plus amikacin; group 2, piperacillin plus amikacin plus teicoplanin). After 72 hours of therapy, patients in group 1 who were still febrile were administered teicoplanin and those in group 2 were administered amphotericin B. A total of 158 evaluable episodes were observed within 8 months. The success rate was 50.6% in group 1 and 60% in group 2. The response rate among patients who did not respond to the original regimen increased to 86.7% with the addition of teicoplanin (group 1) and to 90% with the addition of amphotericin B (group 2). There were 86 unexplained febrile episodes and 56 documented episodes of bacteremia (34 caused by gram-positive organisms). Our results indicate that teicoplanin is safe, well tolerated, and effective for the treatment of documented episodes of gram-positive bacteremia and as an empirical agent. The inclusion of teicoplanin in the initial empirical regimen appears unnecessary if a combination of antibiotics active against gram-positive organisms is used, unless infections are due to oxacillin-resistant staphylococci.

4-Quinolones↗
PubMed1992

Single daily dose ceftriaxone plus amikacin treatment of febrile episodes in neutropenic patients attending day hospital for hematologic malignancies.

Once-a-day ceftriaxone and amikacin was administered in case of fever to 46 neutropenic patients attending day hospital for hematologic malignancies. All patients were admitted to a short-term ward for infective complications, but were discharged in the event of prompt disappearance of fever and of clinical signs of infection continuing their therapy either by daily reporting to the hospital, or at home. Response to the initial empiric therapy was obtained in 37 cases (76%). Twenty-four patients who promptly responded to therapy completed their treatment on an outpatient basis, their mean number of days of hospitalization being reduced to 4.6 versus a mean of 9.6 days in the overall patient population being considered. Since the outpatient treatment accounted for 21% of the antibiotic therapy administered, the above treatment may result in cost containment and better quality of life for patients, provided that these data are confirmed by prospective randomized studies.

Adolescent↗
PubMed1992

[Polycystic retroperitoneal leiomyosarcoma. A clinical and anatomo-pathological contribution].

The Authors report an unusual case of retroperitoneal leiomyosarcoma, multicystic, resembling an ovarian cystoma in a patient with simultaneous subclavian-axillary thrombosis. They analyze anatomo-pathological and clinical aspects of this kind of tumor and underline the possible errors they themselves faced. To they come to the conclusion that a careful diagnostic iter of this kind of tumor must be carried out and that the surgical approach must be radical.

Aged↗
PubMed1992

[Viral infections in children with kidney or heart transplants].

The introduction of new protocols of immune suppression and especially the use of cyclosporine have led to a marked reduction of infective pathology in children receiving transplants. Nevertheless, infections still represent a major factor of morbidity and mortality in these patients. The above study lists the main viral infections, according to apparatus involved, that may arise, also with reference to the time elapsed since transplantation. The most up-to-date diagnostic possibilities for each infection are reviewed together with some indications on therapy which may subsequently be examined in greater detail.

Acyclovir↗
PubMed1992

Ki-67 antigen expression in lymphocytes of cattle infected with bovine leukemia virus (BLV).

The Ki-67 monoclonal antibody, which recognizes an antigen present on the nuclear membrane surface of mammalian cells in the replication phase, has been used for the determination of the cellular cycle of peripheral blood lymphocytes on a group of cattle positive for bovine leukemia virus (BLV) and with blood values showing a persistent lymphocytosis. The results obtained have shown that: 1. Both of the techniques used (immunofluorescence and immunoperoxidase) are easily applicable and give uniform results; 2. Cattle with a persistent lymphocytosis show an absolute number of cells in cycle significantly more elevated compared with cattle positive for BLV with normal blood values.

Animals↗
PubMed1991

[A mucinous cystadenocarcinoma of the pancreas. A clinical and histopathological contribution].

Two cases of pancreatic cystadenocarcinoma, a very rare pathology, are reported. The authors treat the anatomopathological classification and they underline the diagnosis especially with reference to the new methods of cytologic study. Finally they consider the surgical approach that must be radical because of the potential malignancy of this kind of tumor whose prognosis is quite good with a lasting long-term survival.

Adult↗
PubMed1991

Species identification and detection of oxacillin resistance in coagulase-negative Staphylococcus blood isolates from neutropenic patients.

One hundred coagulase-negative staphylococcal isolates from septicemic neutropenic patients with hematologic malignancies were identified to a species level by means of the French API STAPH strip system and by the Automicrobic VITEK system. According to these two methods, which concurred in 95% of cases, S. epidermidis (80-82% of the isolates) was the most frequently identified species, followed by S. haemolyticus (6-7% of the isolates). The susceptibility to oxacillin was also evaluated by macrodilution MIC, Automicrobic VITEK system and agar screen, and 76, 78 and 79 of the 100 isolates, respectively, were found resistant to this antibiotic. All oxacillin-resistant isolates according to Automicrobic VITEK were confirmed resistant by agar screen. A 48h incubation was required to determine oxacillin resistance in 11 of 79 isolates with agar screen and in 10 of 76 isolates with macrodilution MIC. Automicrobic VITEK system may represent a useful method for rapid identification to a species level and early recognition of oxacillin resistance in coagulase-negative staphylococci.

Bacteremia↗
PubMed1991

Immunosuppression and human genital papillomavirus infection.

A group of 39 patients who underwent iatrogenic immunosuppression for renal transplant were evaluated by means of colposcopic, cytologic, and histologic investigations. Evidence of human papillomavirus (HPV) infection was found in 30.7%, more frequently in the cervix. Biopsy specimens of the most atypical areas showed the presence of cervical intra-epithelial neoplasia in one case. The high incidence of HPV infection in this group suggests that immunodeficient patients should have close monitoring of the entire ano-genital tract.

Adult↗
PubMed1991

Evolution of the indications for cesarean section. Results of a retrospective study.

We have analysed in retrospect the incidence of cesarean section during the years 1977-1989 in the 1st Obstetric and Gynecologic Clinic of the University of Bologna, and the development over time of the principal indications. The average incidence (17.1%) of cesarean section increased progressively from 9% in 1977 to 28% in 1989 with a peak at the beginning of the '80s (the period during which cardiotocographic monitoring became routinely used). With regard to the indications from 1977 up to date cesarean sections carried out on account of fetal distress increased almost five-fold. The increase in cesarean sections carried out on account of maternal disease, breech presentation and previous cesarean section was less important, while those performed for dystocia resulted markedly reduced.

Adult↗
PubMed1990

[Aneurysm of the left gastric artery. Clinical contribution and review of the literature].

The extra-visceral aneurysms of the gastric arteries are very rare and their diagnosis occurs mostly in the presence of haemoperitoneum and shock due to their rupture. Through echography and selective arteriography a right diagnosis can be made before a rupture. The treatment is surgical with good results but treatment with embolisation through arteriography is preconized. Two cases treated in emergency are reported.

Aged↗
PubMed1990

A modelistic approach to evaluate the factors affecting the 137Cs transfer from mother to fetus in cattle.

The authors have analysed the relationship between 137Cs radioactivity and pregnancy in cattle with radiometric analysis of muscle, kidney and liver of 24 cattle at various stages of pregnancy, fed with fodder exposed to radioactive fall-out. Also the relative fetal muscle, kidney, liver and myocardium have been analysed. The automatic spectra analysis and the statistical one have given the following results: there is no correlation between 137Cs retention and the pregnancy stage in the cattle sampled; the absolute 137Cs concentration is always larger in the kidney than in the muscle (Km/Mm = 1.7), while it is just minor in minor in the liver (Lm/Mm = 0.8). The fetal concentration in muscle, kidney and liver is generally homogeneous, whereas the myocardium tends to retain more 137Cs in the first stages of the pregnancy as against the other tissues. In the last stage of pregnancy it presents a lower concentration. The authors have included the fetal body weight growth to get a more realistic description of the 137Cs transfer in the mother-fetus system; this approach enables to evaluate the kinetic constants so introduced.

Animals↗
PubMed1989

Cryptosporidium as a common cause of childhood diarrhoea in Italy.

Cryptosporidium oocysts were observed in the stools of 9 (7.2%) of 124 Italian children with diarrhoea, examined during the period 1 January-31 December 1984. In two children, the parasite was associated with other enteric pathogens. The duration of diarrhoea was 2-30 days, with a median of 6 days. In all cases the infection was self limiting. The mean age of the Cryptosporidium-positive children was 34 months, and all cases occurred in the warm season. Cryptosporidium was found to be the third most common enteric pathogen after rotavirus and Salmonella spp.

Animals↗