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Biomedical subjects

G Gardos

Publications and source records attributed to G Gardos.

67 records · Page 4Linked to original sources
PubMedDate not supplied

An evaluation of papaverine in tardive dyskinesia.

An evaluation of papaverine was carried out in nine hospitalized chronic patients with moderate to servere tardive dyskinesia. Changes in movements were assessed on the Simpson and AIMS scales by two trained rates blind to the study design. Results showed a modest 20-25 per cent improvement in oral dyskinesia, but only two of the nine patients showed clinically obvious improvements in their movement disorders. No drug-induced side effects were found. The mechanism of pharmacologic action of papaverine in movement disorders needs to be clarified, but dopamine receptor blockade may be primarily involved.

Adult↗
PubMedDate not supplied

The evaluation and treatment of neuroleptic-induced movement disorders.

Tardive dyskinesia, tardive akathisia, and tardive dystonia are reviewed from a clinical perspective. The evaluation of each syndrome is discussed, and its clinical presentation and course are illustrated with case vignettes. Drugs used in the treatment of tardive dyskinesia are presented, with greater emphasis on the more recently introduced therapies such as clozapine and vitamin E. Although effective treatments remain elusive, neuroleptic-induced movement disorders can be managed satisfactorily in the majority of clinical situations. Algorithms are presented to outline treatment approaches for mild and moderate/severe tardive dyskinesia.

Adult↗