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Biomedical subjects

G Galvan

Publications and source records attributed to G Galvan.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Factitious hyperthyroidism caused by L-thyroxin abuse. Case report].

A 43 years old female was treated for 8 months with antithyroid drugs because of a difficult adjustable hyperthyroidism. In spite of this massive antithyroid therapy a threatening deterioration of the clinical picture occurred. The reason for it was the secret intermittent intake of up to 1200 micrograms lT4 daily motivated by private problems. The difficulties of a differential diagnosis between a thyrotoxicosis factitia and an endogenous hyperthyroidism is stressed. One should always consider a thyrotoxicosis factitia in the case of suggestion of a psychopathia and when thyroid hormone medication is used for suppressive thyroid hormone therapy or as a prophylaxis of goiter recurrence. In addition overweight, major personality disorders and resistance to antithyroid drugs are indicative for thyroid hormone abuse. Important indicators for the differentiation between a thyroid hormone abuse and an endogenous hyperthyroidism are a lack of technetium- or radioiodine-uptake in the thyroid and suppressed levels of thyroglobulin.

Female↗
PubMed1982

[Iodine deficiency in Salzburg in spite of iodized table salt prophylaxis].

Urinary iodine excretion was determined in 293 medical technical and nursing students in hospitals of the province Salzburg. The average urinary iodine excretion amounted to 46.6 +/- 18 micrograms iodine per gram creatinine. 67.6% of the students showed a deficiency of iodine II, whilst 98.3% had a deficiency of iodine I according to WHO criteria. Urinary iodine levels and natriuria are closely correlated, indicating that iodized table salt probably constitutes the most important source of iodine. 73 of the students had a palpable giotre, 10 of these being nodular. Our investigations, together with those of Innsbruck, Graz and Vienna, demonstrate the existence of generalized iodine deficiency in spite of iodized salt prophylaxis, which has been legally enforced in all of Austria since 1963. Iodized table salt prophylaxis has, thus, led to a drastic decrease in goitres in children, but is not sufficient to eliminate iodine deficiency in adults. An increased level of iodization of table salt, as has been put into force in Switzerland, must be called for in Austria, too.

Adolescent↗
PubMed1982

[Therapy of thyroid cysts with fine needle aspiration].

In a study extending over a period of 4 years, therapeutic fine-needle aspirations were carried out in 194 thyroid patients with thyroid cysts. The cyst contents of 3-130 ml cyst fluid were completely removed by suction in 2-3 month intervals by 1-17 fine-needle aspirations on an outpatient basis. Malignancy was ruled out in all patients by repeated cytological tests. Complete emptying of the cyst, verified by twice-repeated check at 3-month intervals, was achieved in 86 patients (44.3%). A reduction of the cyst fluid to less than 30% was achieved in 13 patients (6.7%). In 17 patients (8.8%) the cyst fluid diminished to 31-50%. In 44 patients (22.7%) there was no diminution in the cyst fluid or a reduction of less than 50%. There was an increase in cyst fluid compared with the first puncture in 34 patients (17.5%). The success of puncture cannot be predicted, although cysts with brown cyst fluids can be emptied significantly more frequently than cysts with yellow cyst fluids (63% as compared with 43.5%, p less than 0.005). Cyst fluid volume, T3- and T4-contents of the cyst fluid, age and sex had no influence on therapeutic effect. Up to the 5th puncture the prospects of success are approximately constant, but even in cases of more frequent punctures emptying still takes place. Thyroid hormone therapy with 50-100 micrograms 1-T4 daily (n = 134), and a single intracystic injection of 40 mg methylprednisolone-crystal suspension (n = 42) or of 0.02 g hydroxypolyaethoxydodecan 1% (n = 11) did not show better results than the single aspiration. There were no complications except for 2 cases of afterbleeding in the cysts immediately after puncture, and these were easily dealt with. Fine-needle aspiration is a simple, effective and cost-saving method for the elimination of the frequent cosmetically disturbing thyroid cysts in half of patients, thus avoiding surgery.

Cysts↗
PubMed1981

[Bromocriptine induced cystic tumour regression in advanced prolactinomas (author's transl)].

Conservative treatment with bromocriptine was performed in three patients with macroprolactinomas and increased prolactin levels. Lowering of prolactin levels to normal or subnormal values was possible in all cases. One extensive prolactinoma with retro- and suprasellar parts showed regression to a large extent and cystic degeneration. Transient occurrence of liquorrhoea is considered as a consequence of tumour regression. In cases of parasellar prolactinoma recurrence and intrasellar prolactinoma diminution and cystic degeneration were observed while on bromocriptine treatment. Bromocriptine dosage varied between 3.75 and 30 mg/d. Treatment was performed between 20 and 26 months. There were no serious side effects. Bromocriptine treatment offers an alternative to surgery in macroprolactinomas and prolactinoma recurrences.

Adult↗
PubMed1981

The influence of fibrin stabilization and fibrinolysis on the fibrin-adhesive system. A clinical study using radioactively marked fibrinogen as a tracer.

In many fields of surgery the use of highly concentrated human fibrinogen, which forms a fibrin clot when thrombin is added, is gaining increasing importance for tissue adhesion. A number of experimental and clinical reports on fibrin sealing have been published during recent years. The question underlying our present investigations is as follows: What happens to the tissue adhesive after its application to a wound in clinical use, i.e., how much time is required for complete resorption of the seal due to fibrinolytic processes? Skin graftings of the face (required to close defects caused by the excision of basal or spinal cell carcinomas) were performed by glueing rhomboid flaps or full thickness skin grafts to the wounds with the tissue adhesive to which 125I-marked fibrinogen has been added. Activity counts were recorded daily and CPM were plotted versus time to obtain summation curves. The physiological processes of fibrin stabilization and fibrinolysis are extensively discussed as both factors influence the tissue adhesive and thus have to be accounted for in clinical practice.

Aged↗
PubMed1980

The effect of chronic administration of a synthetic LH-RH analogue intranasally in cryptorchid boys.

Eighteen boys with either unilateral or bilateral cryptorchidism were treated with a synthetic LH-RH analogue ("D-Leu 6, Des-Gly-10 LH-RH ethylamide") intranasally. The peptide was dissolved in aqueous solution (25 micrograms in 0,2 ml) and administered in the form of nasal drops. The patients were divided in two groups: in group A, 50 micrograms of the synthetic LH-RH analogue were administered intranasally every 48 h for 36 days; in group B same dose was given every 24 h. Additionally, in 4 cases a LH-RH test prior the trial was performed with the same peptide. The nasal administration resulted in a fivefold increase of LH and of FSH plasma concentration in 30 min and in 60 min, respectively. The endocrine profiles for T, LH and FSH were studied in each group over the treatment period and in group B (same dose was given every 24 h) a significant decrease of the LH and FSH plasma levels could be found. The clinical effect of treatment was same in the both groups. In the whole material 44% had either unilateral or bilateral descent of the testis after the therapy.

Administration, Intranasal↗
PubMed1978

[Triiodothyronine, reverse-triiodothyronine, thyroxine, resin-triiodothyronine-uptake and protein bound jodide in the fluid of thyroid cysts (author's transl)].

T3, rT3, T4, PBI and the saturation of T3-T4-binding proteins in yellow and brown cyst fluids of nontoxic goiters differ from the values in sera. In the brown cyst fluids, resulting from a hemorrhage, T3, rT3, T4, PBI and T3 U are significantly higher than in sera and no correlation could be found with the values in sera. In the yellow cyst fluids T3 and T3 U are significantly higher then in sera, T4 is lower, PBI and rT3 do not differ from the values in sera. Only T3 and rT3 are not correlated. Various reasons for higher concentrations of hormones in the cyst fluid such as destruction of thyroid follicles and lymphvessels, a high protein concentration and direct secretion of hormones and iodoproteins from thyroid tissue in the cyst wall into the cyst fluid are taken into consideration. As these hormones in the cyst fluid may be absorbed, the results are also of clinical value.

Blood Proteins↗
PubMed1978

[Hypothalamic peptide hormones].

After a review of the significance of the releasing and inhibiting polypeptide hormones of the hypothalamus, the clinical significance of the gonadotropin-releasing-hormone and the thyrotropin releasing hormone, is discussed in detail.

Amino Acid Sequence↗
PubMed1977

[Concordant medullary thyroid carcinoma in identical twins with discordant phaeochromocytoma (Sipple syndrome) (author's transl)].

The first case of Sipple syndrome in identical twins is reported. It is concluded that the concordant medullary carcinoma of the thyroid is the result of a germinal mutation, whilst the discordant solitary phaeochromocytoma is caused by a somatic mutation according to the two mutation model. The practical conclusion to be drawn from this report is that if one identical twin develops carcinoma of the thyroid or a phaeochromocytoma, the other twin should be throughly investigated and surgical exploration undertaken, even in the absence of clinical evidence of disease.

Adult↗